Genetic Engineering & Biotechnology News
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Serving the biotech industry since 1981. EIC @johnsterling4; publisher @liebertpub Subscribe to GEN: https://t.co/KzqMccOt9Q
Joined April 2009
Magnesium Enables Immune Cells to Tackle Infections and Cancer. A new study has identified extracellular magnesium as a critical immune modulator of CD8+ T cells. Learn more:
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Peptide-Guided Nanoparticles Deliver mRNA to Neurons . Engineers say they have modified lipid nanoparticles (LNPs) to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons.
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đź‘€A sneak peek into the most anticipated #biotech event of the year! Don't miss your chance to hear Nobel laureate, Jennifer Doudna @doudna_lab discuss the evolution of #CRISPR over the years. FREE REGISTRATION:
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CRISPR Pioneers Doudna and Charpentier win 2020 Nobel Prize for Chemistry. Read more: #crispr #geneediting #nobelprize
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Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered. Researchers at @YaleMed have discovered that SARS-CoV-2 can directly infect the central nervous system. Read more: #SARSCoV2 #COVID19 #neuroscience
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Researchers have modified E. coli to produce chondroitin sulfate, which has been used as a dietary supplement for treating osteoarthritis. Learn more:
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Scientists in Japan say they have designed the first bottom-up peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. Read more: #drugdiscovery #nanotechnology
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CAR T Cells Generated In Vivo Reverse Fibrosis, Restore Cardiac Function in Mice with Heart Failure. Learn more:
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Can a bacterial toxin have a healing effect? . A team of researchers has found that the toxin α-hemolysin (Hla) from Staphylococcus aureus stimulates tissue regeneration. Learn more: #tissueregeneration #drugdiscovery #staph #inflammation
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Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms. Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: #neuroscience #alzheimers
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Scientists offer a new answer to solve a 100-year-old cancer mystery: The Warburg Effect. Read more: #cancer #warburgeffect
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Researchers from Columbia Engineering have developed a system that temporarily disguises therapeutic bacteria from immune systems and allows them to deliver drugs to tumors and kill cancer cells in mice. Learn more:
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Microwave Processing Isolates That Suppress Lung Cancer Metastasis. Scientists have developed a new microwave processing technology to isolate red ginseng compounds that effectively inhibit the metastasis of lung cancer. Read more:
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Researchers Flip the Switch on Immune Response in IBD. Researchers at KU Leuven and Seoul National University developed a method that instructs immune system cells to help repair damaged tissues in the intestine. Learn more:
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.@umichmedicine researchers report that 6-gingerol, the main bioactive compound in ginger root, has therapeutic effects against certain autoimmune diseases, including lupus and antiphospholipid syndrome (APS), in mice. Learn more:
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RNA Editing Is Having a Moment. Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
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A team of researchers used CRISPR to convert white fat cells into “beige” fat cells and then implanted the cells in mice models of breast and pancreatic cancer. The engineered fat cells outcompeted tumors for nutrients and reduced cancer progression.
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AAV Delivered NanoCas CRISPR System Edits Muscle in Non-Human Primates. Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.
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Tea compounds, ECG and EGCG, found in black and green tea have been found to relax blood vessels by activating ion channel proteins. These findings may lead to the development of new therapeutics for hypertension. Learn more:
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Researchers investigating the DNA outside our genes (the “dark genome”) report that they have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder. Learn more:
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People with diabetes have a higher risk of developing Alzheimer's disease (AD) raising a possible link between the cells that are disordered in diabetes—pancreatic β cells—and AD. A study reveals these cells may secrete neuroprotective factors.
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Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with diabetes by targeting the Enteric Nervous System. Learn more:
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Researchers Reveal How Killer T Cells Are Blocked from Fighting Cancer Cells. A new study by scientists at the @salkinstitute demonstrates how “bad fats” hinder killer T cells from fighting cancer cells. Learn how:
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Researchers Uncover Protein That Helps Tumors Evade Immune System. Researchers identify a protein called secreted gelsolin that aids tumors in evading the immune system. Learn more:
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Ribosomes Shown Translating mRNA from Maternally Inherited Mitochondrial Genome. Specialized mechanism for translation of the mitochondrial genome into proteins revealed. Learn more:
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Epigenetic DNA Methylation Imaged Directly in the Brain Using New eMRI Technique. Learn more:
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The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but. Read more: #genomics #sequencing
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Top Cancer Article of 2024: Readers' Choice—Tumors Have a Taste for Fructose, If It’s Transformed by the Liver. New research shows that fructose promotes tumor growth in multiple animal models of cancer after being converted by the liver.
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Genetics May Play a Role in Our Immune Response to Cancer Treatment. Researchers find Inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors. Read more:
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New gene and cell therapies are on the horizon to modulate the brain activity that causes the characteristic motor symptoms associated with Parkinson’s disease, heal the damage done to the brain, and even regrow lost neurons.
