It was great to talk at #NHAD21 @VIBLifeSciences🧠 My unforgettable first time on a live conference stage!!

@nfattorelli from the @DeStrooperLab takes the stage as the first selected speaker this morning to explain how to study human disease by transplanting iPSC-derived microglia into mouse brains. #NHAD21

Today is #WorldAlzheimersDay. Since VIB's inception, we've been working to better understand and treat this disease affecting millions across the globe. Explore how we continue to unravel the mysteries of Alzheimer's disease. #originofimpact #25yVIB 👉 https://t.co/mDjUyLqxXd

In our series of firsts-since-covid: today we are hosting our *first* Methusalem lecture of 2021! Please join us at 11 AM for Liqun Luo's talk on the wiring specificity of neural circuits. More info: https://t.co/6p0m91w9Ac @Stanford

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets. New review by Annerieke Sierksma, Valentina Escott-Price @UKDRI and @BStrooper @DeStrooperLab out in @ScienceMagazine today! https://t.co/FuWXjS5U8h

Congrats to @MancusoRenzo!

"LifeTime has brought together scientists across fields – from biologists, to clinicians, data scientists, engineers, mathematicians, and physicists – to enable a much improved understanding of molecular mechanisms driving health and disease."

I am super stoked 🥳 to have been part of this awesome work from Weit-ting Chen (first) and Bart de Strooper (last) and many others. It just come out, folks, check it out. 😍

@BioImagingCore @CARTANAbio @scilifelab @riken_en 9/ Further work is needed to understand whether, and when, removal of amyloid plaques—for instance by antibody therapy—would be sufficient to reverse these ongoing cellular processes.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 8/ Our data demonstrate that amyloid plaques are not innocent bystanders of the disease, as has been sometimes suggested, but in fact induce a strong and coordinated response of all surrounding cell types.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 7/ Many of the identified genes show similar alterations in human brain samples.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 6/ A second network, enriched for genes involved in myelination and mainly expressed by oligodendrocytes, is activated under mild amyloid stress but becomes depleted in microenvironments with high amyloid accumulation.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 5/ In AppNL-G-F mice, plaque-induced genes gradually co-express upon increasing Aβ load and encompass complement, endosomes and lysosomes, oxidation-reduction, and inflammation.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 4/ We were able to characterize two gene co-expression networks that appear to be highly responsive to Aβ deposition.

@BioImagingCore @CARTANAbio @scilifelab @riken_en 3/ We complemented this approach with an orthogonal in situ sequencing method that visualizes hundreds of selected transcripts with cellular resolution. We integrated all of the information into a fully accessible database https://t.co/XwCNr0bIdW

@BioImagingCore @CARTANAbio @scilifelab @riken_en 2/ A central question in AD research is the relationship of amyloid plaques to the neurodegenerative process. We used spatial transcriptomics to measure, in situ in hundreds of small tissue domains, genome-wide transcriptomics changes induced by amyloid plaques.

1/ Really happy to see this story out online! Kudos to the entire team: Wei-Ting Chen, Ashley Lu, Mark Fiers and many others involved, including @BioImagingCore @cartanabio @scilifelab @riken_en

We are looking for a postdoc to use spatial transcriptomics, in situ sequencing, and multiplexed proteomics to untangle the cellular response to #amyloid plaques and tangles in brains affected by or resilient to #Alzheimer’s disease. https://t.co/kA7xobo5pE

New preprint out De Strooper lab at @CBD_VIB with @VE_ZSU from our lab on how impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement #alzheimersdisease

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology. Latest findings of the @DeStrooperLab now out in (and on the cover of) @EmboMolMed. Congrats to the entire team! https://t.co/AG17gjpYfJ