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@ArrigeOrg

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Association for Responsible Research and Innovation in Genome Editing. Towards the responsible use of genome editing technologies. https://t.co/D6W0dqBbFk

Paris, France
Joined March 2018
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@ArrigeOrg
ARRIGE
11 months
Our new President Hervé Chneiweiss has prepared this welcome message for ARRIGE members and associated colleagues. It includes his vision for the future of our association. https://t.co/rcLMnGWaC4
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@ArrigeOrg
ARRIGE
3 days
We have released the 2025 ARRIGE annual meeting summary and statement. You can download it and read it from @ArrigeOrg web site: @LluisMontoliu @MartinaCrispo https://t.co/eOIQs0lFuZ
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@LluisMontoliu
Lluis Montoliu
1 month
If you want to know the meaning and fears behind the saying: “opening the Pandora box” just read this article in @Nature about a company called Manhattan Genomics run by someone called Biotech Barbie. She is planning to edit human embryos, and is not alone https://t.co/akRmmw0Luz
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@ArrigeOrg
ARRIGE
2 months
@UrnovFyodor @kiranmusunuru Today, 29 Oct, we will continue our annual meeting with yet another interesting session on “Ethical and Policy Challenges: Access, Incentives, IP, Responsibilities” with Julian März, Pawel Lukow, Paul Aliu and Daima Bukini. We’ll finish with a roundtable. https://t.co/8XceitqB1d
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@ArrigeOrg
ARRIGE
2 months
Oir first panel is on “Technicalities” with @UrnovFyodor @kiranmusunuru and Marina Cavazzana
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@ArrigeOrg
ARRIGE
2 months
We are starting our 2025 ARRIGE annual meeting focused on “access and affordability of gene therapies: challenges for genome editin” both online and in person in Strasbourg. Keynote speaker is Alta Charo https://t.co/8XceitqB1d
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@LluisMontoliu
Lluis Montoliu
4 months
Register for the 2025 @ArrigeOrg annual meeting devoted to discuss accessibility and affordability of the novel #CRISPR based gene therapies. In Strasbourg (France) hybrid format, both in-person and online: 28-29 Oct. Free for ARRIGE members. Register at⬇️ https://t.co/e0RiIRdhin
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@LluisMontoliu
Lluis Montoliu
7 months
Today we will celebrate the 4th @ArrigeOrg Albrecht Müller webinar online, this time devoted to #RNAediting in collaboration with @MSCActions #ROPES Starting at 14:00 Paris/CET https://t.co/wyn08ZomcS
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@LluisMontoliu
Lluis Montoliu
8 months
The Montoliu’s lab and @CNB_CSIC @CSIC Mouse Embryo Cryopreservation facility attending the 19th @ISTT_TG #TT2025 meeting at @ETH_en in Zürich (Switzerland). Catching up with many old friends and colleagues in the transgenic animal technologies field. https://t.co/yNGM4ilcYr
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@ArrigeOrg
ARRIGE
8 months
Interested in RNA editing? Then you should attend the 4th Albrecht Müller ARRIGE webinar, on 7 May, at 14:00-17:00 Paris/CET on “Editing RNA or DNA: the great challenge” organized along with @MSCActions #ROPES Participation is free, registration required https://t.co/kS1SVnOZjM
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@ArrigeOrg
ARRIGE
11 months
Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
@juliansavulescu
Julian Savulescu
11 months
Published in Nature - Heritable polygenic editing: the next frontier in genomic medicine?
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@LluisMontoliu
Lluis Montoliu
11 months
@Nature We, from @ArrigeOrg, the association for responsible research and innovation in genome editing, promoting the responsible use of genome editing tools, have also released a statement where we discuss and reject the proposal of heritable polygenic editing. https://t.co/nsx32hBvUI
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@LluisMontoliu
Lluis Montoliu
11 months
Furthermore, potential health benefits and disease resistance traits associated with genetic variants do not strictly correlate with the expected behaviors, rather with certain probabilities. A critical commentary has also been published in @Nature https://t.co/hzUGGm72or
nature.com
Nature - Pitfalls of heritable genome editing undermine theoretical benefits.
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@LluisMontoliu
Lluis Montoliu
11 months
What was wrong in 2018 continues being wrong in 2025. Hence, pretending to edit the human genome at multiple genes only multiplies the risk of unwanted editions at selected locations and elsewhere. It is simply unsafe and reckless to suggest multiple gene editing on human embryos
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@LluisMontoliu
Lluis Montoliu
11 months
In 2018 the irresponsible experiments done by He Jiankui showed the world why it was a bad idea editing one gene on human embryos. Now, a team of Australian scientists led by P. Visscher and J. Savulescu speculates in @Nature on heritable polygenic editing https://t.co/bJ2StuLWp2
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nature.com
Nature - We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the...
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@UoM_GEU
Antony_GEU
11 months
Strong statement on polygenic editing Nature paper from ARRIGE.
@ArrigeOrg
ARRIGE
11 months
Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
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@ArrigeOrg
ARRIGE
11 months
Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
@juliansavulescu
Julian Savulescu
11 months
Published in Nature - Heritable polygenic editing: the next frontier in genomic medicine?
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@LluisMontoliu
Lluis Montoliu
1 year
This follows a previous similar study, where we had the opportunity to participate, describing several resurrected #CRISPR Cas9 nucleases ranging from ~37 through 2.600 My ago. This collaborative study about Cas9 ancestors was published in @NatureMicrobiol https://t.co/Z9XX12hX6Y
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@LluisMontoliu
Lluis Montoliu
1 year
The Raúl Pérez Jiménez lab at @CICbioGUNE did it again, after resurrecting Cas9 ancestors in 2023, @YleniaJabalera et al they just report a new resurrected Cas12a CRISPR nuclease ancestor that could have existed ~3.000 My ago. Published in @NatureBiotech https://t.co/jGukiGR4e5
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nature.com
Nature Biotechnology - ReChb is a Cas12a nuclease with expanded target access and substrate recognition.
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@ruetxe
Jon Rueda Etxebarria
1 year
Thrilled to see the special issue on "CRISPR Trials" at @CRISPRjournal! In addition to many papers of great topicality, you can find our open-access Perspective with @LluisMontoliu and @idemiguelb on the affordability problem of CRISPR therapies. Link👇 https://t.co/Nmv7XrOyTX
liebertpub.com
Casgevy, the world’s first approved CRISPR-based cell therapy, has been priced at $2.2 million per patient. Although this hefty price tag was widely anticipated, the extremely high cost of this and...
@CRISPRjournal
The CRISPR Journal
1 year
The October 2024 issue (anchored by the Urnov guest editorial) is a special issue on "CRISPR Trials": https://t.co/K49OMAWOWV We'll cover all the research, reviews and perspective in subsequent posts.
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