Curt D. Sigmund, PhD
@CurtSigmund
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***My views are mine, and no one else..*** Believe in science.
Milwaukee, WI
Joined July 2012
Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice | Hypertension
ahajournals.org
BACKGROUND: Selective ablation of CUL3 (Cullin-3) in vascular smooth muscle cell-selective CUL3 knockout (S-CUL3KO) results in severe hypertension with paradoxically unaltered ANG II (angiotensin II)...
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No pressure—but if the renal baroreceptor machinery piques your curiosity... @curtsigmund & team @MedicalCollege reveal mice lacking CUL3 in vascular smooth muscle cells exhibit robust hypertension with paradoxically unaltered renin expression and decreased integrin β1
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Cullin-3 regulates the renal baroreceptor machinery that controls renin gene expression
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There is renin in the brain!!!!!! Great job team from @MCWPhysiology. Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus | Hypertension
ahajournals.org
BACKGROUND: The importance of the brain renin-angiotensin system in cardiovascular function is well accepted. However, not knowing the precise source of renin in the brain has been a limitation...
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Sigmund, Grobe, Nakagawa lab dinner at AHA Hypertension Scientific Sessions 2024 in Chicago. @MCWPhysiology @JLGrobe @NakagawaPablo
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Time for @MayorMKE to step in and save July 3 fireworks. Be the hero…..Our increased tax dollars at work. #MKEFireworks.
Milwaukee's July 3rd lakefront fireworks canceled, here are some alternative celebration locations https://t.co/WsqGczdfzI
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Congratulations to @MCWPhysiology student Alisha Ziegler and mentor @JLGrobe on being hooded at the @mcwgradschool hooding ceremony yesterday.
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Congratulations to @nmathieu29 on publication of her thesis research. Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. https://t.co/7wjDSfsBh7
@MCWPhysiology @CurtSigmund
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Congratulations to @nmathieu29 Natalia Mathieu, a graduating @MCWPhysiology PhD student for winning the best predoc presentation of the Water and Electrolyte Section at #APS2024.
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Excited to start my second 5-year term as the James J. Smith & Catherine Welsch Smith Chair of Physiology at @MedicalCollege. Excited to work with the exceptional faculty, staff and trainees in @MCWPhysiology. Stay tuned for announcements for recruiting faculty. @CVCatMCW
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How do you appropriately credit a person whose contribution to a scientific study was the original idea?
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New research from the @MCWPhysiology and MCW Ob/Gyn collaboration. @CVCatMCW.
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Standing ovations to Dr. Chris Wilcox, the recipient of @CouncilonHTN Distinguished Achievement Award!!!
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