Setdb1 silences ERV derived cryptic enhancers to ensure proper hematopoiesis. Although transcription factors, such as PU.1, can bind to H3K9me3 heterochromatin, their activity is inhibited by Setdb1. out in PNAS:

H3K9me3 is not sufficient for silencing endogenous retroviruses if DNA methylation is perturbed. In Dnmt1 ko endoderm cells, IAP elements fully maintain H3K9me3, while trancriptionally active. great collaboration with @LickertHeiko. out in @NatureComms.

RT @generegulation: DNA sequence-dependent formation of heterochromatin nanodomains [Graeme Thorn, Christopher Clarkson, Anne Rademacher, H….

RT @M_Vincendeau: Here is our Snapshot of Human Endogenous Retroviruses (HERVs) that I wrote together with @JakobssonLab for Cell (@CellCel….

G-quadruplexes are cell type-specific and associated with high transcription. Great collaboration with @RichterLabUnipd @SaraNRichter_.

Morc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation. Morc3 GHKL ATPase domain dimerizes for Daxx interaction. An efficient ATPase cycle is critical for H3.3 incorporation.

HIV infection activates ERVs to regulate antiviral gene expression. Great collaboration headed by Daniel Sauter!

G4 quadruplex structures are cell type specific and associate with highly expressed genes. New preprint of a collaborative project led by @SaraNRichter_

RT @buschraml: Ever wonder why children react differently to pathogens? Join our lab and help us find out!

RT @JASN_News: The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Th….