Brooke O’Donnell
@b_odonnell17
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PhD👩🏼🔬🇨🇦 | Post-doctoral Fellow | Isakson Laboratory | University of Virginia 🧡💙 (she/her) @brookeodonnell.bsky.social
Joined September 2021
Thrilled to share the second paper published from my PhD work investigating how PANX1 and PANX3 regulate the cancer cell properties of cutaneous squamous cell carcinoma 🧵/1
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RT @EvaYHChiu: Well, I guess this might be the best way to celebrate the end of 2024 and welcome the new year of 2025:. .
advanced.onlinelibrary.wiley.com
This study employs a hit-to-lead optimization strategy and identifies a new Pannexin 1 inhibitor with markedly improved specificity and potency than the traditional inhibitors. It also delineates...
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Thoroughly enjoyed my first vascular conference at ISRA in Helsingør, Denmark where I shared our work on the physiological roles of PANX1 phosphorylation in the vasculature. Thank you to the organizers for the opportunity! @2024_ISRA #ISRA2024
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PANX1 deletion or channel inhibition reduced SCC-13 cancer cell properties of SCC-13 such as growth and migration. Conversely, global Panx3 KO mice subjected to the DMBA/TPA cutaneous carcinogenesis model had increased papilloma growth and incidence. 🧵/end.
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Within the tumour, PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour stroma which contains tumour-infiltrating lymphocytes, cancer-associated fibroblasts and blood vessels. 🧵/4.
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We found that PANX1 and PANX3 show opposite expression patterns in patient-derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. 🧵/3.
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Thank you to my amazing mentor @DrSilviaPenuela who said yes to my idea and supported me throughout this project and the people who made this work possible @skl_sam @DanStefan_ @Path_Matt 🧵/2.
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RT @MikeGoldVan: This is going to be a great meeting. Terrific speakers, friendly atmosphere, lots of trainees, and a beautiful location. C….
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RT @ctr_springer: Call for Papers: Connexins, Innexins, and Pannexins: From Structure to Physiology. Curated by Dr. Trond Aasen, Dr. James….
link.springer.com
Cell and Tissue Research is a scholarly forum publishing articles in the fields of molecular, cell, and supracellular biology. Provides thorough coverage ...
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RT @DrSilviaPenuela: @ScottRJ_VT @WesternU @VirginiaTechCPE Specially proud of my lab team for their presentations and awards for @b_odonne….
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RT @DrSilviaPenuela: And it’s a wrap! Thank you for participating and attending @IGJC2024 You made 3 years of planning and organizing #IGJC….
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What a great way to kick off a new chapter at UVA with @conn_pann_fun. Thanks to the organizers for allowing me to talk about our exciting new work on the physiological specific roles of different PANX1 phosphorylation sites.
Well done on your talk today Dr Brooke O'Donnell and best of luck in your new appointment with @conn_pann_fun !."Physiologically specific roles for post-translational modifications of .Pannexin 1"
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Thankful to be able to present my PhD work on a novel PANX1 isoform at @igjc2024.
Great job Dr Brooke O'Donnell! Thanks for your talk titled "Novel Pannexin 1 isoform is increased in cancer"
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RT @igjc2024: All trainees are welcome to attend the workshop at 3pm in the F. Scott Fitzgerald ballroom on the second floor at the Westin….
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RT @igjc2024: @DrSilviaPenuela lab has landed!.Don't forget to tag @igjc2024 and use the #IGJC2024 hashtag in your IGJC2024 posts. We're lo….
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RT @DrSilviaPenuela: Very proud of the Penuela Lab awardees at the @westernuACB annual awards today! Dr Brooke O’Donnell won best publicati….
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Incredibly grateful for an amazing mentor @DrSilviaPenuela and lab family❤️.
Proud to present the newly minted Dr. Brooke O’Donnell @b_odonnell17 after her stellar PhD defense on Friday. Congratulations! 🎉
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