RT @SimWieg: A thorough and thoughtful summary of the features and limitations of our fused fiber photometry system by @AlexLegariaM @LexKr….

RT @bridge_balance_: Latest paper exploring motivation in obesity and underlying NAc circuits from the @LexKravitz lab! This work was vault….

Also, all the raw data and data analysis pipelines are available at Please feel free to reuse any of the code there.

On a final note, I’d like to give a shout-out to all the peer-reviewers both from the journal and here on twitter. Their feedback was incredibly helpful, and it really reshaped the paper to be what it is now.

Our main conclusion is that fiber photometry should not be interpreted as a proxy for spiking activity, but instead as showing bulk changes in nonsomatic calcium. This opens up big opportunities for and challenges assumptions of the interpretation of fiber photometry experiments.

Surprisingly, we found calcium fiber photometry activity shows a distinct behavior from spiking activity during both spontaneous, and behaviorally-evoked activity. Instead, it reflects primarily nonsomatic changes in calcium.

This wouldn’t have been possible without the invaluable help of co-authors .@bridge_balance_ ., @benyan, @syscarut , @jlicholai .

I’m excited to announce the latest paper from .@LexKravitz . lab in collab with @jones_g_parker lab. Here, we show that calcium fiber photometry in striatum reflects nonsomatic changes in calcium.

Does anyone know of papers that analyze fiber photometry data in other way other than peri-event analysis or counting transients? If so, would you mind sharing refs?.

RT @bridge_balance_: The latest preprint from @LexKravitz lab is here!! We asked how obesity drives changes in NAc circuits and food seekin….

What features would you like to see in a python package for fiber photometry signal processing? I have a module that a few labs have found useful. I'm thinking about refining and expanding it, and to make it public. The emphasis is to make it as simple to use as possible.

RT @_DrOctothorpe_: Reminder from @AlexLegariaM that striatal fiber photometry signals do not reflect somatic firing activity in comparison….

RT @bridge_balance_: Our FED3 paper from @LexKravitz lab just dropped in @eLife!! With co-lead authors @mohamedamrali93 and the Untwittered….

RT @oepsTeam: Our most recent batch of FED3s, churning away during testing!. We'll be presenting @LexKravitz's FED3 at Cool Tools for Scien….

RT @YVachez: .@toodlejess and I are thrilled to post the latest paper from @Meaghan_Creed lab, out today in @NatureNeuro! @cerebellions, @b….

RT @biorxiv_neursci: Fiber photometry does not reflect spiking activity in the striatum #biorxiv_neursci.

RT @jordacular: I knew it! . jk, I thought “well maybe. 🤔”, but awesome for @AlexLegariaM @jlicholai @LexKravitz for doing the hard work….

RT @bridge_balance_: Excited to drop the latest preprint from @LexKravitz lab describing FED3 - a novel home cage compatible device for rod….

RT @leroymwasaru: I am proud to join in the celebration of #OYWDay as a @OneYoungWorld Ambassador, alongside 9,000+ inspiring young leaders….