David Lalaouna
@DavidLalaouna
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Permanent CNRS researcher CRCN @cnrs @unistra https://t.co/kzKWJdhWIi
Strasbourg
Joined July 2018
The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus | mBio
journals.asm.org
Staphylococcus aureus causes numerous and varied infections in mammals, making it a significant public health burden and concern. The prevalence of S. aureus infections is due to its robust reperto...
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W1TTW2 Professorship in Biology of Microorganisms (m/f/d) | Ruhr-Universität Bochum | 4864
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A huge thank you to all our collaborators ! 🙏 @MarchandVirgin3 @jaitreeau @WaldronLab @jydutheil Jeffrey Boyd and Thomas Kehl-Fie, who are not on X.
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3/3 ZinS emerged via horizontal gene transfer of the zinP mRNA and neofunctionalization of its 3' UTR 🔄
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2/3 ZinS is a dual-function sRNA encoding a small peptide, ZinP
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1/3 We have revealed ZinS as the first small regulatory RNA involved in a zinc-sparing response in bacteria. ZinS (formerly RsaX20) negatively regulates Zn-dependent enzymes, including alcohol dehydrogenase to spare this essential element for S. aureus survival and virulence.
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🚨 New Preprint Alert 🚨 Our latest work, A Zur-dependent regulatory RNA involved in maintaining zinc homeostasis in Staphylococcus aureus, is now live on bioRxiv! 🧬🦠📄 Check it out here: https://t.co/RnTBzhdEME
biorxiv.org
Small regulatory RNAs (sRNAs) are key drivers of bacterial adaptation to environmental fluctuations, including iron and manganese restriction imposed by the host. This study explored the repertoire...
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New review out in @NAR_Open! 🔎 What makes a bacterial small RNA work? We discuss: 🧬 Sequence features 🤝 Hfq, ProQ & RNA chaperones ✂️ RNase E & degradosome interactions 🧪 Lessons for synthetic RNA design 📖Read: https://t.co/I7kWwFVa9c With @jaitreeau @UNSWBABS @DavidLalaouna
academic.oup.com
Abstract. Bacterial small RNAs (sRNAs) are key regulators of gene expression, interacting with target messenger RNAs (mRNAs) through imperfect base pairing
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Finally, we're recruiting! If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: https://t.co/RoxLVkd9IE
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Register today and join us in Strasbourg! 8th Conference on Regulating with RNA in Bacteria and Archaea September 1 - 4, 2025 - Strasbourg Convention Centre Take advantage of the early bird discounted rates and REGISTER by June 1 https://t.co/0UNKJo3L1p
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🎉 The MCAA turns 11! 🎉 Since its founding in 2014, the MCAA has grown into a vibrant global network of over 22,000 members spanning 155 countries, 37 geographical Chapters, and 11 thematic Working Groups. 🌍 Read more 🧵
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Looking for a postdoc position? Want to apply your biochemistry skills to answer evolutionary questions of how metalloenzymes evolve? Join my growing team in Warsaw at @IBBPAS. We're seeking a talented new postdoc to work on the superoxide dismutases. https://t.co/blroyAIrs0
We are recruiting for my lab in Warsaw. One postdoc position available for a biochemistry project on superoxide dismutases (of course). https://t.co/blroyAIZhy We're also looking for a technician. https://t.co/PNXMQdPlcH Get your application in!
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I have a PhD position available in my group, starting March 2025. If you have an interest in biochemistry and would like to study an exciting class of copper proteins (aka weird Cu tubes) from bacteria, I'd love to hear from you. You should apply here: https://t.co/kswIkoKBm7
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Apply now, spread the word: three (3) fully funded Helmholtz research groups (assistant prof level) with attractive packages. Topics: RNA-based medicine, microbial RNA, and RNA-based infection research incl. RNA technologies. Great environment for young people. Come and join us.
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Latest arricle out from @JeffMBoyd1 that we collaborated with along with @CarrollMicroLab @BoseMicroLab @EricSkaar. Showing that a non-coding RNA in S.aureus can impact metabolism and virulence! @Rutgers_NJMS @RutgersU
https://t.co/JtZDEY2TBe
academic.oup.com
Abstract. Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in host tissues. Staphylococcus aureus uses the ferric uptak
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For those studying metals in biology, I encourage you to join this seminar series. Diverse international speakers covering a range of topics in the field. Seminars are recorded, so the archive can be viewed at a later date - ideal for student training!
cassyni.com
Thanks to the Cassyni platform and Springer, the webinars will be recorded (if accepted by the authors) and a DOI will be assigned to the recording presentation. The recorded webinars will be after...
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Are you interested in exploring how RNA modifications influence gene expression in bacteria? My lab invites applications for a fully-funded PostDoc position at Jena University. For details, please visit: https://t.co/XwmHMwZohR
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Looking for postdoc candidate, who is interested in RNA-protein interactions, RNA localization and gene regulation. Candidates with backgrounds in biophysics (particularly single-molecule imaging), chemical biology and cell biology are all welcome to apply! Please help retweet 🙏
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A DFG-funded Phd position for 3 years to study gene regulation in cyanophages is available at Cyanolab in beautiful Freiburg/Germany from Jan 2025. Please re-tweet, details here:
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I'm happy to share the fruit of a long labour. Many thanks to all co-authors! @GabyGonzE @jensRNA @marteyn_lab @LabRomby
https://t.co/bkrIhcw2N1
biorxiv.org
Maintaining manganese and iron homeostasis is critical for the human pathogen Staphylococcus aureus . To counteract metal-based host defense strategies (e.g., nutritional immunity, metal poisoning),...
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