Chih-Hao Lu
@ChihHaoLu_TW
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A Biophysicist, Cell Biologist and Chemist from @BianxiaoC Lab at @StanfordUChem. 🇹🇼🇺🇸
Stanford, CA
Joined December 2023
Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag https://t.co/dtsXcYAsYH
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Cell membranes shaped and cut by phase-separated liquid protein condensates https://t.co/dnaRb8XMIK
nature.com
Nature - Membrane bending and cutting can be mediated by biomolecular condensates, as well as by the conventional protein machinery.
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Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking. https://t.co/6ZRWaj6I3f
nature.com
Nature Chemistry - Now a generalizable method that couples spatially directed tagging with condensation-enhanced crosslinking—termed DenseMAP—has been developed for profiling the...
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Tracking transcription–translation coupling in real time https://t.co/E6bYPFtLiG
nature.com
Nature - Single-molecule fluorescence microscopy experiments with a recombinant Escherichia coli transcription–translation system provides insights into the coordination of the transcription...
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Big congratulations to #TeamTaiwan for your ace performance! You’ve just made history by bringing home Taiwan's first @Premier12 baseball championship. Your teamwork & perseverance inspire us all!
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Feng, Cai, Xu et al. @ZJU_China report that saturated fatty acids cause mitochondrial damage and ROS elevation in human endothelial cells. Activation of #lysosome biogenesis using TRPML1 agonists is sufficient to mitigate SFA-induced #mitochondria damage. https://t.co/zxOKEUcOvw
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Published in @ScienceMagazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) https://t.co/oRfPLYlJBY
@mpi_nat @mpi_mr_hd #Optics #Imaging #Microscopy #MINFLUX #Fluorescence
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel to Daron Acemoglu, Simon Johnson and James A. Robinson “for studies of how institutions are formed and affect prosperity.”
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BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2024 #NobelPeacePrize to the Japanese organisation Nihon Hidankyo. This grassroots movement of atomic bomb survivors from Hiroshima and Nagasaki, also known as Hibakusha, is receiving the peace prize for its
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Direct optical measurement of intramolecular distances with angstrom precision | Science
science.org
Optical investigations of nanometer distances between proteins, their subunits, or other biomolecules have been the exclusive prerogative of Förster resonance energy transfer (FRET) microscopy for...
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BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Congratulations to our 2024 medicine laureate Victor Ambros ✨ This morning he celebrated the news of his prize with his colleague and wife Rosalind Lee, who was also the first author on the 1993 'Cell' paper cited by the Nobel Committee. #NobelPrize
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Congratulations to Gary Ruvkun, professor of genetics at Harvard Medical School and an investigator at @MassGeneralNews, for winning the 2024 #NobelPrize in Physiology or Medicine!
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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💫NEW: Yang et al show that #PlasmaMembrane curvature promotes the site-specific formation of contacts with the #EndoplasmicReticulum through junctophilin-2 tethers in #cardiomyocytes. @cuilab_chem @StanfordUChem @Stanford_CHEMH @BianxiaoC @YangYang0511
https://t.co/Q0QugJRMhv
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Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem
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Membrane curvature promotes ER-PM contacts in cardiomyocytes. Excited to share our work published in Nature Cell Biology today. Congratulations to Yang and the team! https://t.co/ylGXgzRqMm
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Thrilled to share that I will join @JohnsHopkins @JHUBME as an Assistant Professor in 2025! The Yang Lab will develop novel bioelectronics and biomaterials for brain-machine interfaces, regenerative medicine, and the study of human neural development and diseases.
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On how membrane curvature allows our hearts to beat…💓 #preLighter Barbora Knotkova highlights a beautiful #preprint from @YangYang0511 @ChihHaoLu_TW @chingtingtsai @santorof14 @Zjahed @jen_liou @Joseph_C_Wu @BianxiaoC. preLight + author response ⬇️ 👀 https://t.co/ZF0FJLcvtE
prelights.biologists.com
This is how membrane curvature makes our hearts beat - Junctophilins interact with EHD proteins to connect the sarcoplasm to t-tubules and thus enable excitation-contraction coupling in heart muscle...
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Membrane curvature promotes ER-PM contact and dyad formation in cardiomyocytes. @YangYang0511 @chingtingtsai @ChihHaoLu_TW @santorof14 @Zjahed @jen_liou @Joseph_C_Wu Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions
biorxiv.org
Contact sites between the endoplasmic reticulum (ER) and the plasma membrane (PM) play a crucial role in governing calcium regulation and lipid homeostasis. Despite their significance, the factors...
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