Christine Moene
@ChristineMoene
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PhD student at the Netherlands Cancer Institute || gene regulation - epigenetics - genome organization || she/her
Joined June 2022
Did you ever wonder how transcription initiation compares between flies and mammals? The project that started as my master thesis in @arnaud_kr lab, was continued by @KCTattwo is now out on BioRXiv: Read his summary below:.
biorxiv.org
The general transcription machinery and its occupancy at promoters are highly conserved across metazoans. This contrasts with the kinetics of mRNA production that considerably differ between model...
Excited to share the latest story from the @arnaud_kr lab @embl ! Together with @ChristineMoene we used Single Molecule Footprinting to reveal that RNA Pol II occupancy occurs at surprisingly low-frequency at mammalian promoters! Thread below (⬇️) 1/11
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The first story of my PhD is now available as pre-print: We used highly multiplexed local reporter hopping to map the functional landscape of the Sox2 locus. My colleague, friend & co-author @MathiasEder91 summarized the highlights for you:.
biorxiv.org
Genes are often activated by enhancers located at large genomic distances. The importance of this positioning is poorly understood. By relocating promoter-reporter constructs into >1,000 alternative...
1/8 We developed a transposon based methodology that allows us to systematically study the positional relationship between the mouse Sox2 gene and its distal enhancer (SCR). In one experiment we can obtain and map integrations at more than 2000 unique positions.
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RT @StasOCW: Wat een knappe prestatie! Super dat deze leerlingen zo goed scoren op de internationale biologie-olympiade. Van harte gefelici….
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RT @bvansteensellab: . and we used our platform of 19 chromatin-integrated pathway reporters to probe context-dependent effects of epigen….
academic.oup.com
Abstract. The efficiency and outcome of CRISPR/Cas9 editing depends on the chromatin state at the cut site. It has been shown that changing the chromatin s
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RT @bvansteensellab: We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-depe….
nature.com
Nature Communications - DNA double-strand breaks are repaired by multiple pathways. The balance of these pathways depends on the local chromatin context, but the underlying mechanisms are poorly...
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