CreekLab
@CreekLab
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The Creek laboratory at Monash Institute of Pharmaceutical Sciences uses advanced metabolomics and systems pharmacology to investigate drug action in pathogens
Melbourne, Victoria
Joined February 2016
The latest paper from our lab identified extracellular metabolites of Pseudomonas aeruginosa correlated with ceftolozane/tazobactam-resistant subpopulations and modelled the time-courses of these metabolites @JessTait_PKPD @CreekLab @CRE_RESPOND
https://t.co/N5Kq29YHpi
journals.asm.org
Antibiotic resistance is a serious threat to global health and a particular burden for vulnerable patient populations such as those with cystic fibrosis (CF) or the critically ill (1). The optimiza...
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Call for Abstracts for Metabolomics 2024! Complete details online: https://t.co/NZwcbSKP8v Deadline for oral abstracts is March 7. #metabolomics
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@CreekLab & MIPS team introduces Orbitrap Astral MS for faster throughput, higher sensitivity, & deeper proteome coverage. Supported by a $3m grant from the Medical Research Future Fund, the platform fosters collabs among institutions & industry partners. https://t.co/ns66Eoye55
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We got our baby boy (Orbitrap Astral) @CreekLab, the entire @thermofisher team is at @MIPS_Australia. Can't wait to analyse samples @Monash_MPMF. Open to nickname suggestions.
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Couldn't be prouder of @Nathan_NguyenTN accomplishment, congratulations to my first PhD graduate. @NikVeldhuis @MIPS_Australia
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I'm super excited to share the results of our phase 2 randomised clinical trial using gut microbial metabolites to lower #bloodpressure, for now as a pre-print @VicHeartInst @MonashBiol @Monash_Science @MonashUni Funded by @heartfoundation @nhmrc A 🧵 https://t.co/wlkUZmMl3X
medrxiv.org
Background Fibres remain undigested until they reach the colon, where some are fermented by gut microbiota, producing metabolites called short-chain fatty acids (SCFAs). SCFAs lower blood pressure...
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Congratulations Doctor @MatthewChallis8 on graduation today. The end of a great chapter and the start of a successful career! @MIPS_Australia
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Very proud of Stanley Xie who was awarded a University of Melbourne Award for Excellence in Mid-Career Research Achievements.
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Nice review of omics-based drug target identification methods for malaria drugs published by @MatthewChallis8 @MIPS_Australia
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Great to see a full house @MIPS_Australia for the #viin_yis watching the next generation of @The_VIIN infection & immunity research stars #Globalhealth_TPA
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Just published - ex vivo evaluation of 12 repurposed drugs for COVID https://t.co/nUIBpevkOS Nature Portfolio's highlight https://t.co/JLAWu1uOdX of our paper on repurposing method https://t.co/1YRQTY4bmD Thank you to great team, including @ssvasan @CreekLab @CarlkRx
lnkd.in
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New work ranking top repurposed drugs for COVID Led by @ssvasan
@CreekLab
@CarlkRx Chris MacRaild, Ian Styles, Amanda Peterson @MIPS_Australia Faheem, Muzaffar, Murugesh @bitspilaniindia Anu Kumar, Alex McAuley @CSIRO Enzo Palombo @Swinburne Thanks @Sue_Dunlevy
@MonashUni’s @NatalieTrevaski & Darren in @Sue_Dunlevy’s national @newscomauHQ coverage of our #CovidIsntOver work https://t.co/SZXf6PLqZa “Although we haven’t quite said X marks the spot, we’ve narrowed down the search area to top 200 or so candidates” https://t.co/L68WEeEedk
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Honoured to be awarded @arc_gov_au future fellowship #FT22 to study malaria parasite metabolism!!! This is only possible thanks to my amazing team and many collaborators. @MIPS_Australia #GlobalHealthTPA
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Get ready for our Mid-Year Symposium!! Focusing on all things #multiomics and held at @Bio21Institute with some fantastic speakers. Its free AND hybrid, so you really don't have an excuse not to come. Register now at https://t.co/l0GJDJsEqt!
#proteomics #metabolomics #lipidomics
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#ASP2022 @G__Siddiqui from @CreekLab just gave an excellent talk about their synthetic ozonides target ID chemoproteomics pulldown and how the drugs perturbed parasite redox homeostasis!
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Agreed. Well done to Stanley, @LeannTilley and the whole team. Glad to contribute our 2c on metabolite ID, but happier to see how industry and academia can work together to discover new malaria drugs (with a cool mode of action)
Fantastic to see this work identifying a new antimalarial strategy published. Proud and privileged to lead the structural biology with a global team headed up by Prof. @LeannTilley. Congratulations to all involved! @UniMelb @Bio21Institute @TakedaPharma
https://t.co/zCgAphcztc
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MIPS #GlobalHealthTPA will be hosting a symposium & networking event this Friday at @MonashPharm on "Repurposing Medicines for #GlobalHealth". Registration essential https://t.co/3tEBjxneMr
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Excited to share our story on glutaminase inhibition in #KRAS-mutant #lungcancer - out today in @Cell_Metabolism! This couldn't have been possible without @sarahannbest & collaborators from @WEHI_research @AgiosPharma @TheDohertyInst @MonashPharm 👇👇
New! Glutaminase inhibition impairs CD8 TÂ cell activation in STK11-/Lkb1-deficient lung cancer
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Excited to share my research on #lungcancer #metabolism - online today in @Cell_Metabolism
https://t.co/EWY37WhgGJ Here’s the gist 🧵1/5 @CellPressNews @Sutherland_Lab @WEHI_research #OpenAccess #cancer #immunology #LCSM
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A #proteomics resource to aid research of parasite biology, pathogenesis, and drug and vaccine discovery in malaria. A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum–infected red blood cell proteome https://t.co/4niEcBa6GY
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