Fabio Boniolo
@FabioZB_I
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Engineering any human tissue, of any size, shape, and geometry https://t.co/o6tCmJqLNZ Prev @broadinstitute and @DanaFarber
New York City, NY
Joined September 2019
I was in awe the first time I heard about the idea of engineering living replacement grafts to cure disease and trauma. Doing so at scale can change the way we treat and prevent damage. The stakes are high and the problem is complex but our data show that it is tractable. We
polyphron.com
We are building a scalable tissue foundry. The platform will be able to engineer any human tissue of any size or complexity.
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Love this idea: learning the general rules of morphogenesis to guide the design of new living structures. The first step is to recapitulate naturally existing ones, faster and more efficiently. Studies like this one show that we now have the tools to do so.
@BioSignal Inded, thank you! This feature is key to why this approach helps not just in understanding the principles of development but also in designing synthetic systems. Knowing the 'generative rules' of these local interactions enables us to move closer to de novo design of
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why cant i just fix tissue damage by squeezing in a tub of progenitor/stem cells into the site of the damage and let the body deal with it
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clip topic: how do you grow human tissue ex-vivo? or at least, how does Polyphron do it? tldr: fill a box with X scaffold, seed it with iPSC's, stare at developmental cell atlases, introduce in the same set of ligands into the box (along w/ a standard cell-differentiation
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it’s rare there’s such futurism mixed with tactical and tangible scientific results and path forward. Highly rec.
What if we could grow human tissue by recapitulating embryogenesis? This is an interview with Matthew Osman (@thematthewosman and Fabio Boniolo (@FabioZB_I), the co-founders of Polyphron. (Links in reply) The thesis behind Polyphron is equal parts nauseating and exciting in
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Are you curious about how you would make an AI-driven tissue foundry work both technically & commercially? Then this should be a great listen - was a delight chatting to @owl_posting, he put us through our paces!
What if we could grow human tissue by recapitulating embryogenesis? This is an interview with Matthew Osman (@thematthewosman and Fabio Boniolo (@FabioZB_I), the co-founders of Polyphron. (Links in reply) The thesis behind Polyphron is equal parts nauseating and exciting in
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Thank you @owl_posting for hosting my cofounder, my accent, and me on the podcast. A really fun and engaging discussion on the technical and strategic bottlenecks in tissue engineering and how Polyphron is addressing them, one by one. and thanks to @LatchBio for sponsoring the
What if we could grow human tissue by recapitulating embryogenesis? This is an interview with Matthew Osman (@thematthewosman and Fabio Boniolo (@FabioZB_I), the co-founders of Polyphron. (Links in reply) The thesis behind Polyphron is equal parts nauseating and exciting in
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Are we building a thing like Wired back when Wired was cool. I think we are
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Yes - Tissue engineering is hard but solving it could fundamentally change the way we look at prevention and treatment. We are building the technology to make that a reality. Excited for everyone to listen to the next @owl_posting episode tomorrow. This was fun!
great essay by @ashleevance you should read it! because tomorrow morning, i will release a two hour long podcast discussing the economics, prior failed approaches, and science of how tissue engineering works at Polyphron, filmed with the founders @thematthewosman and @FabioZB_I
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Couldn’t be more excited for this podcast drop tomorrow between @owl_posting and @thematthewosman and @FabioZB_I. Tissue engineering is coming and Matt and Fabio are making it work with Polyphron.
great essay by @ashleevance you should read it! because tomorrow morning, i will release a two hour long podcast discussing the economics, prior failed approaches, and science of how tissue engineering works at Polyphron, filmed with the founders @thematthewosman and @FabioZB_I
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Owl pod incoming on Polyphron. set your alarms.
great essay by @ashleevance you should read it! because tomorrow morning, i will release a two hour long podcast discussing the economics, prior failed approaches, and science of how tissue engineering works at Polyphron, filmed with the founders @thematthewosman and @FabioZB_I
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One thing I didn’t fully appreciate about building a new technology platform from scratch is the deep sense of satisfaction when the first meaningful, high-signal results start to roll in. Exhilarating.
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Gene edits change instructions. Drugs change behavior. Neither reconstructs multicellular structure. That’s the gap tissue engineering must fill.
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I recommend biology for anyone who is looking for meaning and beauty in their work!
Two conversations this weekend make me think that there's a vibe shift afoot in Silicon Valley around what one should work on and what is worthwhile. Culturally, it feels like the moment is ripe for new frameworks: • Davos expert morality is stale and discredited. • It's also
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I was in awe the first time I heard about the idea of engineering living replacement grafts to cure disease and trauma. Doing so at scale can change the way we treat and prevent damage. The stakes are high and the problem is complex but our data show that it is tractable. We
polyphron.com
We are building a scalable tissue foundry. The platform will be able to engineer any human tissue of any size or complexity.
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Great piece - fully agree that scientific advances by themselves cannot make human trials unnecessary. While I don’t have (yet) a full view of how to make clinical trials more efficient, I strongly believe: 1) Development of new Tx and indication selection should go hand in hand
I & @JackScannell13 wrote a manifesto on reviving pharma productivity for @IFP. Public debates focus on improving science or loosening approval. We argue there's real leverage in optimizing the middle part of the drug discovery funnel: Clinical Trials. https://t.co/yZwzDVyWDy
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Watch this team. They will crush! 🥳
Human tissue, per gram, is one of the most valuable substances on earth. Engineering it at scale will allow us restore heathy function to organs and maximally extend life. Our early data shows it's tractable. Here's our vision for the company we are building:
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