The Fang Lab
@Fang_Lab
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Studying vascular biology and cell-cell signaling in microphysiological organ-on-a-chip systems and mouse models. Doing science at @Tulane!
Joined November 2021
We are so excited to finally share our first paper out of the lab, a review on Cx37’s role as a cell cycle regulator in the vasculature, published today in JVR. This paper was truly a labor of love! https://t.co/uQWfdSiKO7
karger.com
Abstract. Control of vascular cell growth responses is critical for development and maintenance of a healthy vasculature. Connexins – the proteins comprising gap junction channels – are key regulat...
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When we started in this #menopause #sexdifferences space ~20 yrs ago reviewers comments included “as nephrologists, whether patient is male or female not important or relevant”, so you can imagine our grant significance scores 😱 We have come a long way! ❤️ @NIDDKgov @ASNKidney
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Large-pore connexin hemichannels function like molecule transporters independent of ion conduction | PNAS
pnas.org
Connexin hemichannels were identified as the first members of the eukaryotic large-pore channel family that mediate permeation of both atomic ions ...
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Visiting the original home of the Fang lab before they renovate and redo it!
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Thankful to be able to present my PhD work on a novel PANX1 isoform at @igjc2024
Great job Dr Brooke O'Donnell! Thanks for your talk titled "Novel Pannexin 1 isoform is increased in cancer"
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This review paper was written in collaboration with Dr. Mark Mondrinos, our collaborator in the @Tulane Dept. of Biomedical Engineering. In this paper, we discuss importance, strategies, and challenges for incorporating physiological hemodynamic flow in vessel-on-a-chip systems
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We are excited to announce publication of our lab's latest review paper: "Capturing physiological hemodynamic flow and mechanosensitive cell signaling in vessel-on-a-chip platforms", part of Mechanotransduction in Vascular Development and Disease topic https://t.co/ibBFmPSILF
frontiersin.org
Recent advances in organ chip (or, "organ-on-a-chip") technologies and microphysiological systems (MPS) have enabled in vitro investigation of endothelial ce...
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Happy to see this one out in the world after a mammoth effort. If you like c-Src (who doesn’t?!) and watching vessels blow up like a balloon, this one is for you! Thanks to @J_Cell_Sci, who made this a delightful process.
journals.biologists.com
Highlighted Article: Constitutively active c-Src (Y527F) in 3D vascular models induces a ballooning phenotype due to local secretion of MMPs at focal adhesions in endothelial cells.
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June 23rd is Global HHT Awareness Day. It's not a date that was chosen at random. June 23rd is Grace Nolan's birthday, who tragically passed away from HHT at 9 years old. Let's get loud this Sunday and spread life-saving awareness
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Double the impact of your gift TODAY and TODAY only! On Global HHT Awareness Day, The Grace Nolan Foundation has generously agreed to match the first $25,000 we raise. Please consider giving generously to fuel our mission to create change within HHT: https://t.co/fwnrD7VdIL.
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New #Postdoc position available in my lab @LSUHS studying novel regulators of smooth muscle phenotype in #atherosclerosis. Strong training environment @LSUHS_CCDS with intramural Fellowships/Transition Grants and Career Development Workshops. Send CVs to wayne.orr@lsuhs.edu
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Congratulations to Rebecca Horowitz 🙌 👏 an MD PhD student in our lab in collaboration with @JMactheyounger and trainee on @UAB_NRTC T32 @NIDDKgov @uabmedicine @TulaneMedicine @GotTcells @davidpollock929
Congratulations Rebecca Horowitz!!! We want to recognize Rebecca for her hard work at this year's William Schnaper Visiting Scientist (WSVS) TL1 Spring 2024 Mini-Symposium @McLachlanLab @AJPRenalEIC
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So thankful for @_LSEFoundation_ & @LSE_editors @LSE_Angela who are committed to supporting scientists of all backgrounds and career stages. I was honored to receive a JEDI award and extremely proud of the science we communicated @jclinicalinvest
https://t.co/3SNxo7ot43
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Excited to share our work on TRPV4 in lymphatic contractile function! @CastorenaLab
TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells https://t.co/cTOld8TYpm
#bioRxiv
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Very excited and proud to see our research @DOM_UCLA online @jclinicalinvest Check out the flow polarized signaling domains in endothelial cells captured by @SoongookHong
Excited to announce that our current work has been accepted in the Journal of Clinical Investigation (JCI) and are now available as a In-press preview on the website! Check out our beautiful videos in the supplemental data section :) https://t.co/JSe6ifmLFV
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This year's LCRC Scientific Retreat offered a new format that attracted a record number of attendees. Nineteen presentations were offered, each focused on ways to prevent, diagnose, treat, and survive cancer.
louisianacancercenter.org
Promoting education and conducting research in the diagnosis, detection and treatment of cancer in Louisiana.
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Congratulations to our graduate student Kapil Thapa for receiving an Honorable Mention award for his poster presented at the @Tulane Research, Innovation and Creativity Summit (TRICS)! https://t.co/oyBoZF7uAv
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NIH to increase pay for predoctoral and postdoctoral NRSA. Predocs now earn will go up 4% and postdocs will start at $61,008 (+8%), with more based on experience. Also boosting childcare subsidies and funds for training expenses. https://t.co/wVwgwltuwY
nih.gov
Increase applies to more than 17,000 research trainees and includes additional funds for childcare and training-related expenses.
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Eagle-eyed readers will see graduate student Edward working at the dissection scope, and lab manager Hannah and undergraduate student Brandon having a meeting in the open desk space adjacent to the lab. Bonus points for spotting Dr. Fang’s lab coat!
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