ARRIGE
@ArrigeOrg
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Association for Responsible Research and Innovation in Genome Editing. Towards the responsible use of genome editing technologies. https://t.co/D6W0dqBbFk
Paris, France
Joined March 2018
Our new President Hervé Chneiweiss has prepared this welcome message for ARRIGE members and associated colleagues. It includes his vision for the future of our association. https://t.co/rcLMnGWaC4
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Register for the 2025 @ArrigeOrg annual meeting devoted to discuss accessibility and affordability of the novel #CRISPR based gene therapies. In Strasbourg (France) hybrid format, both in-person and online: 28-29 Oct. Free for ARRIGE members. Register at⬇️ https://t.co/e0RiIRdhin
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Today we will celebrate the 4th @ArrigeOrg Albrecht Müller webinar online, this time devoted to #RNAediting in collaboration with @MSCActions #ROPES Starting at 14:00 Paris/CET https://t.co/wyn08ZomcS
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Interested in RNA editing? Then you should attend the 4th Albrecht Müller ARRIGE webinar, on 7 May, at 14:00-17:00 Paris/CET on “Editing RNA or DNA: the great challenge” organized along with @MSCActions #ROPES Participation is free, registration required https://t.co/kS1SVnOZjM
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Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
Published in Nature - Heritable polygenic editing: the next frontier in genomic medicine?
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@Nature We, from @ArrigeOrg, the association for responsible research and innovation in genome editing, promoting the responsible use of genome editing tools, have also released a statement where we discuss and reject the proposal of heritable polygenic editing. https://t.co/nsx32hBvUI
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Furthermore, potential health benefits and disease resistance traits associated with genetic variants do not strictly correlate with the expected behaviors, rather with certain probabilities. A critical commentary has also been published in @Nature
https://t.co/hzUGGm72or
nature.com
Nature - Pitfalls of heritable genome editing undermine theoretical benefits.
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What was wrong in 2018 continues being wrong in 2025. Hence, pretending to edit the human genome at multiple genes only multiplies the risk of unwanted editions at selected locations and elsewhere. It is simply unsafe and reckless to suggest multiple gene editing on human embryos
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In 2018 the irresponsible experiments done by He Jiankui showed the world why it was a bad idea editing one gene on human embryos. Now, a team of Australian scientists led by P. Visscher and J. Savulescu speculates in @Nature on heritable polygenic editing https://t.co/bJ2StuLWp2
nature.com
Nature - We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the...
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Strong statement on polygenic editing Nature paper from ARRIGE.
Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
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Following the publication of this article by the team of @juliansavulescu in @Nature we have just released a statement on heritable polygenic editing prepared by the ARRIGE Board: ⬇️ https://t.co/eOIQs0lFuZ
Published in Nature - Heritable polygenic editing: the next frontier in genomic medicine?
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This follows a previous similar study, where we had the opportunity to participate, describing several resurrected #CRISPR Cas9 nucleases ranging from ~37 through 2.600 My ago. This collaborative study about Cas9 ancestors was published in @NatureMicrobiol
https://t.co/Z9XX12hX6Y
nature.com
Nature Microbiology - The CRISPR–Cas9 system is widely studied for its role as a phage defence system and for gene editing applications, but its evolutionary origins are poorly understood....
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The Raúl Pérez Jiménez lab at @CICbioGUNE did it again, after resurrecting Cas9 ancestors in 2023, @YleniaJabalera et al they just report a new resurrected Cas12a CRISPR nuclease ancestor that could have existed ~3.000 My ago. Published in @NatureBiotech
https://t.co/jGukiGR4e5
nature.com
Nature Biotechnology - ReChb is a Cas12a nuclease with expanded target access and substrate recognition.
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Thrilled to see the special issue on "CRISPR Trials" at @CRISPRjournal! In addition to many papers of great topicality, you can find our open-access Perspective with @LluisMontoliu and @idemiguelb on the affordability problem of CRISPR therapies. Link👇 https://t.co/Nmv7XrOyTX
liebertpub.com
Casgevy, the world’s first approved CRISPR-based cell therapy, has been priced at $2.2 million per patient. Although this hefty price tag was widely anticipated, the extremely high cost of this and...
The October 2024 issue (anchored by the Urnov guest editorial) is a special issue on "CRISPR Trials": https://t.co/K49OMAWOWV We'll cover all the research, reviews and perspective in subsequent posts.
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The October 2024 issue (anchored by the Urnov guest editorial) is a special issue on "CRISPR Trials": https://t.co/K49OMAWOWV We'll cover all the research, reviews and perspective in subsequent posts.
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I invite you to watch this online webinar which I delivered recently for the students of the @VHIR_ master on "CRISPR Universe: where are we today? From scissors to bridges" where I summarized the current state-of-art of #CRISPR and related technologies. https://t.co/Si192x1U9r
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Sharing a new article, a review on the ethical aspects of geneome alterations (incl. gene editing) approaches applied to animal reproduction research. I will discuss about these issues at the 17th International Conference of #AERA
https://t.co/d61TTglLly
https://t.co/h2nKZtDNOU
pubmed.ncbi.nlm.nih.gov
The revolution in biology triggered by the different genome-editing tools has of course arrived to the research field of animal reproduction. Yeast meganucleases, zinc-finger nucleases, TALEN and,...
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Comparto nuestra última publicación en @CRISPRjournal junto a @idemiguelb y @ruetxe sobre la #accesibilidad y la #asequibilidad y la #equidad de las nuevas terapias #CRISPR que no llegan a todos. Un problema ético que tenemos que resolver ya. #OpenAccess
https://t.co/k414Bk0IGn
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Our last article in @CRISPRjournal on the #accessibility #affordability and #equity for the novel #CRISPR based gene therapies. Therapies are here but are not affordable for many. This is an ethical issue to be solved now. @idemiguelb @ruetxe
#OpenAccess
https://t.co/k414Bk1gvV
liebertpub.com
Casgevy, the world’s first approved CRISPR-based cell therapy, has been priced at $2.2 million per patient. Although this hefty price tag was widely anticipated, the extremely high cost of this and...
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