Saleh Alquethamy
@SalehAlquethamy
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Postdoctoral fellow at @UNSW. Opinions are my own.
Sydney, New South Wales
Joined January 2012
New review out in @NAR_Open! 🔎 What makes a bacterial small RNA work? We discuss: 🧬 Sequence features 🤝 Hfq, ProQ & RNA chaperones ✂️ RNase E & degradosome interactions 🧪 Lessons for synthetic RNA design 📖Read: https://t.co/I7kWwFVa9c With @jaitreeau @UNSWBABS @DavidLalaouna
academic.oup.com
Abstract. Bacterial small RNAs (sRNAs) are key regulators of gene expression, interacting with target messenger RNAs (mRNAs) through imperfect base pairing
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How does the pathogenic #bacteria Haemophilus influenzae scavenge the crucial #biometal #manganese? New work from @McDevitt_Lab @KapplerUlrike @Kobe_Lab_ @DeplazesEvelyne reveals the role of HfeA and its ABC transporter in metal scavenging and virulence. https://t.co/KPdKbDpRe7
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Congratulations to Dr @SalehAlquethamy on completing his Doctor of Philosophy requirements at @UniMelbMDHS. A hugely talented #bacteriology #biochemistry scientist now working in the @EijkelkampLab under the mentorship and leadership of the exceptional @BEijkelkamp 🦠🧫🎓🍾🥹
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Congratulations to @SalehAlquethamy from the @camcdevitt lab on his latest paper coming out of his PhD. #phdlife The paper combines #biochem, #crystallography, #compchem MD simulations and #Bioinformatics to study the Zn-binding protein ZnuA in A. baumannii.
The last publication out of my PhD is out! Please check out our latest work examining the structural/biochemical properties of A. baumannii Zn recruiting protein ZnuA. Many thanks to @camcdevitt Bostjan Kobe @DeplazesEvelyne @MDaviesLab and many others!
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**ONLINE NOW!** @hbernstein16 and I are delighted that our paper using Cryo-EM and in vivo assays to understand outer membrane protein folding has found a home at Cell! @CellCellPress Here is a free access link to the article: https://t.co/hAsd8KIlhQ 1/3 https://t.co/DSKQfHyU2h
cell.com
The folding of the β barrel protein EspP by the β barrel assembly machinery in E. coli involves the progressive conversion of a β sheet into a barrel-like structure in a process that is influenced by...
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The last publication out of my PhD is out! Please check out our latest work examining the structural/biochemical properties of A. baumannii Zn recruiting protein ZnuA. Many thanks to @camcdevitt Bostjan Kobe @DeplazesEvelyne @MDaviesLab and many others!
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Some handy TraDIS analyses by @flamycain @PaulsenLab in combination with elegant metal biology work by @SalehAlquethamy @AdamsFelise @McDevitt_Lab @RCID20 @BRaTlab reveals @A_baumannii's environmental roots when exposed to cadmium stress. https://t.co/YaXOHEdn0D
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Congratulations to @SalehAlquethamy @AdamsFelise and Ram Maharjan for their study of #cadmium resistance in Acinetobacter baumannii. A great collaboration led by @BEijkelkamp with @flamycain @PaulsenLab @BRaTlab @RCID20 @McDevitt_Lab @TheDohertyInst
https://t.co/TzbtZwWATQ
journals.asm.org
Cadmium toxicity is a widespread problem, yet the interaction of this heavy metal with biological systems is poorly understood. Some microbes have evolved traits to proactively counteract cadmium...
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🥲 So happy to finally share my first, first-author paper, on zinc uptake in S. pneumoniae via AdcAII. https://t.co/QgCmxtgY0U Huge thanks to all those involved, especially my supervisor @camcdevitt, our amazing collaborators at @UQ_SCMB & @DeplazesEvelyne, and the @McDevitt_Lab!
frontiersin.org
Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization and infection. This is achieved by the ATP-binding cassette transpor...
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The structural basis of manganese import by the pneumococcal ABC importer PsaBCA. A great collaboration by @StephieNeville @DrMJMaher @megan_omara_ANU @MDaviesLab @HugoMacdermott @StephenFairwea8 @Bio21Institute @TheDohertyInst @UniMelbMDHS and So Iwata.
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40 scientists and physicians gathered together in Germany with the support of the Strungmann Forum to discuss the impact of trace metals on infection. The resulting discussions were compiled in a book that is now available on NCBI. Enjoy and share!
ncbi.nlm.nih.gov
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It was great fun having @katelambe_ from #9news to talk superbugs @Flinders. Also love the bacterial membrane simulation from @megan_omara_ANU and @HugoMacdermott. Check https://t.co/PuAS98nmdZ for more info.
eijkelkamplab.com
South Australian scientists have discovered a new weapon that's easily accessible to fight superbugs. @katelambe_ #9News
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The first paper from my lab at Macquarie @MQMolSci is out in preprint!! In collaboration with @EijkelkampLab @PaulsenLab @DrFranShort @LBarquist @CamVetSchool we used #TraDIS to examine copper and zinc stress in #acinetobacter & uncovered regulator DksA https://t.co/mlvvVKjgXT
researchsquare.com
Bacterial coordination of stress resistance mechanisms in harsh environments is key to long-term survival and evolutionary success. In many Gram-negative pathogens, both general- and specific-stress...
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It was an honour to co-author this fantastic review article in @ACSChemRev with an amazing bunch of researchers... @BRaTlab and @PaulsenLab
It was a pleasure to work with some of the legends and emerging leaders in bacterial membrane transport on this very comprehensive review paper in @ACSChemRev @PaulsenLab @BEijkelkamp
https://t.co/OOdNQ3aZ8G
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Very excited to be participating in this initiative in the @McDevitt_Lab @TheDohertyInst @unimelb and with Trevor Moraes #UofT. If you're interested in a PhD studying #bacteria #microbiology #pathogens and #Zinc #metalsinbiology see below for details.
#UofT is excited to approve 12 joint #PhD projects with @unimelb. These #Toronto-#Melbourne #researchandtraining clusters span all major disciplines. Read more here: https://t.co/OuPFKw8mnC.
@UofTSGS @UofTArtSci @uoftengineering @uoftmedicine @UofT_dlsph #Globalpartnerships
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How does cadmium intoxication affect the pneumococcus? Latest #metalsinbiology work by @StephieNeville @McDevitt_Lab and colleagues @BEijkelkamp Paton, Roberts and Rosch reveal mismetallation of essential pathways and the coping strategies to survive. https://t.co/tTyAboYEkG
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AcinetoVibes2020, an international FREE conference on Acinetobacter is next week (May 7-8). More than 200 attendees already registered and 14 labs will present. You can still register at: https://t.co/SeJAJGyOTc
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Here’s our latest Coxiella story … a huge amount of work and perseverance by @33ecirtap and a great team of collaborators @TheDohertyInst, across the globe @YaleMicroPath and across the road @VCFGconnect
pnas.org
Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB secretion system...
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@TheDohertyInst end of year party. The theme is heroes vs villians... @SalehAlquethamy and I came as academic spam emails and reviewer #2 (villians of course!?)
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