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Chase Mackey

@Chase_Mackey

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Neuroscientist interested in how we hear in complex environments. Research Scientist at Nathan S. Kline Institute. Orangeburg, NY, USA.

Joined January 2011
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@Chase_Mackey
Chase Mackey
10 months
If you’re interested in multisensory integration 🦻👀, face/vocalization perception in monkeys🐒, or cortical microcircuits, take a look:. Our new paper on the laminar pattern of visual, and audiovisual, responses across the cortical hierarchy is out now.
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academic.oup.com
Abstract. Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear becaus
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@Chase_Mackey
Chase Mackey
2 months
RT @pgmid: I'm not sure what a representation is anymore. or maybe I never knew. These fine folks have some thoughts. .
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@Chase_Mackey
Chase Mackey
2 months
RT @CoryMillerMarmo: Here is my OpEd about the impacts of restructuring the NIH
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thehill.com
Merging smaller institutes into larger ones would increase bureaucracy, not reduce it. 
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@Chase_Mackey
Chase Mackey
3 months
RT @pfapostolides: (Plz repost). I’ve been receiving some good news lately and will be hiring at all levels to expand the lab. Please get i….
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@Chase_Mackey
Chase Mackey
5 months
RT @Macacophile: The new NIH director says “Second, NIH-supported science should be replicable, reproducible, and generalizable.”. NHP are….
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@Chase_Mackey
Chase Mackey
5 months
RT @neuralreckoning: I wrote a thing for @_TheTransmitter. The attack on scientific infrastructure happening in the US shows that relying o….
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@Chase_Mackey
Chase Mackey
10 months
Are you a lumper or a splitter? . Our assessment of a recent Nature Neuroscience paper by Mendoza-Halliday, Major, Desimone, Miller, Bastos et al. is up on BioRxiv.
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@Chase_Mackey
Chase Mackey
11 months
RT @Chase_Mackey: Our new paper, led by Yoshi Kajikawa, on dynamic high frequency oscillations in auditory cortex is out now in Cerebral Co….
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@Chase_Mackey
Chase Mackey
11 months
All of which suggests a good deal of complexity underlying “broadband” high frequency activity. Twitterless Yoshi Kajikawa did a great job carrying the team on this one! .
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academic.oup.com
Abstract. High-frequency (>60 Hz) neuroelectric signals likely have functional roles distinct from low-frequency (<30 Hz) signals. While high-gamma a
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@Chase_Mackey
Chase Mackey
11 months
To address this, we analyzed spectrotemporal laminar profiles of gamma activity in auditory cortex. We found high frequency oscillations not phase locked to stimuli, with dynamic frequency content that shifted rapidly from ~150 to 60 Hz.
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@Chase_Mackey
Chase Mackey
11 months
High gamma activity is often considered broadband, and is analyzed in terms of power, without much consideration for the polarity of the underlying signal. To address this, we analyzed spectrotemporal gamma activity.
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@Chase_Mackey
Chase Mackey
11 months
Our new paper, led by Yoshi Kajikawa, on dynamic high frequency oscillations in auditory cortex is out now in Cerebral Cortex! Thread below.
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@Chase_Mackey
Chase Mackey
11 months
That integrate information over time. We (@adriana_et_al and I) modeled this using a drift diffusion model that captured individual NHPs’ accuracy and reaction times remarkably well. Enjoy: (End).
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journals.physiology.org
Sinusoidal amplitude modulation (SAM) is a key feature of complex sounds. Although psychophysical studies have characterized SAM perception, and neurophysiological studies in anesthetized animals...
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@Chase_Mackey
Chase Mackey
11 months
We then turned to the question of how we integrate AM over time to make temporal discriminations. By altering signal duration, we found that NHP perception was more robust at short durations than CN and IC responses, and that performance may be best explained by brain structures.
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@Chase_Mackey
Chase Mackey
11 months
What we find is single units in the IC, and small populations in the CN, were sufficient to discriminate AM as well as NHPs, regardless of whether a rate or spike timing code was used.
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@Chase_Mackey
Chase Mackey
11 months
We viewed this as an opportunity to capitalize on the translational value of our NHP model, which enabled us to evaluate the degree to which the AM encoding literature in small animals matches the NHP model, and accounts for primate (human OR nonhuman) auditory perception.
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@Chase_Mackey
Chase Mackey
11 months
We used a nonhuman primate model to better understand how single neuron activity in the cochlear nucleus and inferior colliculus contribute to sound envelope discrimination. Single unit subcortical data from awake NHPs are scarce, particularly in the CN.
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@Chase_Mackey
Chase Mackey
11 months
At long last, our (@RamRamLab) paper on the subcortical encoding of sound envelope is out! 🔊🐒. Thread below. Ahead of print paper at J Neurophysiol: . Preprint:
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journals.physiology.org
Sinusoidal amplitude modulation (SAM) is a key feature of complex sounds. Although psychophysical studies have characterized SAM perception, and neurophysiological studies in anesthetized animals...
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@Chase_Mackey
Chase Mackey
1 year
RT @JP__NOEL: Add for post-doc position in my lab at @UMNeurosci. Please apply or forward to anyone you think maybe interested!!. https://t….
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@Chase_Mackey
Chase Mackey
1 year
RT @GauteEinevoll: Episode #14 in #TheoreticalNeurosciencePodcast: On the molecular memory code – with Sam Gershman.@gershbrain . https:/….
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