Cláudio Gomes Lab - Protein Misfolding in Disease
@ClaudioGomesLab
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Studying proteins and molecular mechanisms of misfolding and aggregation in Alzheimer's Disease and protein folding disorders at ULisboa
Lisboa, Portugal
Joined March 2019
Revisiting the "draw a picture of what you think my current life looks like based on what you know about me" challenge on ChatGPT5, roughly one year after the original
Weekend vibes: Took the "...draw a picture of what you think my current life looks like" challenge 😃 Loving the loft-office setup and all the whiteboard galore…in a lab coat, no less 🥼😅 And 'protein defolding'? Might have to bring that term to life 😅 Yours?
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Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab
biorxiv.org
The nascent polypeptide-associated complex (NAC) is a conserved ribosome-bound factor with essential yet incompletely understood roles in protein biogenesis. Here, we show that NAC is a multifaceted...
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The brain is the master regulator of food intake and energy balance. A brilliant new @CellCellPress review, including the mechanism of GLP-1 drugs, by @ClemmensenC and colleagues, open-access https://t.co/KbDf7ym288
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📣 Neurons respond to toxic Aβ oligomers by boosting S100B — a Ca-binding chaperone that protects the cytoskeleton and synapses from damage🧠 Collaboration with the Cardoso Lab, spearheaded by our joint PhD student Joana Saavedra 👩🔬👏 https://t.co/WTm20Y0x8k
frontiersin.org
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the intracellular deposition of Tau protein and extracellular deposition of...
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International Symposium on Protein Interactions and self assembly 🇵🇹 📣 Day 2 quick off with @LindorffLarsen talk on Predicting condensates of disordered proteins and many others to follow, poster pitches and session and lakeside lunch. #ISPIS2025 @cienciasulisboa @ULisboa_
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All set for the start of the 'International Symposium on Protein interactions and self assembly' in Lisbon 🇵🇹 later today. Excited to host an amazing lineup of speakers and 65 participants from all over during the next 3 days! #ISPIS2025 @TWIN2PIPSA @cienciasulisboa @ULisboa_
Still time to submit an abstract for a short talk! Join us in Lisbon to discuss all things protein — interactions, aggregation, phase separation, and more! 🗓️ Deadline 30 June
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Did you know that neuroscience played a key role in AI’s development? Artificial Intelligence: From Mind to Machine explores how brain research led to artificial neural networks, machine learning, and modern AI. Watch the full documentary: https://t.co/jj55CE1nbm
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Still time to submit an abstract for a short talk! Join us in Lisbon to discuss all things protein — interactions, aggregation, phase separation, and more! 🗓️ Deadline 30 June
📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: https://t.co/tEEXseACHa 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa
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📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: https://t.co/tEEXseACHa 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa
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Just out! A collaboration with the Herrera lab shows that S100B acts as a #chaperone supporting intermediate filament organization, compensating for sacsin loss in a cell model of Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) 📄 https://t.co/iyX5UsIIGV
link.springer.com
Molecular Neurobiology - Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurological disorder caused by mutations in the SACS gene, resulting in the loss of...
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Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research
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De novo design of high-affinity single-domain antibodies 1. The study introduces "EvolveX," a computational pipeline for de novo design of high-affinity single-domain antibodies (VHHs), capable of targeting predefined epitopes with remarkable precision and stability. 2. EvolveX
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Mapping Targetable Sites on the Human Surfaceome for the Design of Novel Binders 1. A groundbreaking study maps the human surfaceome, identifying 4,500 targetable sites across 2,886 cell-surface proteins. This resource unlocks new therapeutic opportunities for precision
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Predicting absolute protein folding stability using generative models More details 🦋👇
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🚨 Excited to announce the release of the DL4Proteins notebook series! 🌟 Learn AI for protein design with hands-on Colab tutorials inspired by the groundbreaking work of 2024 Chemistry Nobel Laureates David Baker, Demis Hassabis, & John Jumper. https://t.co/pi1tEwr0ij
github.com
Colab Notebooks covering deep learning tools for biomolecular structure prediction and design - Graylab/DL4Proteins-notebooks
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🆕 DisProt Release: Dec 2024 🆕 🧬 Age-related Disorders Proteins Dataset (45 proteins, 306 pieces of evidence). 🎯 Focus: IDPs in Neurodegenerative Diseases (e.g., Alpha-synuclein for Lewy body dementia). 📊 41 new proteins, 111 publications! Explore https://t.co/hKhdsGYygv now!
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🔊 90 seconds to explain our research on protein aggregation in Alzheimer's 🧠 🥼Obrigado @90segundosPT e @antena1rtp pela divulgação da nossa investigação e @adrijobecq pela entrevista🎙️🔬 @cienciasulisboa @ULisboa_ @BioISI 🔊 in 🇵🇹: https://t.co/bT08hJxrwB
Cláudio Gomes da @cienciasulisboa está a estudar os fatores que levam à deposição de agregados proteicos na doença de Alzheimer. https://t.co/AGdtu9iozB
#90SegundosCiência
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How are amyloid beta oligomers regulated by the S100 chaperone? https://t.co/AROuhY0FmI 🥼 #proudsupervisor
frontiersin.org
Extracellular aggregation of the amyloid-β 1-42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermedi...
Thrilled to have presented my #PhD 👨🔬work at the 6th students meeting of @ULisboa_ Mind-Brain College🧠 Kudos to all organizers for the amazing event! @ClaudioGomesLab @TWIN2PIPSA
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Biondi bodies, mysterious inclusions in the brain’s ependymal cells, are chock-full of TMEM106b fibrils. @IUMedSchool
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