Job Alert! Administrative Manager for new Center for Brain Research in Development, Genetics, and Engineering (BRIDGE Center) at the Children's Hospital of Philadelphia to provide admin leadership and support Center operations. Apply here:

Job Alert! Technical Director to lead the Behavioral Evaluation of Advanced Model Systems (BEAMS) Hub of the BRIDGE Center at Children's Hosp of Philadelphia. Great for a senior postdoc or research associate w/ expertise in behavior

RT @attila_losonczy: Please consider applying for the 2025 Gordon Conference on Inhibition and the preceding Gordon Research Seminar on In….

Rare variants in epilepsy- and autism-linked gene SCN2A are associated with malformation of cortical development, supporting role of NaV1.2 in early brain development: Fun collaboration w/ @nupharm1 @NicolaSpecchio_ @r_guerrini Supported by @NIH_NINDS.

New collaboration with @davidrliu to pursue base editing in a Dravet syndrome model. Thanks to @curedravet for your leadership and vision and continued support of our work to improve the lives of patients with Dravet Syndrome.

Rising star @ZPRosenthal PGY-3 Resident @PennPsych uses a novel mouse model of electroconvulsive therapy (ECT) and DCS/FD-DOS in humans to show that: ECT generates a hidden wave - CSD - after seizure

From postdoc Sophie Hill in a fun collaboration w/ EAP expert @TheyelLab supported by @curedravet : Attenuated Ectopic Action Potential firing in PV interneurons in a mouse model of Dravet Syndrome The function of EAPs remains under investigation.

Postdoc Eric Wengert (brain slice physiologist + educator extraordinaire) teams up with @PennNGG MDPhD student @sophie_liebs and three @Penn undergrads: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy:

We are recruiting to two (2) Tenure-Track Assistant Professor positions in the new BRIDGE Center (Brain Research In Development, Genetics, & Engineering) at The Children's Hospital of Philadelphia/University of Pennsylvania. Details here:

RT @ASalovin: Excited for Neuroscience 2024: Mechanisms and Emerging Therapies for Brain Disorders of Childhood. All @CHOPResearch and Penn….

Superstar @PennNGG student @sophie_liebs throws the kitchen sink at Layer 1 Ndnf cells to show unique preservation of Ndnf interneuron excitability among the major neocortical GABAergic interneuron subtypes in a mouse model of Dravet syndrome.

From postdoc Jade Feng: Kv3 modulator targets cell dysfunction in vitro + motor impairment/seizure susceptibility in vivo in mouse model of Progressive Myoclonus Epilepsy Type 7 (EPM7) This preclinical data supported ID NCT05873062.

Another fun collaboration w/ @ChrisCurrin & @TPVogels plus @DelemotteLab and Manuel Covarrubias:.Jerome Clatot et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction | PNAS

Our new paper studying SCN3A Epilepsy in an IPSC system by postdoc Guojie Qu, @PennNGG superstar Julie Merchant, and sodium channel maestro Jerome Clatot is in @Brain1848 at Great collaboration w/ the lab of Stewart Anderson @CHOP_Research

Postdoctoral Fellowship for Academic Diversity at The Children's Hospital of Philadelphia:.- $65K salary in Yr 1, increasing in $2K yearly increments.- Annual travel ($2K) allowance and supplies ($4K).- Relocation bonus ($5K).- Supervised research training.

When will I stop having to write things like <i>I</i>_NaP in the Figure Legend dialog box when I am uploading manuscripts for review? <b>This wastes <i>a lot</i> of time!</b> The Figure Legends are already included in the Main Text, where they are formatted correctly.

Thanks to @NINDSfunding for support of this preclinical work leading to a candidate therapy for EPM7. This collaboration was led by postdoc Jade Feng with @AutifonyLtd Manuel Covarrubias @Akizulab. We will continue to work to improve the lives of patients with rare disease.

New paper from UPenn MDPhD students past (Kevin Goff), present (@sophie_liebs) and future (Evan Jiang): .VIP-INs are dysfunctional in Dravet syndrome (Scn1a+/-) mice in vivo; deletion of Scn1a in VIP-INs dissociates autism-linked behavior from epilepsy.

RT @LabRubinstein: 📢 A novel gene therapy for #Dravet. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN….

RT @CHOP_Research: Today we’re celebrating the groundbreaking of the latest addition to @ChildrensPhila’s research campus, the Schuylkill A….