The Fehr Lab
@FehrLab
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Joined December 2017
RT @jakescottMD: 1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?”.RFK Jr: “The truth is, I don….
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RT @JUHesssss: Congrats to everyone in the latest Biohawker Monthly. @FehrLab has two publications in this month's edition. #ThatsFehr #KUM….
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RT @BUSShowcase: Darin Fehr (@DarinFehr2) shows off an explosive arm for @YardBallClub. 6'4 205lbs RHP from Lawrence, KS. #Uncommitted 2026….
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Just got this published! Congrats to all involved especially first author Jessica Pfannenstiel! @KUbiology @pshefty @KUMolBio.
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Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication | mBio
journals.asm.org
Coronaviruses (CoVs) present significant threats to human and animal health, as evidenced by recent outbreaks of MERS-CoV and SARS-CoV-2. CoVs encode for a highly conserved macrodomain protein (Mac1)...
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RT @dr_andrealove: Vaccines don’t cause autism. Vaccines aren’t even associated with autism. The biggest predictor of autism?.GENETICS.….
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RT @CameronLabUNC: Virology lost a giant last week. I and so many others have lost an advocate, mentor and friend. RIP, Ann. 💔 https://t.c….
cressfuneralservice.com
View Ann Carol Palmenberg, Ph.D's obituary, find service dates, and sign the guestbook.
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RT @brainaddiction: It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study pu….
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RT @KUbiology: @FehrLab was awarded the Presidential Early Career Award for Scientists and Engineers (PECASE) for his research contributi….
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RT @dr_andrealove: The MAHA crew wants to “ban glyphosate” - which isn’t surprising considering that RFK Jr. was on the legal team for the….
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@JUHesssss @LabLehtio And of course great effort from our core facilities. @KUCollege @KUnews @ResearchAtKU @KUDACB @KUMolBio @KUbiology.
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We’ve just posted our newest chapter in our effort to develop Mac1 inhibitors. We identified several Mac1 targeting compounds with antiviral activity. Fantastic work by @JUHesssss and our collaborators @LabLehtio and Dana Ferraris!.
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Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
biorxiv.org
Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target...
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@KUCollege @ResearchAtKU @KUnews @KUDACB @pshefty @KUMolBio .Just published in JVI, new research from our lab on how the CoV macrodomain controls its ADP-ribose binding for the benefit of the virus! Huge effort from both my lab and the CBID-COBRE core facilities!.
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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication | Journal of Virology
journals.asm.org
The conserved coronavirus (CoV) macrodomain (Mac1) counters the activity of host ADP-ribosyltransferases and is critical for CoV replication and pathogenesis. As such, Mac1 is a potential therapeutic...
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RT @SunnyShinLab: Congratulations Susan Weiss @weisssr @PennMicro on receiving the @ASMicrobiology Lifetime Achievement Award! Such well-de….
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