Dec Manning
@DecManning94
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I’m a postdoc at UC Davis researching mechanisms of blood flow control in the brain and heart
Davis, CA
Joined December 2012
This is an important concept, and not just in the heart. Microvascular supply is crucial and can get disrupted in all tissues, in many ways. We want to understand why it happens, how, and most importantly. how can it be prevented?.(5/5).
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The fact that these events occur so easily (28-day low-dose AngII infusion) says volumes about the delicate metabolic balance our vital organs maintain to function. We're living on the edge! .(4/5).
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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The SA node develops bradycardia, arrhythmia, oxidative stress, hypoxia, and failed angiogenic signaling. These are crucial indicators of SA node dysfunction which could precede HFpEF and other cardiovascular disease. (3/5).
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Regionalized rarefaction affects the region of the SA node where the pacemaker activity is strongest and metabolic supply is the most important. The cells most at need are the most greatly impacted. (2/5).
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Our latest paper is out! @JACCJournals @ucd_physiology . We've shown that microvessels are lost in one specific region of the SA node in a model of early heart failure. (1/5)
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RT @HAT_Pritchard: Are you interested in discovering how blood flow to the brain is controlled and how it goes wrong in dementia? We have a….
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RT @HAT_Pritchard: Our study into the mechanism behind the reduced blood flow in dementia has been short listed for research story of the y….
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This review with @lfsantana68 and Ernesto Rivera focuses on what we know about capillaries as they grow, reach functional maturity, and degenerate in a range of diseases.
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Explore the mechanisms controlling microvessel growth, function and death in our latest review!. “The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies”.
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RT @CollinMatsumoto: Excited to share my newest work with the Santana Lab (@lfsantana68) published in @CommsBio! He….
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. and here it is! An exciting unveiling for Chisel-1, a functionalized nanobody which drives inhibition and internalization of CaVbeta1-associated calcium channels.
nature.com
Nature Communications - Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels...
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I have published a review!. My doctoral work focused on store-operated channels and the numerous ways they control skin function. Watch this space for data from my PhD @LivUniISMIB and new publications from my work with @lfsantana68 at @ucd_physiology.
frontiersin.org
The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydrat...
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