Fischbach Lab
@FischbachLab
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Lab of Dr. Claudia Fischbach @CornellBME. We apply engineering principles to understand how tissue microenvironments influence cancer. Tweets by lab members.
Ithaca, NY
Joined August 2022
Preprint alert! Excited to share our new manuscript from @CornellBME @GarrettBeeghly examining how the size of fat cells, or adipocytes, impacts breast cancer risk. We found that larger adipocytes promote aggressive behavior in tumor cells. 1/5
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RT @biorxiv_cellbio: Hypertrophic adipocytes increase extracellular vesicle-mediated lipid release and reprogram breast cancer cell metabol….
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Ultimately, our findings suggest that larger adipocytes are a distinct cell population within adipose tissue and increase lipid transfer to invading cancer cells. As a result, we propose that adipocyte size could be a valuable prognostic biomarker for breast cancer patients. 5/5.
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In a published cohort of mastectomy patients, we found that average adipocyte size predicted dyslipidemia and circulating triglycerides more than BMI. These results suggest that altered lipid release by larger adipocytes may also have implications for whole body metabolism. 4/5.
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Functionally, larger adipocytes increase a non-canonical, vesicle-mediated mode of lipid release versus lipolysis. This shift promotes lipid transfer to nearby breast cancer cells, increasing their migration and proliferation in a manner dependent on fatty acid metabolism. 3/5.
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Here, we developed methods to sort and culture primary adipocytes isolated from the same adipose tissue. We determined larger adipocytes are transcriptionally distinct from smaller donor-matched cells and are enriched for gene sets related to altered lipid processing. 2/5.
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RT @KoladeAdebowal1: Thanks @FischbachLab for accepting our invitation and giving an excellent keynote to kick off the 2025 GRS Physical S….
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Check out our latest publication in @Biomaterials_ on how mineralized scaffolds alter the microenvironmental composition of pre-clinical tumor models:
Scaffold design and choice of animal model drastically affect tissue formation and cellular complexity impressively shown in our new @Biomaterials_ paper by @Matt_AWhit and @mantri_madhav with @IwijnDeVlaminck @CornellBME .
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RT @GarrettBeeghly: Feeling extremely grateful to have completed my PhD with so much support from @CornellBME, @FischbachLab, and my fantas….
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RT @fischbcl17: Congratulations @GarrettBeeghly on a fantastic defense and significantly advancing our understanding of adipocytes and thei….
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RT @fischbcl17: Couldn’t have asked for a more perfect day for @FischbachLab apple picking @CornellBME
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Going to the @BMESociety Annual Meeting in Baltimore next week? Check out these @FischbachLab presentations and posters! And stop by the @CornellBME booth to learn more about our graduate MEng and PhD programs
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Thank you to @LammerdingLab and @FischbachLab bakers and everyone else who made the fundraiser our most successful year yet! We raised over $1100 for @CancerResource. Make sure to check out all the amazing work the CRC does at
Hungry and on the Cornell campus? Enjoy some delicious cookies and other baked goods to raise funds for the Cancer Resource Center of the Finger Lakes. And a big shoutout to all the lab members for their amazing baking skills!.
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RT @GarrettBeeghly: Made chocolate caneles for our annual @CancerCornell bake sale fundraiser for the @CancerResource Center of the Finger….
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RT @fischbcl17: Ever had Gochujang cookies? Come and get some (or other delicious items) today at bake sale in Weill Hall @CornellBME in….
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RT @bobriter: Members of the @FischbachLab and the @LammerdingLab out in force at today’s Walkathon and 5K run in support of the @Canc….
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RT @CornellBME: We're Hiring! Seeking a Tenure Track Faculty Position in Biomedical Engineering, @Cornell @CornellEng @CornellBME #BME. Le….
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And we got to try the Gewürztraminer harvest straight from the vine at HJW!
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We got to enjoy the beautiful weather over the weekend as part of the inaugural @FischbachLab wine tour. There’s lots to do and see in the Finger Lakes besides science! Apple picking is up next…
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