#BRI Study of the Year👨‍🔬 T Cell Response Targets Infection Without Antibodies in Humans🛡️ Most therapies focus on anti-viral drugs or antibody-based vaccines. This study may encourage the development of therapeutics focused on promoting T Cell replication for pathogen defense.

New Study Reveals How Macrophage 'fuel' Shortages Shape Atherosclerosis🫀 “A specific transporter protein, SLC7A7, acts as a gateway that allows glutamine to enter the cell. When this gateway is blocked, macrophages lose energy and perform poorly, resulting in plaques that are

Why scientists are rethinking the immune effects of SARS-CoV-2 « A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems » The proof is all around us …

Study Demonstrated How Destroying Senescent Cells Mitigated Epilepsy 💢 “Treatment to remove the aging cells in mice resulted in a 50% reduction in these senescent cells, normalized their ability to navigate mazes, reduced seizures and protected a third of animals from epilepsy

This may be disruptive for many in cancer research. The Warburg effect and lactate production are not exclusive to glucose. They can also be driven by fructose and even galactose. We compared (unpublished data) how breast cancer cells handle glucose, fructose and galactose,

1️⃣ Lactate isn’t waste, it’s a central regulator of the tumor microenvironment (TME). It shapes immune responses, stromal behavior, angiogenesis, EMT, drug resistance, and metabolic reprogramming. 2️⃣ Lactate connects metabolism to epigenetics via lactylation, modifies signaling,

If a military team made a mistake during a nuclear-war preparedness exercise and accidentally obliterated 20 million people, you would not expect to find some of the very same people merrily admitting a couple of years later that they had done it again. Would you?

"The Wuhan lab…that conducted risky experiments on bat viruses…and almost certainly caused the pandemic has now revealed…it has done the same…risky experiments on another lot of horseshoe-bat viruses" https://t.co/dr7m6UOgEn

##Aspartame reduces fat deposits in mice but induces mild cardiac hypertrophy and impairs cognitive performance, even at doses well below current human safety guidelines. @cicbiomagune https://t.co/TUEinFO2lg

Wow. A drug to treat blood clots is their number one prescribed medicine?!

Do Condensates Affect Electrical Membrane Potential? “You can think of condensates as electrically charged droplets in the cell, kind of like a tiny battery… Since condensates can often be charged, we wanted to test whether they can induce voltage changes across the cell

Besides amino acids made from scarce single-nitrogen molecules, another crucial building block hard for life to get from the environment is phosphate, out of which is made the core molecules of life: DNA, RNA, and the ubiquitous energy molecule adenosine triphosphate (ATP).

“P021 has been able to rescue dendritic & synaptic deficits by boosting neurogenesis, preventing neurodegeneration, Aβ, and tau pathologies, rescuing cognitive impairment in Alzheimers mice as well as markedly reducing age-related mortality in rat.” P021: https://t.co/RDsFsNiu17

Practical experimenters had cracked a deep & ancient secret of life, greatly increasing biological scalability over the course of a mere century, creating new muscle & brain power & boosting the productivity of agriculture, freeing up workers for much bigger industrial scales.

Thymalin boosts immune system while mitigating fever and excess cell death induced by cytokine storms. #Peptides #Cytokines #Alveoli #Fibrosis #COVID19 https://t.co/8nFWcQZYh4 "Uncontrolled development of the initial [cytokine storm] stage inevitably leads to immune imbalance."

Biological scalability is the ability to support a larger, denser, and/or wealthier population in a given ecosystem.

Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver. https://t.co/R9w9iWOiD4 By: @ArkadyMazin

Tiny Plastic Particles Found in Artery-Clogging Plaque in the Neck 🧈 “While microplastics are sometimes visible at less than 5 millimeters in size, nanoplastics are microscopic, less than 1,000 nanometers across.” https://t.co/G6Uyij7tMD

SARS-CoV-2 fragments mimic host immune peptides, forming RNA-protein complexes that hyperactivate TLR3 in uninfected cells. This immunomimetic pathway drives systemic inflammation, explaining long COVID’s persistent cytokine storm. https://t.co/noeYuUnAXx

Aging and chronic disease share a unifying root: metabolic reprogramming of macrophages. When energy production shifts from repair (OXPHOS) to inflammation (glycolysis), the immune system becomes the disease itself. Longevity begins with immune metabolism.

AlphaFold went from zero to 240 million protein structures in five years, with researchers using it submitting 50% more validated structures than other methods. Few tools in history have reshaped a field this fast.