A new RCSI study in @NatureComms reveals how blocking HDAC6 alters metabolism in cancer cells. It also shows a new role for HDAC6 in regulating cells' energy pathways, making it a potential target for tumour metabolism. Read the paper ➡️ https://t.co/Jg2MoBFKJj #RCSIdiscover

Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: @DrCDowling @IngmarSchoen @emmamarykerr @marie_mcilroy Read it here: https://t.co/dV8mEP7PbV 🙏 @Researchirel For Funding.

This review dives into the impact of zinc binding group diversity in HDAC inhibitors—shaping potency, selectivity, and therapeutic potential.

Delighted to contribute in this recent review on HDAC inhibitors. Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups https://t.co/bRKZGy83nR #mdpipharmaceuticals via @Pharmaceut_MDPI

This study highlights how methylation can drive substantial changes in molecular behavior, with direct implications for bioactivity and drug design involving the NAH motif.

By combining DFT calculations, NMR spectroscopy, PXRD, NBO, and NCI analyses, we observed significant conformational changes, particularly a shift from anti to syn arrangements and disrupted conjugation in dimethylated systems.

Delighed to see this work finally published. Exploring the Conformational Effects of N- and C-Methylation of N-Acylhydrazones | ACS Omega https://t.co/6dJXiNTnA7 We explored how N- and C-methylation affects the conformation and electronic properties of N-acylhydrazones.

Thrilled to have hosted Mandy Daly @IrishNeonatal today for an incredible talk on PPI (Patient and Public Involvement) for our RCSI MPharm year 2 students. Huge thank you to Mandy for such an inspiring session showing the importance of engaging patients in decision-making ! #PPI

Such an inspiring lecture! It was great to have Colin Ryan delivering a guest lecture on drugs in sports for our RCSI MPharm Year 2 students.

A wonderful start to the 1st session of the IAP 2024 conference hosted by the School of Pharmacy and Biomolecular Sciences, RCSI. Experts from across Ireland & UK, coming together to enhance the impact of pharmacological science on healthcare and patient outcomes. 🗣️💊🔬

We are 7 days out from the return of our #PBSResearch Seminar Series for the new academic year, supported by @thermofisher. Kicking off 2024/25 we have talks from @SteveWKerrigan & @ClaudineDuggan. Join us in the Albert Lecture Theatre at 3pm next Tuesday. #RCSIDiscover

Job alert📢Fantastic opportunities for a talented & motivated Lecturer in Pharmacy Practice https://t.co/HywyUNXpud and a Teacher Assistant role https://t.co/58EVr9YhDd to join us @RCSIPharmBioMol Apply by 22nd September➡️ #RCSIeducation #jobfairy RTs & Shares appreciated!

Our BSc in Advanced Therapeutic Technologies (ATT) from @RCSIPharmBioMol goes beyond a basic science undergraduate degree to give students the skills needed to become science innovators. Learn more in today's @IrishTimes 🔗 https://t.co/h7k6m6zvn8 #RSCIeducate

We look forward to our next PBS Research Seminar taking place next Wednesday 8th Nov 3-4pm with two exciting talks from @MMResearchIRE and our PBS Athena Swan Champions @ChiaraDeSanti3 & @IngmarSchoen. Cookies and tea/coffee from 2.30pm🍪☕️Kindly sponsored by @thermofisher

Take a look at ‘First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins’ 🔓 New from @DGriffithGroup and co. https://t.co/hEPqGz5FXx https://t.co/hEPqGz5FXx

We invite you to join us @RCSI_Irl for next week's #PBSSeminarSeries event on Wed 18 October @3pm to hear valuable research updates from @DanielAlencar_R & Ashwini Shanmugam. Kindly sponsored by @ThermoFisher 🥼🧪 See ⬇️ for further information! #RCSIDiscover #PBSResearch

Delighted “First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins” is published as an advanced @ChemCommun article. Congrats @PaulODowd10 & many thanks to @NiTriona for valued collaboration @ChemistryRCSI @SSPCentre https://t.co/WSy2ICmgwm

Pleased to share our preprint  "First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins" is posted on ChemRxiv. Exciting ongoing collaboration with @NiTriona and team. @RCSI_Irl https://t.co/a5a3lXRDLV

Great work @MMResearchIRE @DanielAlencar_R 🚵‍♀️🚵‍♀️ @IrishCancerSoc ‘On Y’er Bikes for cancer’ research 🔬 👨🏽‍🔬👩🏻‍🔬

I am delighted to see my first senior author paper published in JTO. HDAC6 inhibition exploited a therapeutic window in KL NSCLC nominating a novel strategy for the treatment of KRAS-mutant NSCLC with co-occurring LKB1 mutation @MedicineAtUL @HRI_UL @UL https://t.co/HZjtGlk5yL