🚨New preprint from the lab!🚨. We found a preference for visual objects in the mouse spatial navigation system and discovered that visual objects dynamically boost the encoding of head-direction!. 🧵👇1/.

RT @KatjaReinhard: Finally it's out! Thanks to Felix Baier, Karl Farrow and Hopi Hoekstra! And a big thank you to a….

RT @chr_mayer: Now out in #NatureNeuroscience: new paper from our lab — "Temporal control of progenitor competence shapes maturation in GAB….

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RT @TimGollisch: How natural stimuli lead to highly correlated ganglion cell activity in primate (marmoset) and mouse retina. Now out in @n….

RT @SantiagoRompani: The deadline to the 2nd Subcortical Sensory Circuits conference is now extended to the 30th! See here the amazing list….

Special thanks to our institutions and funders!! 🙏@MPIforBI @yourUMG @MBExC_de @mcgillu @snsf_ch @dfg_public. See also the thread of @apeyrache !! 🤩

In short, visual objects refine population-level HD coding, potentially helping the brain's internal ‘compass’ anchor to external cues.🧭 Whether this finding extends to other types of spatially tuned neurons throughout the spatial navigation system remains to be explored! 7/

At the population level, HD cells form a continuous ring attractor. HD cells on the ring coding for the visual object direction were boosted, while cells coding for other directions were suppressed by visual inputs. This held true both in head-fixed and freely-moving mice!⚡📡 6/

We then asked: How are visual object signals integrated with spatial signals? We teamed up with HD expert @AdrienPeyrache ✨ Mice were recorded freely-moving in an arena, then head-fixed for visual stimulation. Both PoSub HD cells and FS interneurons preferred objects! 5/

To our surprise, we found that spatial navigation regions responded stronger to objects! We replicated this finding in both anaesthetised and awake mice and confirmed fUS results using ephys. Postsubiculum, a main hub of the head-direction (HD) system, was the top hit!🎯 4/

This story started with a paradox: Mice 🐭 can see objects, but no regions specifically responding to objects like in primates have been found so far. Inspired by early human fMRI studies, we used an unbiased functional ultrasound (fUS) screen to look beyond the visual cortex. 3/

A 4-year team effort led by the brilliant @DomSiegenthaler 🚀, co-supervised by Stuart Trenholm 💫, and in collaboration with @AdrienPeyrache ✨! Huge thanks to our amazing co-authors @JohannaLuiseM , @hdennyNeuro , and @SSkromne!! 🙌 2/.

RT @OsamaHarraz: 📰Excited to share our latest work just published in @NatureComms . Endothelial Piezo1 channel mediates mechano-feedback co….