Fasan Lab
@FasanLab
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At @UTDallasChemBio, we design & develop novel chemo-biosynthetic and chemo-enzymatic strategies for the discovery of biologically active molecules
Richardson, TX
Joined June 2017
Delighted to share our paper just appeared in Chemical Science on the discovery of macrocyclic peptides targeted against an RNA motif from SARS-CoV-2! Congrats to Jake, Andrew, and Abhijith @UT_Dallas and great collab with Wedeking group @URochester_SMD
https://t.co/MfqdrT1C6f
pubs.rsc.org
RNA provides the genetic blueprint for many pathogenic viruses, including SARS-CoV-2. The propensity of RNA to fold into specific tertiary structures enables the biomolecular recognition of cavities...
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@FasanLab @UT_Dallas develops a new powerful method for skeletal editing of complex natural products at aliphatic C-H sites by combining site-selective and tunable enzymatic hydroxylation with chemical oxidation/ring expansion. Read on: •
onlinelibrary.wiley.com
A chemoenzymatic strategy is reported for enabling skeletal editing of a target molecule via ring expansion at the level of one or more aliphatic C─H sites. By combining P450-mediated site-selective...
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Very grateful to Benjamin List and Kateryna Kryvous for selecting our paper on a photobiocatalytic strategy for C(sp3)-H acylation for a highlight in Synfacts! 🙏 🙏 https://t.co/yZDkcw2AYL
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Check out our paper just published in @angew_chem on a chemoenzymatic strategy for ‘skeletal editing’ of complex molecules with engineered P450s! Big congrats to John Bennett, Andrew Bortz, Zheyuan Wang, & Muhammed Fastheem for the excellent work! https://t.co/pntFf2Cvvd
onlinelibrary.wiley.com
A chemoenzymatic strategy is reported for enabling skeletal editing of a target molecule via ring expansion at the level of one or more aliphatic C─H sites. By combining P450-mediated site-selective...
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Congratulations to @Yining_Wang_ in the @FasanLab at @UT_Dallas for passing his qualifying exam! He is now officially a PhD candidate! Way to go, Yining! 👏👏
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Kudos to our Clark summer research fellows Gianna Eckerle and Andy (Anh Triet) Tran for doing a great job at presenting their research projects at the SURP Symposium @UT_Dallas!
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Check out our paper on stereoselective synthesis of halogenated cyclopropanes via biocatalytic cyclopropanation! Kudos to lab members Ron Adukure and Muhammed Fastheem and big thanks to our collab Tay Rosenthal, Matt Robinson & team at Corteva Agriscience! https://t.co/LP4z1N7dOy
chemistry-europe.onlinelibrary.wiley.com
A biocatalytic strategy was developed for the synthesis of enantioenriched halogenated cyclopropanes via enzyme-catalyzed cyclopropanation of chloro- and bromo-substituted olefins in the presence of...
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We are hiring! Multiple postdoctoral positions are available in our lab in the areas of biocatalysis, protein engineering/design, and peptide/protein therapeutics: https://t.co/eN4eAZVgs3 Interested candidates should email the PI with CV and cover letter. Please spread the word!
jobs.utdallas.edu
Multiple postdoctoral positions (up to 4) in the areas of peptide chemistry/engineering, protein engineering/design, and biocatalysis are available in the laboratory of Rudi Fasan in the Department...
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Photobiocatalytic Enantioselective Benzylic C(sp3)–H Acylation Enabled by Thiamine-Dependent Enzymes via Intermolecular Hydrogen Atom Transfer | Journal of the American Chemical Society
pubs.acs.org
Hydrogen atom transfer (HAT) constitutes a powerful mechanism exploited in biology and chemistry to functionalize ubiquitous C(sp3)–H bonds in organic molecules. Despite its synthetic potential,...
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On the International Day of Women and Girls in Science, a big shoutout to all the women in the @FasanLab @UTDallasChemBio for their outstanding contributions to our science! Go Aanu, Anwita, Elanor, Francesca, Hiram, Mary, Marriah, Michelle, Pamela, Ru, Shreya, and Yashika!🦾🎉
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Congrats to Jadab @majhijadab , Saty, and Anwita @Anwita_Ch for their recent paper in @ACSCatalysis on a new biocatalytic strategy for the asymmetric synthesis of oxazolidinones via intramolecular C-H amination with engineered myoglobins! Great job! 🎉👏 https://t.co/gBwM44CDxF
pubs.acs.org
Oxazolidinones are important heterocycles widely utilized in medicinal chemistry for the synthesis of antifungals, antibacterials, and other bioactive compounds and in organic chemistry as chiral...
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Happy to share our recent paper on the regiodivergent C(sp3)–H functionalization of indolines via enzymatic carbene transfer in @ChemCatalysis Big kudos to lead authors Bo Couture and Ru Cui for the excellent work!🎉
cell.com
This work reports the development of an efficient biocatalytic strategy for the stereoselective and regiodivergent C(sp3)–H functionalization of N-substituted indolines, a privileged scaffold in...
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We are hiring! Our Department of Chemistry and Biochemistry at @UT_Dallas has two open-rank faculty positions in the areas of Biochemistry and Inorganic Chemistry, broadly defined. Come join a dynamic and vibrant department! https://t.co/VmIefVAmko
https://t.co/R6p3QJ9l4s
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Excited to see our recent paper on chemoenzymatic DOS using engineered P450 enzymes highlighted in Chemical & Engineering News! https://t.co/9groy9GEDj Many thanks to Brianna Barbu for the great cover article and to Robert Huigens for the enthusiastic comments on our work!
cen.acs.org
Researchers transform a single precursor molecule into 51 new and diverse structures
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Delighted to share our latest work on a Chemoenzymatic Diversity-Oriented Synthesis strategy for generating complex, natural-product-like compounds with enzymes. Big 👏to the lead authors Andrew Bortz and John Bennett for this beautiful work!🎉 https://t.co/45xnT3n2tJ
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Great representation of the Fasan lab at #ACSFall2024 Postdoc Jadab Majhi @majhijadab & grad students Anwita Chattopadhyay @Anwita_Chand and Ron Adukure will present new biocatalytic strategies for the stereoselective synthesis of lactones, aminals, and halogenated cyclopropanes
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Congrats to our Anwita Chattopadhyay @Anwita_Ch for receiving a travel award from the ACS Division of Organic Chemistry to present at the #ACSFall2024! Thanks to the ACS DOC for their support and kudos to Anwita and fellow awardees!
Congratulations to the Division of Organic Chemistry Fall 2024 ACS Travel Awardees (pictured with the Chair of the Awards Committee, Prof. Michael Pirrung).
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Congrats to our postdoc @majhijadab (left in the pic) for receiving UT Dallas Provost’s Office Postdoctoral Appreciation Award! Jadab will present his research at the 2024 ACS Fall meeting and at the Postdoctoral Research Symposium at UT San Antonio (Sept. 16). Way to go, Jadab!
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Check out our latest work on the stereoselective synthesis of pyridyl-cyclopropanes via enzymatic activation of pyridotriazoles just published in @J_A_C_S ! Congrats to @Satyajit_chem Yining Wang and rest of team @UTDallasChemBio @FollowStevens!
pubs.acs.org
Hemoproteins have recently emerged as powerful biocatalysts for new-to-nature carbene transfer reactions. Despite this progress, these strategies have remained largely limited to diazo-based carbene...
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