Gopal Iyer
@DrGopalIyer
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Professor, Head and Neck Surgeon, Clinician-scientist, budding immunologist, trainee architect. Views expressed are my own & not reflective of my affiliations.
Singapore
Joined May 2021
During which time we could show effective response to vaccines (Covid mRNA) and tumor dissociates which was really amazing… another major tool to study the tumor-immune axis!!!! @EngEongOoi @DrNarayanaSub Another great collaboration between #nccs and @NUSingapore
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https://t.co/YcB4AvSx6O Using our previous system for tumor explant cultures PhaseX, we were able to sustain lymph nodes the smoking gun of the immune system for 7-10 days! @elizafongls @drbruceashford @DrMLChua @duvvuri_md @rbryanbell
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AS01-adjuvanted vaccine alters baseline correlates of T cell response ...
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Thankful that my group's work is featured in The Straits Times! https://t.co/21gUaU3K9r Check out: https://t.co/w1VEPZ0p6M
@BME_NUS @NUSingapore @AdvPortfolio
advanced.onlinelibrary.wiley.com
This study presents a hyaluronan-based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient-derived explants from peritoneal metasta...
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🔑KEYNOTE-689 Update at #AACR25 new standard? 🌟Neoadjuvant + adjuvant #pembrolizumab in LA-HNSCC 🌟 EFS HR: 0.73 (95% CI 0.58–0.92) 🌟2-yr EFS: 75% vs 62% 🌟CPS ≥10: HR 0.66 (95% CI 0.49–0.88) ❎OS pending—new standard? ARTICLE: https://t.co/dI5HxcolNY YouTube:
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Nothing like hanging with friends from half way across the world, enjoying simple pleasures.. Walter Lee from duke… @kaisinyee @duvvuri_md @drbruceashford
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Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial - The Lancet Gastroenterology & Hepatology https://t.co/rPSYhiMTfR Amazing work led by my colleagues!!
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Our 2nd work supporting chromatin-related adaptation for acquired #Radioresistance in #HeadNeckCancer ! Collab with @echow310 & talented PhD student Sharon_Chan using QPOP that serendipitously showed Panobinostat efficacy against RR HNC Mechanistic work identified HDAC6 as the
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Great review on gamma-delta T cells for cell therapy by my hardworking PhD student Weikiang Lim !! Thanks to @esmo_iotech and @HaanenJohn
https://t.co/Idke8rI6Ri
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Amazing meeting in Bali! A tour de force of intent by the Indonesia to drive cancer prevention and treatment for the next decade!!! #iicc @RebeccaDSing
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Shockingly accurate and universal!!!!! @drbruceashford
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Exosomes making headlines… who would have ever thought!!! @drbruceashford @VinPaleri @DrNarayanaSub @duvvuri_md
straitstimes.com
Introducing a protein into a patient's bloodstream can make the cancer respond to an affordable lung cancer drug. Read more at straitstimes.com. Read more at straitstimes.com.
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Fundraising for cancer research and care!!! @danieltanmd @DrMLChua @elizafongls @ChiaClaramae @Valeriechew29
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Single protein makes the difference for this potential EV-based therapeutic #notvoodoo @ElizSMcKenna 🤣🤣🤣
It’s finally out…exosomes as a potential cancer therapeutic due to the presence of a single protein EGFR Isoform D… took us to realm of splicing, exosomes, endosomal signaling and more recently manufacturing….who knew!!! https://t.co/NJ8Bd06YGk A brief summary:
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Potential (we hope) a whole new therapeutic pathway to convert EGFRG dependent cancer to EGFR druggable cancers!
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