
Rani Bansal, MD
@DrRaniBansal
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@DukeCancer breast oncologist, former Chief oncology fellow @brownUcancer #bcsm
Joined August 2021
Excited to discuss updates in breast cancer treatment! Join @RadiologyACR for the upcoming #AIRP Breast Imaging Course Nov. 7-8! Experience a virtual in-depth review of #breastimaging with a multidisciplinary team. Learn more and register today:
acr.org
Experience an in-depth review of breast imaging with a multidisciplinary team, providing a holistic approach to breast cancer treatment and management.
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DB-05 press release reporting significant improvement in IDFS with T-DXd vs. T-DM1 for residual HER-2 #bcsm after neoadjuvant therapy. Presentation in presidential session at #ESMO25. #myESMOAmbassadors
https://t.co/tdXUUIx5ng
astrazeneca.com
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Vitamin B12 for prophylaxis of capecitabine-associated hand–foot syndrome 💥Oral methylcobalamin reduced capecitabine-related HFS in HER2-negative early BC, with no added safety concerns 💬A simple prophylaxis option to support treatment adherence https://t.co/khCOH0RDv7
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New in @NatureMedicine's News & Views: A HER3-targeting antibody-drug conjugate for leptomeningeal metastasis. Check out the invited commentary on the phase 2 TUXEDO-3 trial by Carey Anders, MD, @DrRaniBansal, & @DrVanSwearingen
https://t.co/3LGXnIQZzV
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We need to keep pushing the field forward for better options for our patients with LMD! @CareyAnders1 @DrVanSwearingen
@DukeMets @DukeCancer
https://t.co/7R2InqsBGd
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Recent rationale in metastatic breast cancer for bringing ADCs into the 1st line has quoted very high 1st line attrition rates of patients not making it to second line. This study is likely more accurate of 2025 patients. In total, 9% of patients with MBC do not make it to
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After recurrence, the median duration of first-line metastatic treatment was 3.0 months (IQR 1.6-5.0 months)…we need to identify best systemic therapy options for those recurring on adjuvant CDK4/6i!
Pleased to share the first series of pts who experienced recurrence on adjuvant abemaciclib+ET: ➤ 9.2% (15/163) recurred ➤ 50% ER loss post-tx ➤ 90% TP53-pathway alterations post-tx ➤ Median 1L m+ tx duration: 3.0 mo (IQR 1.6–5.0) https://t.co/5Jpzq8uyc2
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Oral abstract early #BreastCancer session at #ASCO25: do we really need #carboplatin with neoadjuvant #taxane #trastuzumab #pertuzumab in #HER2+ disease? Very promising findings but survival outcomes are needed @OncoAlert @ASCO #bcsm
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Very exciting!!! We need new drugs especially in mTNBC and especially post topo-1 ADCs as they move further up in our treatment paradigm
Particularly excited about the activity in #TNBC post topo-1 ADCs. 86% had seen savituzumab govitecan, 1/3 had seen T-DXd, 1/4 had seen both! #ASCO25 #ADC #NewTargetNewPayload
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Agree! Also if we think in real world for our pts - maintenance HP (esp now we have a subq option) allow pts to not need a port, less frequent labs, less time spent in infusion, more time outside of cancer center Looking forward to hearing pt perspectives! @GRASPtweets @ASCO
Indefinite T-DXd in 1L when patients could otherwise consider maintenance therapies and a chemo free interval is a hard sale. Great review of limitations and needed biomarkers, ongoing trials and overall intention in this patient population by @claudine_isaacs .
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DB-09 📣by @stolaney1 TDxd + P vs THP Great review by Dr. Isaacs of results we need QOL data especially for pts on maintenance HP vs TDxd, we know clinically that there is MUCH more tox w/ TDxd & many pts experience great QOL on HP maintenance therapy @ASCO #bcsm
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1000% agree - @AngieDemichele broke down each point so well and gave great insights on how we should think about this data and its potential limitations in clinical practice right now @ASCO #bcsm
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Key point! Intensive ctDNA screening for every patient when only 10% were eligible to switch? Interested to see the data and discussion later today @ASCO
#bcsm
1. Intensive ctDNA screening of 10 patients to find 1 who might qualify for 'switching' based on ESR1mut. Worthwhile? 2. Does switching among asymptomatic patients with no radiological progression make sense when drug could be added later at progression?
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Feeling incredibly grateful to be joining this amazing group of breast oncology colleagues at Duke this fall! 💙#ASCO25
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Our Duke breast onc family at ASCO ❤️ @ASCO @DukeCancer
@HeatherMoore16 @CareyAnders1 @marijasullivan
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