Matthieu Gélin
@GelinMatthieu
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Post-Doc @institutpasteur, Glioblastoma migration between @IP_BMcf and @etiennemannevil
Joined June 2019
Yasmine Belkaid sur la nécessité de préserver la recherche fondamentale : "Si on n'investit pas dans le début de la chaîne, il n'y a pas de chaîne", donc à terme pas de nouveaux médicaments ou traitements #le710Inter
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Yasmine Belkaid : "Il y a 0,3 % d’investissement en France pour la recherche fondamentale, contre 1 % en Allemagne : couper encore plus, c'est irresponsable. On va atteindre un point de non-retour." #le710Inter
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Starlink Mini offers fast, reliable internet on the go—great for traveling, camping, exploring, boating, RVing, and more. Stay connected without dead zones or slow speeds. Order online in under 2 minutes.
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The human haematopoietic niche: a minimalist approach Read this Research Highlight showcasing work from Adrian Candelas @adriancandelas, Manuel Théry @ManuelTHERY, Stephane Brunet @BrunetStphane7 & co.: https://t.co/u9mCnR3CAt 🎥Monitoring HSPCs divisions in microwell array
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🚨 PhD Opportunity: Apply for the Government of Ireland Postgraduate Scholarship! 🌟 Focus areas: active matter & microtubules. PM me by 8th Sept 2024 with your CV + research interests to explore this exciting opportunity! #PhD #Scholarship #ActiveMatter #Microtubules
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Yasmine Belkaid, directrice générale de l’Institut Pasteur : « Aujourd’hui, j’ai peur de perdre ce qui m’a fait choisir la France »
lemonde.fr
TRIBUNE. L’imunologiste à la tête de l’Institut Pasteur s’alarme, dans une tribune au « Monde », du coup d’arrêt porté à la recherche et la science, si un gouvernement limitait la circulation...
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Alexandre's magnum opus on centrosome positioning in adherent cells is out! 🔥 Big surprises for how centrosome centers with other-wordly scientific quality, amazing experiments and beautiful pictures.
biorxiv.org
The regulation of centrosome position is central to the establishment of polarized cell functions. This process is thought to rely on the generation of mechanical forces along microtubules, the...
I have been fooled by such images. They very much suggest that the balance of pulling forces along microtubules center the array. ...
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The debate was open. The centering of the array being visible in all cell lines, no one contested the founding hypothesis that a force balance in the microtubule array regulate its positioning. we now show it was wrong ! https://t.co/Cb25U1nw3F
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New preprint 🔥 my PhD swan song, with @BauschLab @hamfaizi @PVlahovska @HaganLab (+ Matt, Sarvesh Layne & Aparna) https://t.co/uVaq6sgNsq We put a microtubules+kinesin gel inside a GUV and... this happens: crazy fluctuations of a "cell" induced by a "minimal cytoskeleton"!
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@GelinMatthieu @ManuelTHERY and colleagues discover that when under mechanical pressure, microtubules can break into densely branched actin networks. Highlight: https://t.co/ukM6EvdvGB Article: https://t.co/9jO7oDT21j
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My PhD work is officially out in @J_Cell_Sci ! If you're interested in actin-microtubule interaction go give it a look ! Thx to all the people involved @christlet, @cguerin38, @gaillardjeremi1 and especially my two supervisors @Lblanchoin and @ManuelTHERY
https://t.co/2Z06jNbogU
journals.biologists.com
Highlighted Article: Microtubules under mechanical pressure can breach dense actin networks solely based on their polymerization forces. Mechanical pressure can be induced by mechanical hindrance or...
New CytoMorpho paper by @GelinMatthieu out in @J_Cell_Sci ! How do microtubules pierce the dense actin meshwork at cell periphery ? With cell images from @christlet, lipid micropattern by @cguerin38, microtubules by @gaillardjeremi1
https://t.co/N2z1FFWUxn
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Where does hematopoietic cell diversity come from? Asymmetric division is one of the answers. Can specific interactions govern the asymmetric division of the hematopoietic progenitors? Join me on my earliest journey!! Now on biorxiv!!!🧵🥰⬇️ https://t.co/rF0zsGnEmv
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Big thanks to Alexandre Schaeffer, @BenVianay, Jérémié Gaillard, Christophe Guérin, Marcus Braun, @christlet @Lblanchoin and @ManuelTHERY
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11/ If you are interested and want to know more about this work, you can find the full article here: https://t.co/HoyUG8auie.
biorxiv.org
The crosstalk between actin network and microtubules is key to the establishment of cell polarity. It ensures that the asymmetry of actin architec ture along cell periphery directs the organization...
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10/ While we continue to uncover the biochemical crosstalk between actin and microtubules, our study emphasizes the significance of their mechanical interactions. Further research could unveil the underlying mechanisms and their implications in cellular processes.
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9/ This mechanism may explain how microtubules progress towards the cell periphery, navigating through the denser parts of the actin network and playing a role in cell polarity establishment.
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8/ This immobilization can be the result of the anchorage of microtubules to an actin structure by crosslinkers, such as Tau.
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7/ Interestingly, we found that when microtubules are immobilized, the polymerization forces build up pressure within the microtubules. This pressure enables them to breach and penetrate the dense actin meshworks.
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6/ This suggests that the physical intertwining of the two networks regulates the spatial organization and force distribution within the microtubule network.
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4/ Our results showed that dynamic microtubules can align and move along linear bundles of actin filaments due to their polymerization force. Free microtubules are unable to penetrate a dense and branched actin meshwork but rather push against it.
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3/ To investigate this further, we developed an in vitro reconstitution assay based on a micropatterned lipid bilayer.
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