The Drakesmith Lab
@Drakesmith_Lab
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Welcome to the @UniofOxford iron lab! Based in the @MRC_WIMM @MRC_TIDU we research the involvement of iron in immunity and pathogenesis.
Oxford, England
Joined December 2018
Two new contributions from us: @MeganRTeh on the wild metabolism of CD8 T-cells in iron deficiency and why they love aspartate; and the current landscape of the strong influence of iron on immunity in general, with @JoeNFrost.
nature.com
Nature Reviews Immunology - Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates...
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Wonderful to see this out, a big effort led by @AE_Preston and fun for the lab to do something new (and very very old)
nature.com
Nature Communications - Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control...
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Getting tooled up with props for this! @World_of_Wade @OxUniEarthSci will bring his rocks.
Don't forget to book your tickets for IRONCLAD (14 October), a 4.6 billion-year whistle-stop tour of events covering the formation of our planetary home, the evolution of complex life, and iron’s role in driving infections and illnesses. Book here: Hal
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Looking forward to this @World_of_Wade ?.
Join Hal (@Drakesmith_Lab) and Jon Wade (@OxUniEarthSci) for a whistlestop tour spanning the formation of our planetary home to modern-day vaccines! 🌍💉.
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Looking forward to doing a thing with @World_of_Wade ! Watch out for meteorites.
IF Oxford – the science and ideas festival – returns in October 2024 💡. Pick from pioneering performances, hands-on experiments, interactive events and more. RDM is involved in three events this year! 🎉. Read more about our events 👇. #IFOxford2024
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RT @BloodJournal: Hemochromatosis C282Y homozygotes had an increased risk of any infection and a markedly increased risk of sepsis and deat….
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RT @yoncabulutmd: The iron curve: infection at both ends. Hypoferremia and hyperferremia were both associated with….
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Glad you enjoyed it @boronfan and great to have a botany guy in the house!.
I am struggling to summarise what was the best bit of #WIMMDay2024. As a plant-microbiologist now turned human nutritionist in @Drakesmith_Lab @MRC_WIMM, today I got:.
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Aw thank you @Susannajd - I suspect many folks have been very afraid. .
Everything you ever wanted to know about why cells need iron but were afraid to ask - beautiful review by @MeganRTeh @Drakesmith_Lab @AEArmitage1.
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Iron deficiency is highly prevalent worldwide but how it manifests at molecular/cellular levels is poorly understood. The brainchild of @MeganRTeh our new review is a compendium of why cells need iron and what happens when there isn’t enough!
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Delighted to host @DrAimeeLee today for an excellent seminar on her Long Covid work (with @MPMule and others) @MRC_TIDU in @MRC_WIMM, here with an added ironic photo-op
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A long time ago my first and formative research experience was with @HironoriFunabi1 in Kyoto. He was absolutely marvellous then and he still is today, in a London pub. And now he likes iron, a bit. Thank you Hiro!
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A bit of what we’re up to….
For this year's #DayofImmunology, we spoke to 3 of our scientists, @Drakesmith_Lab, Agne Antanaviciute & Jan Rehwinkel, to get a snapshot of some of the fantastic immunology research taking place in our Unit at the @MRC_WIMM . Watch the full video here:
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Love the figure in your Commentary @OrianaMarques5 !.
. as well as our take on it, here: @Mamu10439255.
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RT @MedCambridge: Published in @NatImmunol research finds that low iron levels resulting from infection could be key trigger of long COVID….
nature.com
Nature Immunology - Smith and colleagues find that a multivariate signature of unresolved inflammation and altered iron homeostasis detected beyond 2 weeks following acute COVID-19 onset was...
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Delighted to help out on this in-depth analysis of early drivers of Long-Covid, heroically led by @DrAimeeLee Iron is needed for so many biological activities, when it’s in the wrong place it can cause big problems- phenomenon may not be limited to SARS-CoV-2.
Ironing out long-COVID. the result of a mammoth, years-long collaborative effort between @Cambridge_Uni and @Drakesmith_Lab investigating the link between iron dysregulation during COVID-19 and long-COVID is out today in @NatImmunol Check it out!.
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Fully agree! Deeper understanding of causes and consequences, and multiple approaches to combatting anaemia are needed.
ASH President @Narla_ASH2024 reflects on ongoing ASH initiatives and shares his priorities for the Society, both nationally and globally:
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