Camilla Schytz
@CSchytz
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PhD student @ Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
Joined January 2012
News from our lab: 4 weeks of high altitude decreases human skeletal muscle mitochondrial cristae density, while mitochondrial respiration increases: https://t.co/26tFwv88ws Carsten Lundby, @DrRajacobs, @JoachimNielsen6, @nortenblad, Stine Lundby @sduiob @teamdanmark
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Research Article by @CSchytz et al. (@nortenblad @JoachimNielsen6 @DrRajacobs) Effect of #highaltitudeexposure on #skeletalmuscle #mitochondrial #subcellulardistribution, #ultrastructure, and #respiration in sea-level residents https://t.co/HJHMywKDCZ
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Join our PhD course in metabolism and EC coupling. November 10-15. University of Southern Denmark. Enrol here: https://t.co/zx3rpq2fRW
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Our sea-level friends at @SyddanskUni provide today's #ArticleinPress, Effect of high-altitude exposure on #skeletal #muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents (Camilla Tvede Schytz et al.): https://t.co/2PePKqLJxu
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I am thrilled to share one of the first major works from my postdoc in Amsterdam, "Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity", published online yesterday in @AgingCell
https://t.co/mRE5sKcNQy. A thread:
onlinelibrary.wiley.com
When comparing young versus middle-aged individuals, we found that older individuals possessed a reduced skeletal muscle subsarcolemmal mitochondrial density, a more fragmented intermyofibrillar...
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How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes? Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it https://t.co/McNw5KrKC6
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Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site | Science Advances
science.org
Reorientation of a positively charged binding site drives adenine nucleotide exchange in the presence of a membrane potential.
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Our latest paper on aging is finally out in @ExpPhysiol. This is a real IHC tour de force on muscle morphology, satellite cells, capillaries and innervation status so if you are into that, check it out! @SebastianEdman @MobergPhD @andyphilp_lab @WiApro
https://t.co/5CWKhGigGC
physoc.onlinelibrary.wiley.com
Age-related loss of muscle mass and function is underpinned by changes at the myocellular level. However, our understanding of the aged muscle phenotype might be confounded by factors secondary to...
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Is mitochondrial morphology important for cellular physiology?: Trends in Endocrinology & Metabolism
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Thanks to Carsten Lundby, @DrRajacobs, @JoachimNielsen6, @nortenblad, and Stine Lundby for their expertise and dedicated work. @sduiob @teamdanmark 6/6
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If supported (the 95% confidence intervals included trivial effects), our results suggest that high-altitude exposure enhance the respiratory efficiency of the mitochondrial network. 5/6
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Despite the reduced MuscularCD, mass-specific maximal coupled respiration increased slightly but was considerably elevated when normalised to MuscularCD suggesting intrinsic respiratory adaptations to high altitude. 4/6
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Moreover, although the mitochondrial volume density increased, the cristae surface area per skeletal muscle fibre volume (MuscularCD) decreased because of a substantial decline in the mitochondrial cristae density (shown for the first time to change in humans!). 3/6
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We found that exposing sea-level residents to high altitude (3454 m) induced an altered subcellular distribution, prioritizing the intermyofibrillar pool of mitochondria. 2/6
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New preprint, the first after my my PhD. Link to article: https://t.co/EVm0uXiWWx We investigate how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic mitochondrial respiratory capacity. 1/6
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Happy to see that our comprehensive meta-regression, "Effects of Exercise Training on Mitochondrial and Capillary Growth in Human Skeletal Muscle," by @Skattebo_Oyvind, @AlmquistNicki, and myself, is now published in @SportsMedicineJ! 🎉more details soon! https://t.co/tlN9fHDOse
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A study reveals that the distance between the endoplasmic reticulum and mitochondria is crucial for optimal mitochondrial Ca2+ uptake and oxidative metabolism. This is an important finding in terms of muscular energy efficiency.🔬 https://t.co/kURHS9oI7b
nature.com
Communications Biology - The distance-dependence analysis of ER-mitochondria Ca2+ transfer suggests that a distance of ∼20 nm between the organelles ensures maximal efficiency of...
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@AtHinton just dropped a beautiful new paper with amazing serial blockface SEM imaging of aging muscle tissues 🙌🙌🙌 https://t.co/Db2fS0OVbi
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Does one biopsy cut it? Short answer: no. Find out the longer answer below 🧵👇 This thread is based on our new @japplphysiol paper, where we investigated human muscle fiber type composition variability by analyzing repeated biopsies. Lots of them. https://t.co/6yAHbrurqc
journals.physiology.org
Human skeletal muscle fiber type composition varies greatly along the muscle, so one biopsy may not accurately represent the whole muscle. Recommendations on the number of biopsies and fiber counts...
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