Check out the final and peer reviewed version of this preprint published by @CellReports. Congratulations @brianjwoo_bio and thanks to @felixfengmd and @LukeGilbertSF for the support.

Took us a minute, but I am happy to share the final version of this study, now published at @NatureCancer, on behalf of Bruce and Kristle. We have it all, regulatory RNA interactions, oxidative stress/ferroptosis, and metastasis:

Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between @genophoria, @AndreiGoga_SF and @FKHM labs! Shout out to co-authors @Gentremet, @JulianeScience, @lisacfishsci among others!

⭐️ONLINE NOW @NatureCancer “Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes” by @genophoria @SohailTavazoie & Co. 👇 https://t.co/koRUdEVH0H https://t.co/VfMajxe614

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

Very excited to share our paper, identifying a tumor-suppressive tRNA synthetase, published today in @naturecellbiol! https://t.co/6tR9WyZNlA @sohailtavazoie @genophoria @triimdphd @rockefelleruniv… 1/11

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Check out the amazing tools developed by @Gentremet for this study here:

Finally, modulating the poly(A) site selection using a small molecule drug reduces the metastatic lung colonization, providing evidence for a therapeutic vulnerability of HNRNPC-low tumors.

Lower expression of the HNRNPC-PABPC4 axis components increases metastasis in xenograft mouse models and is associated with poor clinical outcomes in breast cancer patients.

In highly metastatic cells, the lower expression of HNRNPC and PABPC4 results in the 3' UTR lengthening of their target mRNAs and subsequent translational repression, at least partly through an Argonaute-dependent RNAi.

HNRNPC is known as a nuclear regulator of alternative splicing – how could it regulate translation? It turns out HNRNPC interacts with PABPC4, a poorly characterized poly(A) binding protein, and binds target mRNAs near poly(A) signals.

This study started with a question: what are the unknowns of translational control in breast cancer metastasis? By combining Ribo-seq and Ribolog, a new tool by @Gentremet for Ribo-seq analysis, we found HNRNPC to control translation of a metastasis suppressing mRNA regulon.

Excited to share the latest results from the @genophoria lab & a great collaboration with @AndreiGoga_SF and @FKHM labs! Shout out to the amazing co-authors @Gentremet, @JulianeScience, @lisacfishsci and many more!