News from our lab: 4 weeks of high altitude decreases human skeletal muscle mitochondrial cristae density, while mitochondrial respiration increases:. Carsten Lundby, @DrRajacobs, @JoachimNielsen6,.@nortenblad, Stine Lundby .@sduiob @teamdanmark

RT @MitoPsychoBio: Unhappy muscle mitochondria can look like this.

RT @RichieGoulding1: I am thrilled to share one of the first major works from my postdoc in Amsterdam, "Skeletal muscle mitochondrial fragm….

RT @Nature: How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes? . Segregation into distinct….

RT @bioblastgeek: Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charge….

RT @HorwathOscar: Our latest paper on aging is finally out in @ExpPhysiol. This is a real IHC tour de force on muscle morphology, satellite….

RT @bioblastgeek: Is mitochondrial morphology important for cellular physiology?: Trends in Endocrinology & Metabolism .

Thanks to Carsten Lundby, @DrRajacobs, @JoachimNielsen6, @nortenblad, and Stine Lundby for their expertise and dedicated work. @sduiob @teamdanmark. 6/6.

If supported (the 95% confidence intervals included trivial effects), our results suggest that high-altitude exposure enhance the respiratory efficiency of the mitochondrial network. 5/6.

Despite the reduced MuscularCD, mass-specific maximal coupled respiration increased slightly but was considerably elevated when normalised to MuscularCD suggesting intrinsic respiratory adaptations to high altitude. 4/6.

Moreover, although the mitochondrial volume density increased, the cristae surface area per skeletal muscle fibre volume (MuscularCD) decreased because of a substantial decline in the mitochondrial cristae density (shown for the first time to change in humans!). 3/6.

We found that exposing sea-level residents to high altitude (3454 m) induced an altered subcellular distribution, prioritizing the intermyofibrillar pool of mitochondria. 2/6.

New preprint, the first after my my PhD. Link to article: We investigate how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic mitochondrial respiratory capacity. 1/6

RT @MrMoelmen: Happy to see that our comprehensive meta-regression, "Effects of Exercise Training on Mitochondrial and Capillary Growth in….

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RT @AuPhysiolSoc: Invited speaker Joachim Nielsen showcasing some amazing EM work looking at Glycogen. #bmh2024 #AuPS2024 @bmh2024Melb http….