Grabowicz lab
@GrabowiczLab
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Bacterial genetics lab interested in antibiotic resistance @EmoryUniversity 🇦🇺🇺🇸
Atlanta, GA
Joined October 2018
Congratulations to Dr @J_Marotta for awesome an PhD defense today!! @EmoryMMG @EmoryMicrobio @EmoryARC
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I'm happy to announce that our work on the Lol system of Bacteroidota and its implication in gliding and Type IX secretion is finally online!
nature.com
Communications Biology - Bacteroidota harbor multiple Localization of lipoproteins (Lol) systems, of which one is necessary for the correct localization of gliding motility and Type 9 secretion...
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Unlike Boeings, LolCDE is built tough. Took a lot to break this lipoprotein transporter! See the latest from the lab in @mbiojournal
journals.asm.org
Resistance to current antibiotics is increasingly common. New antibiotics that target essential processes are needed to expand clinical options. For Gram-negative bacteria, their cell surface—the...
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Congratulations to Dr Hannah Smith from @GrabowiczLab who was awarded her PhD today!!! Awesome!!!
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A post doc position in the Zafar lab is available. We focus on Klebsiella pneumoniae gut colonization, specifically looking at how it overcomes colonization resistance. Lots of new & exciting projects. Email mzafar@wakehealth.edu with cv and list of referees. Please retweet!
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An interdisciplinary team of remarkable scientists (and great friends) put together a study leveraging AI to find new antibacterial molecules against Acinetobacter baumannii. I think we are well into an era of AI-augmented drug discovery...WOOO!!! https://t.co/Igp8bRRAv0
nature.com
Nature Chemical Biology - Using a neural network trained on bacterial growth inhibition data, in silico prediction of molecules with activity against Acinetobacter baumannii led to the...
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The Mashruwala group @ScienceStowers will delve into the social behaviors and the development of bacterial communities. Sound interesting? Come join us and explore the fascinating world of bacteria! #science #research #bacteria #microbiology
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When "normal" (rod-shaped) bacteria lose control of cell division, their length changes. How can we find "cell shape" mutants in Staph, which is round pretty much no matter what? Does this different shape need different envelope factors? Come find out! https://t.co/rUWiPlT52e
biorxiv.org
Staphylococcus aureus is a gram-positive pathogen responsible for life-threatening infections that are difficult to treat due to antibiotic resistance. The identification of new vulnerabilities in...
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I'm recruiting a Staff Scientist to contribute to our research on the bacterial outer membrane. If interested, please see the ad at
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My lab is hiring! We are looking for a full time lab tech for 1-2 years who is interested in getting more scientific research experience. Please reach out if you have any questions, and please forward to anyone you think may be interested!
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I’m very excited to share my first graduate school paper that was recently published in @wileymicrobio Thank you to the entire @GrabowiczLab for their support!
Our first #AlphaFold wow moment! Lipoproteins like NlpE detect cell envelope stress, but how? @J_Marotta decided to find out, discovering a key loop in NlpE. Mutants can’t activate the CpxA sensor kinase to signal stress. https://t.co/WJw8aqqMhS
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NlpE is an amazingly adaptable sensor of all sorts of stress. See new stories from @JFClab & @EzratyB: https://t.co/WjjPqf99Gj & from @traivio & @TimCho17:
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She also asked #AlphaFold how NlpE:CpxA might interact… via her NlpE loop! Mutating the predicted interacting residues in CpxA blinds the sensor to NlpE (though not other stressors)! Eerily accurate prediction that matches the genetics!
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Our first #AlphaFold wow moment! Lipoproteins like NlpE detect cell envelope stress, but how? @J_Marotta decided to find out, discovering a key loop in NlpE. Mutants can’t activate the CpxA sensor kinase to signal stress. https://t.co/WJw8aqqMhS
onlinelibrary.wiley.com
We reveal the molecular details of how the sensor lipoprotein NlpE activates the Cpx two-component stress response. Through complementary genetics, biochemistry, and AlphaFold2 modeling, we identif...
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Elegant solution for a big problem. Very nice work
OUT NOW @Nature 👀Coordination of bacterial cell wall and outer membrane biosynthesis https://t.co/XJxBqyZaS5
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New! Gram- cells need lipoproteins to build their surface. LolA & LolB deliver these in E.coli. But many species only have LolA - where's LolB? For Caulobacter, LolB is... LolA! It's a bifunctional protein! We can even tweak E.coli LolA to do double duty!
pnas.org
The outer membrane (OM) is the defining feature of gram-negative bacteria and is an essential organelle. Accordingly, OM assembly pathways and thei...
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WE ARE HIRING--postdoc positions available. Please retweet. Athens is a fun and easy place to live!
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The Emory University M&I Department is accepting applications for a tenure eligible position at the rank of Assistant or Associate Professor within the broad fields of antimicrobial resistance and bacterial pathogenesis. #EmoryMicroBio
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Huge congrats to Dr Kelly Lehman! First PhD student from the Grabowicz Lab 🎉🎉🎉
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