Chiara Falcomatà
@ChiaraFalcomata
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@CancerResearch postdoc in Brown lab, Icahn School of Medicine at Mount Sinai | pancreatic cancer immunology
Manhattan, NY
Joined March 2020
RT @Aiims1742: Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanI….
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RT @MaxReichertMD: 🤩Super excited our branched #PancreaticCancer #Organoids to capture tumour heterogeneity made it on the cover of @natBME….
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Check out the preprint for all the data, figures, and amazing co-authors!.@Brown_lab1 #ImmunoOncology #CRISPRscreen #SpatialBiology #ECM #PDAC #CancerImmunology.(8/8).
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This changes our view of the ECM: it’s not just a passive barrier, but an active player in immune evasion. (7/8).
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Deleting Serpine1 or Serpinb2:.✓ Remodels the ECM.✓ Reduces immunosuppressive macrophage accumulation.✓ Permits T cell infiltration.✓ Synergizes with anti-PD-1 immunotherapy, increasing survival.(6/8)
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⭐️ Key finding: Loss of Serpine1 (PAI-1) or Serpinb2 (PAI-2) impairs tumor fitness in an immune-dependent way. These serpins shape a fibrin-rich ECM that recruits macrophages, building local immunosuppressive niches. (5/8).
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We applied Perturb-map (Dhainaut et al., Cell 2022) to perform a spatial CRISPR screen of extracellular factors in orthotopic PDAC models. This let us track over space and time:.✓ Clonal selection.✓ TME remodeling.✓ Immune reprogramming .(4/8)
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Why?.The PDAC tumor microenvironment (TME) is dense, fibrotic, and profoundly immunosuppressive. T cells are excluded or suppressed, and the extracellular matrix (ECM) may physically and functionally block immune infiltration. But how ECM components do this is unclear. (3/8).
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#PDAC is one of the deadliest cancers—and is on track to become the 2nd leading cause of cancer death. (2/8).
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🚨 Our new #preprint is out!.We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8).
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RT @Aiims1742: HUGE congratulations to @IamLinghua & team for her latest @Cancer_Cell study .Integrative analyses of over 14 million cells….
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RT @fabian_theis: 1/ Excited to see published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics….
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RT @Brown_lab1: @SantagataMDPhD @JoshuaBrodyMD @yizhoudonglab More details on 'Bispecific antibody targeting of lipid nanoparticles' in the….
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RT @Brown_lab1: First lab tweet! Sharing new papers:.PRINT Using Perturb-map, we show how ovarian tumors resist immunotherapy https://t.co/….
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RT @TuomasTammela: Several years in the making (and aging), @Xueqian_Zhuang 's study on aging is out today @Nature. She finds, surprisingly….
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RT @obenaufa: So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic….
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RT @parigi_martina: Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! https:….
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RT @Aiims1742: New study in @Nature today:.Clinical functional proteomics of intercellular signalling in #PancreaticCancer..
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RT @TischCancer: Ovarian cancer-derived IL-4 promotes immunotherapy resistance: Cell .@IcahnInstitute @IcahnMountSi….
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RT @Aiims1742: First of a series of papers from the @NCIHTAN is out in @Nature this morning. Tumour evolution and microenvironment interac….
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