Chee Wah Tan
@CheeWahTan2
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Research Assistant Professor@NUS, Virologist 🦠, bats🦇, father of two 🇲🇾🇸🇬
Singapore
Joined January 2019
A virus won’t go from “nothing” to “crisis” overnight—but ignoring it is like smelling smoke and thinking, “Eh, probably just toast.” Spoiler: it’s not toast. Early Warning is everything. Fund and improve systems that keep the kitchen from burning down. https://t.co/S5nbrdXL15
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Join me at @NUSMedicine for my seminar next week. A chance to discuss and set up more collaborations within the NUS infectious diseases ecosystem
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Please join us by registering with Zoom link and share to your network to learn more about Nipah from @linfa_wang, severe fever with thrombocytopenia syndrome from Professor Dongmin Kim and one health AMR in China from Professor Yonghong Xiao
📢Webinar announcement We invite you to a collaborative webinar with ISAC Member Society, Asia Pacific Society of Clinical Microbiology & Infection (APSCMI) "One health aspects of AMR and infections in Asia" 📅9 May 2024 Register⬇️ https://t.co/rH3xXIiJzS
#Onehealth #IDxposts
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Now published @eBioMedicine—“#Mucosal #SARSCoV2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern” https://t.co/OMHNVIi1Zy w/ co-au O'Neill @Shashank_IISc @cheewahtan2 @ChinmayMantri @Abhay_R_
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mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting
biorxiv.org
To address the limitations of whole-spike COVID vaccines, we explored mRNA vaccines encoding membrane-anchored receptor-binding domain (RBD-TMs), each a fusion of a variant RBD, the transmembrane...
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Meet the Batman – Prof Linfa Wang FAA FTSE. Like the eponymous hero, his superpowers are his vast subject knowledge and willingness to answer the call to action. The bat expert had been considering retirement but was quick to step up when COVID struck. https://t.co/qSem4NHfsB
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Need a human cell line to isolate and propagate SARS-CoV-2 in high titers? Here we have characterized “IGROV-1”: https://t.co/BLyG9IA7la + CRISPR screens identifying AHR as a host proviral factor of human betacoronaviruses @yaw_shin @CheeWahTan2 @GavinJDSmith @linfa_wang
tandfonline.com
The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we h...
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🦇news: Body temperature in #bats dramatically impacts their #antibody repertoires. High 🌡️leads to preferential recognition of damaged cells, indicating an anti-inflammatory function. #preprint
https://t.co/8UcOU5QTcz
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Your academic CV is NOT linked to your ability to make big discoveries. ▫️ 1. Andre Geim, a co-discoverer of graphene, wrote in his Nobel Lecture article: - “So, at the age of 33 and with an h index of 1 (latest papers not yet published), I entered the Western job market for
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@DukeNUS research finds antibodies that neutralise COVID variants and other animal coronaviruses. By targeting conserved spike regions, the antibodies could enable universal coronavirus vaccines and therapeutics. Major advance for pandemic preparedness! https://t.co/FKrteZRvYZ
duke-nus.edu.sg
Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses.The antibodies targeted a...
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This paper from Linfa Wang’s group to which @tylernstarr & I contributed illustrates interesting points about 1⃣ Importance of imprinting for antibody specificity to SARS-like CoV 2⃣ How it may be easier to broadly neutralize animal sarbecoviruses than human #SARSCoV2 variants
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor | Science Advances
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Pan-sarbecovirus monoclonal antibodies can be a good pandemic preparedness strategy for SARS3 buying time for specific mAb and vaccines. IC50 E7 dropped with XBB otherwise active SARS1 and SARS2. 1/2 https://t.co/w5DuLrT8tv
science.org
A potent, broad-spectrum human monoclonal antibody capable of neutralizing all ACE2-binding sarbecoviruses is identified.
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Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor | Science Advances
science.org
A potent, broad-spectrum human monoclonal antibody capable of neutralizing all ACE2-binding sarbecoviruses is identified.
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Distinctive serotypes of SARS-related coronaviruses defined by convale...
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Possibility of #Postdoc in #viral research in Cambodia with the Virology Unit at IPC. Still time to apply for a competitive #scholarship, but no guarantees. A unique chance to work on the frontlines of #emergingdiseases.
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It's finally out! an exciting paper almost 4 years in the making: BTN3A3 evasion promotes the zoonotic potential of influenza A viruses in @Nature Here's a 🧵 about how 🐓 influenza A viruses cross the species barrier https://t.co/jtHIvFrePr
nature.com
Nature - A protein that evolved in primates, BTN3A3, is expressed in human airways and shows antiviral activity against avian IAVs but not against human IAVs.
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🎉👏 Congratulations @linfa_wang for being selected as a finalist in the #FallingWalls Science Breakthroughs of the Year 2023 in the category of Life Sciences! Check out the list of finalists at https://t.co/pgNUxO6CQx.
#DukeNUS #LifeSciences #bats #viruses
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Broad-spectrum pan-genus and pan-family virus vaccines: Cell Host & Microbe
cell.com
The COVID-19 pandemic demonstrated both the importance and challenges in producing long lasting and broadly protective vaccines. This review discusses the current status and future directions in...
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Great to write this review with @CheeWahTan2 @world_epidemic @linfa_wang covering universal broadly reactive vaccine space for influenza, Nipah and coronaviruses https://t.co/Ztk5fzjogE
@HKU_Pasteur @dukenus @TheDohertyInst
cell.com
The COVID-19 pandemic demonstrated both the importance and challenges in producing long lasting and broadly protective vaccines. This review discusses the current status and future directions in...
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