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Mark your calendars for Wednesday, March 16. Join us live at 2PM ET for our next episode of GEN Live "What COVID-19 Has Revealed about Science & Society". @PeterHotez Talks Anti-Science and How to Prevent the Next Pandemic. Register today: #COVID19
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Scientists at .@HopkinsMedicine say they have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. Learn more: #drugdelivery
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A team from @MIT describes a new CRISPR-Cas9 #genomeediting tool called PASTE, which delivered genes as long as 36,000 DNA base pairs to several types of human cells (as well as to liver cells in mice). Learn more: #CRISPR
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Structure of Key Parkinson's Disease Protein, PINK1, Seen for First Time. Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease. @WEHI_researc.
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Researchers have developed a new way to grow T cells in the lab that enables the cells to live longer and better destroy cancer cells in a mouse model of melanoma, compared with those cells grown using traditional growth media. @PittTweet @UPMCHillmanCC.
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Scientists have uncovered a new cell type in the human brain. They also found non-tumor cells that are neuron-glia hybrids, suggesting that this cell population may contribute to healthy brain function. Read more:
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#CRISPR Engineers a New Path for #Antibiotic Production. Scientists have discovered a new way of manipulating enzymes in bacteria, through #geneediting, which could create a new generation of antibiotics. Read more:
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Neural Stem Cells Decline During Aging. "Much work remains to be done, but this study marks exciting progress towards our goal of identifying prescription drugs that could rejuvenate our brains as we grow older. " Read more: #neuroscience #aging
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Personal Reflections on Five Years of COVID-19. Peter Hotez, MD, PhD, reflects on how it was the best of science and the worst of anti-science.
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First Synthetic Eukaryotic Genome Completed. The completion of chromosome synXVI allows scientists to explore new possibilities in metabolic engineering and strain optimization.
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Cannabidiol’s Antibiotic Potential Extends to Gram-Negative Bacteria. Read more: .#cannabis #antibiotics #bacteria
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First Genetically Engineered Pig Kidney Transplanted into Living Patient. The kidney transplant marks historic milestone and opens new frontier in transplantation to address kidney shortage affecting millions globally. Read more:
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PASTE, Don’t Cut: Genome Editing Tool Looks Beyond #CRISPR and Prime. A recently patented #genomeediting tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. Learn more:
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Alzheimer's Pathology Linked to Herpes Virus. A new study adds more evidence to the link between Alzheimer's disease and the herpes simplex virus-1. The study also revealed how tau protein might initially protect the brain from the virus.
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Proteins That Shape DNA Are Able to Shift Gears. A study reveals the structural maintenance of chromosomes proteins that shape our DNA can switch directions.
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Nanoimaging Gets Some Help from Graphene. Using a molecule called graphene, a single layer of carbon atoms arranged in a 2D honeycomb lattice, the researchers were able to coat cells and keep them alive and wet for much-improved imaging. Read more:
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AI Accelerates Enzyme Engineering. A new ML-guided platform can design thousands of new enzymes, predict how they will behave in the real world, and test their performance.
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A new tool for mitochondrial DNA mutagenesis has emerged—the double-stranded DNA deaminase (DddA)-derived cytosine base editor (DdCBE). Learn more:
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The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but. Read more: #genomics #sequencing
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Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein. Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1. Read more:
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A new CRISPR-Cas9 #genomeediting tool called PASTE, which can insert large pieces of DNA into several types of human cells, may be able to replace genes in a safer and more efficient way. Learn more: #CRISPR
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To restore vision in the blind, scientists have developed a wide-field, high-density and high-resolution photovoltaic prosthesis for the retina called POLYRETINA that can impart artificial vision. Learn more:
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2025 Trends: Organoids. The organoid market is expected to grow. Several R&D experts share their expectations for the next few years.
