Gerrit Poelarends
@GPoelarends
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Professor of Pharmaceutical Biotechnology Author of a Review on peroxygenases for oxyfunctionalization in Nature Catalysis. Read here: https://t.co/hVX6W2G56e
Joined June 2020
https://t.co/TsYAVZ8wty Pleased to share our latest work in @Nature. This paper wraps up our research at @ICIQchem , and I’m grateful for their incredible support! Looking forward to continuing the journey with the @MelchiorreGroup @Unibo !
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Enjoy reading our newest Review paper! Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives - Grandi - Angewandte Chemie International Edition - Wiley Online Library
onlinelibrary.wiley.com
Oxygenation and amination reactions are widespread in synthetic chemistry to produce valuable compounds. Nowadays, the importance of sustainable strategies to introduce oxygen and amino functionali...
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I hope you enjoy reading our newest paper on photobiocatalysis! Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light https://t.co/Ta0v5kuyZX
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Very pleased to announce that another great work from Poelarends’ group is out! I am glad to have been part of it! Go and check it! Many congratulations to my twitter-less colleague Marie-Cathérine Sigmund and all the coauthors @guangcai_xu @GPoelarends
chemistry-europe.onlinelibrary.wiley.com
Directed evolution of the cofactor-independent peroxyzyme 4-OT yielded an efficient biocatalyst (fused 4-OT P8a) for the enantioselective epoxidation of α,β-unsaturated aldehydes using hydrogen...
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I hope you enjoy reading our Minireview on recent advances in iminium biocatalysis Unlocking New Reactivities in Enzymes by Iminium Catalysis
pubmed.ncbi.nlm.nih.gov
The application of biocatalysis in conquering challenging synthesis requires the constant input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from synthetic chemistry has...
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Just accepted! More photoenzymatic work from our research group will be published soon. Chemo‐ and Enantioselective Photoenzymatic Ketone Reductions Using a Promiscuous Flavin‐dependent Nitroreductase
chemistry-europe.onlinelibrary.wiley.com
The enantioselective photoenzymatic reduction of a wide variety of ketones to the corresponding alcohols using the promiscuous nitroreductase BaNTR1 is reported. This flavoenzyme not only shows...
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Less structural symmetry, more functional diversity! Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C‐C Bond‐Forming Enzyme
onlinelibrary.wiley.com
Less symmetry, more diversity: Here we show that gene duplication and fusion to break structural symmetry, allowing independent sequence diversification of neighboring subunits by directed evolutio...
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Teaching DERA new tricks! Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution
pubs.acs.org
Class I aldolases catalyze asymmetric aldol addition reactions and have found extensive application in the biocatalytic synthesis of chiral β-hydroxy-carbonyl compounds. However, the usefulness of...
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Hot of the press: A perspective on sustainability in drug discovery! Read our article here: https://t.co/2DzVR78Kkq
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Biocatalytic Asymmetric Cyclopropanations via Enzyme‐bound Iminium Ion Intermediates
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I am glad to share with you our latest published @JMedChem results on Affinity-Based Fluorescent Probes of MIF for Competitive Binding Studies. Big thanks to @GPoelarends @wesleyrbrowne1 for support and valuable advice. https://t.co/BV1xhbZ4Mv
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Genetic regulation of gene expression of MIF family members in lung tissue
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Read our latest review paper entitled "Current state and future perspectives of engineered and artificial peroxygenases for the oxyfunctionalization of organic molecules", published with @SpringerNature in @NatureCatalysis
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"I am convinced that compromising ERC budgets will be disastrous for the future of Europe." - Ben Feringa https://t.co/XID7zq8INO
bbc.com
Sixteen thousand academics urge EU leaders to increase investment over the next seven years.
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Using Mutability Landscapes to Guide Enzyme Thermostabilization
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Another great review paper from the Bornscheuer group. Biocatalysis: Enzymatic Synthesis for Industrial Applications
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Identification of the AMA Synthase from the Aspergillomarasmine A Biosynthesis and Evaluation of Its Biocatalytic Potential https://t.co/MCnQXeRol3
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Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor‐Independent Non‐natural Peroxygenase
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Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds
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Check out some of the brilliant science presented in #BioTrans2019 in our joint #SpecialCollection with @ChemBioChem. It's #FreeToRead until the end of August! https://t.co/eGv1tUdqnh
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