Christian Ottmann
@COttmann1433
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Co-Founder and CSO of Ambagon Technology and Associate Professor at Eindhoven University of Technology.
Eindhoven, NL
Joined April 2020
Our work on the role of 14-3-3 in reducing condensation and aggregation of Tau is out in Communications Biology. Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation | Communications Biology.
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Our story with the groups of Don Scott and Markus Kaiser on Molecular Glues of the 14-3-3/ChREBP complex is out in Nature Communications:.Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity | Nature Communications.
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Check out our review on the structural biology of molecular glues written with friends from RevMed:.
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Have a look at our collaboration paper with Donald Scott's and Markus Kaiser's group. We show that a molecular glue of the 14-3-3 complex with the transcription factor ChREBP prevents human beta cell death. Might be useful in T2D and showcases the value of 14-3-3 molecular glues.
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RT @tuecursor: Hoogleraar Luc Brunsveld vindt dat universiteiten terughoudend moeten zijn met politieke standpunten. "Onderwijs middels exc….
cursor.tue.nl
Begin 2011 werd er door het TU/e College van Bestuur aardig wat druk uitgeoefend op de lokale hoogleraren om in Den Haag mee te gaan demonstreren tegen de bezuinigingsplannen van Rutte I. Naast dat...
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RT @AdrianBebenek: Awesome paper from @DanNomura showing the first YAP/TAZ — 14-3-3 molecular glues! Building off of seminal work by @Miche….
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RT @angew_chem: During the pandemic, what was the silver lining in the collaborative work in the Arkin and Renslo labs at UCSF and the Brun….
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We have another story out from our ongoing collaboration between TU Eindhoven and UCSF, describing in JACS how we optimized a non-selective molecular glue fragment towards selectivity for ERalpha binding to 14-3-3.
pubs.acs.org
The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery. The identification of suitable starting points for stabilizing...
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Check out our new paper in Angewandte with the first (to our knowledge) molecular glue from a linked fragment. Thanks for again a great collaboration between Eindhoven University of Technology and UCSF!.
onlinelibrary.wiley.com
Linked fragments for molecular glue development for the 14-3-3/ERα protein-protein interactions (PPIs) are described. Two classes of fragments were co-crystallized and subsequently linked, resulting...
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RT @ambagontx: Our co-founders, Luc Brunsveld, @MichelleArkin & @COttmann1433 recently published a paper on a molecular lock approach that….
pubs.acs.org
Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool compounds for biophysics and (structural) biology, and as starting points for molecular glue drug discovery....
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Check out our paper on target identification of 14-3-3 clients after combined IFN and Fusicoccin treatment:
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RT @StephanHacker2: Great talk by @COttmann1433 at the @LED3hub Talks. He told us about his group's research into the stabilization of prot….
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RT @pottslab: New Today! Induced Proximity group at @Amgen publish in @rsc_chembio on Protein–protein interfaces in molecular glue-induced….
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