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🧬FREE VIRTUAL SUMMIT .Less than a week left before The State of #Biotech! Don't miss the opportunity to engage in conversations with world-renowned #scientists, entrepreneurs, inventors, and academics. Save your seat here:
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Scientists at the University of California, Irvine (UCI), and the Italian Institute of Technology have developed a new molecule, ALY101, that shows promising anticancer activity against a wide range of tumor cell types and in mouse models. Read more:
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Cancer Cells Metabolize Lipids Not Just for Fuel, but for Immune Evasion. Cancer cells can use lipids not just as fuel, but as a means to obscure inflammatory signals, enabling immune evasion. Read more:
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Blood-Brain Barrier Control Mechanism Could Point to CNS Therapeutic Strategies. Results from a new study could inform on how the microenvironment is important for blood-brain barrier maintenance. Learn more:
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Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms. Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: #neuroscience #alzheimers
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Improving CAR-T Cell Efficacy via New Manufacturing Process. A new bioprocessing technique developed by a team of researchers could improve a range of therapies based on CAR-T cells. Read more:
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Improving Cancer Immunotherapy by Blocking Glucose Supply. Memorial Sloan Kettering researchers report that immunotherapy may be improved by altering immune cells' access to sugar. Learn more:
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In a first-in-human clinical trial involving four adult glioblastoma patients, an mRNA cancer vaccine developed at the University of Florida (UF) reprogrammed the immune system to attack the tumors. Learn more:
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At @PennMedicine CAR T cells have been developed that can kill tumor cells in mouse models of neuroendocrine tumors and gastrointestinal cancers. Even better, the CAR T cells show no toxicity toward healthy epithelial cells. Read more:
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A new study by shows that up to 20% of #glioblastomas are powered by overactive #mitochondria and may be treatable with drugs currently in clinical trials. Learn more:
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Fanzor: First CRISPR-Like System Found in Eukaryotes. The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems. Learn more:
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Personal Reflections on Five Years of COVID-19. Peter Hotez, MD, PhD, reflects on how it was the best of science and the worst of anti-science.
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A new study reveals the presence of a fungus commonly found in foods like meat and cheese, preferentially localizes to injured and inflamed regions in the gut in patients with Crohn’s disease, preventing wound healing. Learn more:
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Scientists at @scrippsresearch and @disney_lab have developed a tool called Chem-CLIP-Fragment Mapping that bypasses "undruggable" proteins, and focuses on RNA to aid in drug discovery of incurable diseases. Read more: #breastcancer #RNA
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Researchers have solved the mysterious function of how MCM proteins protect the human cells against DNA instability, which can cause diseases including cancer. Learn more: Learn more:
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Targeted Protein Degradation: A Promising Option for Cancer Drug Developers. Instead of inhibiting disease-causing proteins, targeted protein degraders consign them to proteosomal and endolysosomal pathways. Learn more:
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Human Stem Cells Repair Retinas in Monkey Models of Macular Holes. Experiments in Japanese macaques showed that transplanting human embryonic stem cell organoid sheets resulted in successful hole closure.
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First Alzheimer's Disease #GeneSilencing Approach Lowers Tau Levels in Humans. Clinical trial results show promise for a new #genetic therapy for #Alzheimersdisease that lowers levels of the tau protein known to cause the disease. Learn more:
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Researchers at @UofT and @nyugrossman developed a novel #artificialintelligence technology, called ZFDesign, that can design #zincfinger proteins to target any stretch of DNA in the human genome. Learn more: #genetherapy #genetics #genomeediting
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Researchers develop a genome editing tool for the potential treatment of mitochondrial diseases:
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A new method combining sequencing and micro-imaging, developed by @MIT called in situ #genomesequencing, sequences DNA directly within intact biological samples and pinpoints where specific DNA sequences are located inside intact cells. Read more:
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Pin-point, a new base-editing system that uses RNA aptamers to localize DNA modifying effector enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic potential of #genomeediting, reported In @CRISPRjournal.
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Nanoparticle Platform Delivers siRNA Across the Blood-Brain Barrier in Traumatic Brain Injury Mouse Model. The delivery system showed 3Xs more accumulation in the brain than conventional methods. Learn more: #drugdelivery #neuroscience
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A team of researchers has succeeded in inhibiting the immune response induced by #AAV antibodies present as a result of natural immunity or following gene therapy. This result opens up new therapeutic prospects. Read more: #genetherapy
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#GeneEditing Startups Cut Fine Therapeutic Figures. New companies are exploiting next-generation #CRISPR technologies and powerful #CRISPR alternatives to realize new therapeutic approaches. Read more:
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Fructose is added to many of our foods and drinks. Unfortunately, excessive fructose in the brain may contribute to Alzheimer’s disease. Read more about .@CUAnschutz's findings : #alzheimers #diabetes
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CRISPR’s Tricks: How Cas Enzymes Capture, Trim, and Integrate Foreign DNA. New work from Jennifer Doudna’s lab could be useful for CRISPR-based technologies that seek to repurpose Cas1–Cas2 for molecular recording and information storage. Learn more:
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Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered. A new study from investigators at @YaleMed describes the mechanisms that allow the #coronavirus to directly infect the central nervous system. Read more: #SARSCoV2 #COVID19 #neuroscience
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Researchers led by Imperial College London have uncovered new insights into how bacteria hook up to exchange DNA that helps them resist antibiotics. Learn more:
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A novel tool has been developed to visualize the process of palmitoylation—the post-translational modification that allows peripheral membrane proteins (PMPs) to associate with cellular membranes—in living cells. Learn more:
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RNA Editing Is Having a Moment. Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more:
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Scientists from the Global Center for Biomedical Science and Engineering have discovered the mechanism by which molecules called Arl8b and BORC cause increased invasiveness and metastasis in radioresistant cancer cells. Learn more: #cancer #radiation
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