Henry A. Dunn
@GPCRHenry
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GPCR lover. Pharmacology / Biochemistry / Neuroscience. PI @SBRC. Assistant Professor @UManitoba. Alumnus of @WesternU @uOttawa @ScrippsResearch @UF. 🇨🇦
Winnipeg, Manitoba
Joined May 2019
Very excited to share our most recent work describing ELFN2’s function in the brain as a novel transsynaptic modulator of group III mGluRs essential for tempering excitatory neurotransmission and neuropsychiatric behaviors in mice!
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RT @KLabGPCR: We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It….
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RT @KLabGPCR: Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses….
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RT @manitobaneuro: The 2024 MNN Research Symposium was a resounding success with ~180 Manitoban neuroscientists gathered for the latest in….
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RT @LorenaBAreal: First day back to work from maternity leave and starting a new job as a Research Associate @um_pharmacology. Lots of feel….
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RT @um_pharmacology: Congratulations to everyone who participated in the @umanitoba Undergraduate Research Showcase, especially the winners….
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Very disappointed to be cancelling my trip to the #2023GPCRRetreat tomorrow due to COVID. Was very much looking forward seeing everyone and returning to Montebello - a venue the retreat hadn’t been to in over 10 years and was one of my all time favourites. Enjoy, everyone!.
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An incredible study and resource with many important findings: including reclassification of group I mGluRs and some DREADDs, to name a few! Many congratulations to Kirill, Ikuo, and team.
Our systematic investigation of G protein coupling profiles of 100+ #GPCRs driven by the one and only Ikuo Masuho is out after ~10 years of work. We see many interesting patterns with the help of AI. Check it out- there is a useful reference table.
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RT @umanitoba: Congrats to UM’s Dr. Henry Dunn @GPCRHenry on being named a Future Leader in Canadian Brain Research. His research explores….
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Very pleased to receive this honour!.
Congratulations to the new cohort of Future Leaders in Canadian Brain Research! In its fourth year, @BrainCanada’s flagship program is providing funding to its largest-ever cohort of researchers, with 28 recipients! For more information ➡️
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RT @zenbrainest: The recent thread about diplomas in offices got me to thinking about two different offices I’ve visited. One was filled wi….
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Come join our Department!. Feel free to reach out to me with any questions!.
🚨 Calling all Cardiovascular Sciences experts! We're hiring a tenure-track/tenured Assistant/Associate Professor @um_pharmacology, @umanitoba! Develop your independent research program and contribute to our world-class research initiatives 🚨 #AcademicJob
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Can’t wait to see this in final form!.
Such a wonderful start of the day! Hang on as we are about to tell a story about #GPCR for neurotransmitter glycine. Happy Friday everybody! Work of the incredible scientist @ThibautLaboute.
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First day in the lab as a PI @SBRC and Assistant Professor @UManitoba where we’ll study GPCR pharmacology & neuropsychiatric disease! Excited to begin filling this lab with colleagues to share in GPCR enthusiasm - passed down to me from my mentors @FergusonottawaS and @KLabGPCR!
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A compelling trafficking study demonstrating mGluR7 mobility and subsynaptic localization are predominantly regulated by it’s extracellular domain - suggestive of the integral role of trans-synaptic interactors (like ELFNs) in group III mGluR biology. Glad to see this published!.
Finally it is out! Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions.
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I've just registered for the GPCR Retreat and I couldn't be more thrilled! I haven't missed one since my first attendance in 2008 and it feels extra personalized this year with my mentors @FergusonottawaS and @KLabGPCR as Keynotes. Looking forward to seeing everyone in person!.
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It’s been incredible watching this develop! Congratulations to all involved, especially @Dipak_P_tsri and @KLabGPCR!.
Can a #GPCR structure still surprise you? Happy to present #CryoEM structure of an orphan receptor GPR158. Couples to RGS instead of G proteins. Features an extracellular Cache domain for ligand binding.Forms a unique tight dimer stapled by phospholipids
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RT @LorenaBAreal: Please RT if you know someone who has students in grades 6-8. With our current online format we are able to accept studen….
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Another fascinating example of how Class A GPCRs, despite possessing relatively little extracellular real-estate, are critically modulated by their extracellular protein environment!
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