Matthew Brown
@BrownMatthewE
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Check out the latest work from @Bruskolab and @TheRussLab in @ScienceAdvances, describing a novel approach to enhance the protection of stem cell derived pancreatic beta-cells from cytotoxic immune cells using an optimized CD155 protein for #T1D replacement therapies by authors
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🧪 Th1nk Tank Alert! Join us for an exciting talk on groundbreaking T1D research https://t.co/zTIET80yxK
#T1DResearch #Autoimmunity #Tregs #CD226 #EffectorTCells #Immunology #DiabetesResearch #BetaCellPreservation #TranslationalScience #NODMouse
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Our new review on AI/ML applications toward #T1D immunotherapy is out in @DiabetologiaJnl about drug repurposing, precision medicine & more! Thanks to collaborators: @BrownMatthewE @Bruskolab @drdrmark @ResearchCM, funders: @BreakthroughT1D @NIDDKgov @HelmsleyTrust
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Check out the latest work from @Bruskolab in @DiabetologiaJnl , describing α-CD226 as a novel immunotherapy candidate which protects against #T1D in NOD mice by authors @BrownMatthewE @PuchongThi @leeanadenise @rbacher @BruskoMaigan @Mel_Shapiro_PhD thanks to support from
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α-CD226 protects against #T1D in NOD mice. Considerations for future translation by @BrownMatthewE @PuchongThi @leeanadenise1 @rbacher @BruskoMaigan @Mel_Shapiro_PhD @Bruskolab and thanks to @NIDDKgov @DiabetesRsrch @BreakthroughT1D @ADA_DiabetesPro
https://t.co/qAFM1ip42g 🔓
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Through clinical and world-renowned research programs, as well as community outreach, the University of Florida is making headway in improving the lives of people affected by diabetes at the local level and beyond. Click this link to read this new feature https://t.co/iHeygHaGSq
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Congratulations to @Mel_Shapiro_PhD for winning a poster award at #IDS2024 and for the hard work our @ufdiabetes team!
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We report on monoclonal Ab blockade of CD226 in the NOD model as a first step toward translation to clinical immunotherapy in T1D @BrownMatthewE @PuchongThi @leeanadenise @rbacher @BruskoMaigan @Bruskolab
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Check out our latest work demonstrating α-CD226 mAbs reduce diabetes in NOD mice by augmenting Treg and reducing effector T cell function.
biorxiv.org
Aims/hypothesis Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. A growing number of T cell-directed...
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Metabolic hormones as an underappreciated signal 3 for T cells? Check out our newest work @J_Immunol. Thanks to @leeanadenise1 @BrownMatthewE Bayerlab @Bruskolab @NIDDKgov @NIAIDFunding @JDRF @DiabetesRsrch @HelmsleyTrust @Diabetes_DRI for collaboration! https://t.co/T5O2cFqas4
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CD226 co-stimulation in Tregs contributes to instability and diabetes in NOD mice. Please see our publication in @Diabetes_ADA. Thank you to @BruskoLab @BrownMatthewE @MelanieShapiro @NIDDKgov for the support! https://t.co/15rbucs4Xt
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