Ole Fröbert
@FrobertOle
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Cardiologist/researcher, clinical trialist. Evidence and plant based
Aarhus, Danmark
Joined June 2018
Keeping up with this topic is really exhausting. Stop everything—here’s a new meta-analysis, this time in patients with myocardial infarction and preserved ejection fraction (≥50%). The first piece of news is that, after I don’t know how many years since the last cardiovascular
nejm.org
The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient le...
I wouldn’t exactly call myself a black belt in beta-blockers, but with all this talk of superiority, "non-superiority," and "non-non-inferiority," it’s really enough to get confused. If I interpret correctly the avalanche of trials from the past year, accompanied by the
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Spoke at Charité Berlin today. Protect yourself and your patients with a flu shot, not with RFK Jr.’s wellness insights @DavidAgus @DLBHATTMD @DrEricDing @Tobjizzle @SVRaoMD @DGlaucomflecken @drjohnm @PeterHotez
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Do p-tau217 levels rise without amyloid or tau aggregates? 🐻 In our Acta Neuropathologica paper, we show that 🩸 p-tau217 increases ~300% during bear hibernation, while hibernating hamsters also show ⬆️ p-tau but no changes in MTBR tau. https://t.co/8QgRj9hfR9
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Bears tolerate ventricular tachycardia while humans don’t. Our newly published findings have biomimetic potential for humans. @Lpa_Doc @GreggWStone @gunnar_heine @cpgale3 @SVRaoMD @ItaiYanai
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Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement just published in EHJ. https://t.co/q5m1Dqb45w
@ESCardio @ESC_Journals #vaccines
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💉 Influenza vaccination as cardiovascular prevention – the evidence is growing. Co-authored with @FrobertOle, and collegues – our new review in Atherosclerosis highlights the data behind flu shots reducing CV events. 🧠 Simple, low-cost, life-saving. https://t.co/6J1aiEaIGu
atherosclerosis-journal.com
Influenza infection is a well-established trigger of acute cardiovascular events, particularly myocardial infarction, mediated by systemic inflammation, endothelial dysfunction, and thrombosis. In...
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2nd new PROSPECT II publ, this in JACC Int: hs-CRP (inflammation) was independently associated with both diffuse cor plaque and lipid deposition as well as focal vulnerable plaques. Coupled with the JACC article: LDL & CRP → diffuse plaque and lipid whereas Lp[a] & CRP → VP.
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We have a new Lp(a) paper, led by @derlinge from PROSPECT 2 using IVUS/NIRS. It shows high Lp(a) associates most with vulnerable plaque characteristics, whereas LDL-C with plaque burden. Lp(a) was measured by our @UCSDCardiology assay, the only Lp(a) assay I am aware of that is
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We just published: In NSTEMI, high hsCRP is associated with pan-coronary atherosclerosis and focal high-risk plaques Out now in JACC Cardiov Int (link below) @GreggWStone @MaeharaAkiko @SVRaoMD @DavidErlinge @DLBHATTMD @MGtberg @cpgale3
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Published a letter in @TheEconomist
@mmamas1973 @SVRaoMD @cpgale3 @DavidLBrownMD @drjohnm @Lpa_Doc @NielsRHolm
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Our 2021 IAMI flu vaccine trial continues to make waves - first shaping European guidelines with a 1A recommendation, now the same in the American version. @SVRaoMD @Globalbiosec @mmamas1973 @MGtberg @drjohnm @DLBHATTMD @StabellBenn @cpgale3 @DrMarthaGulati @LGHemkens
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This #JACCINT analysis of 42,887 patients from the #SWEDEHEART registry shows comparable rates of #MACE (31.3% vs. 32.2%) between IFR vs FFR-guided #PCI and no difference in all-cause mortality over 5 years. https://t.co/P0vATOsgpQ
@MGtberg
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We are looking for a PhD student, with an interest in skeletal muscle physiology and stem cell biology, to conduct a trial in elderly subjects. Preferably with an MD background since the trial will involve a number of invasive procedures 🧑🏫 Please share and reach out…
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1/2 Finally we can share this now published analysis of iFR vs. FFR and outcome from Swedeheart registry. In all 3 different models we find similar outcome. No signal of increased mortality. This should put the debate of between iFR and FFR at rest.
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Happy New Year everyone from the PCI team mending broken hearts in Örebro, Sweden 🥳
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A new type of coronary stent breaks the deadlock in outcome improvement after percutaneous coronary intervention!
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Bears are amazing and offer valuable lessons for our lifestyle. My debut book is launching soon—grab your copy today! This exclusive first edition is bound to increase in value and ignite your curiosity about nature’s marvels.
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