Alexandra Steigmeyer
@A_Steigmeyer
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@yalechem PhD Candidate | @bostoncollege Biochemistry BS
Joined January 2022
🥳A bit of good news today before the chaos begins (or continues?) -- Our paper was published today @JProteomeRes! Big congrats to @joann_chong along with co-authors @VRAdoesMS, @keira_erol, and @TarynMLucas! Check it out here:
pubs.acs.org
Protein glycosylation is a complex post-translational modification that is generally classified as N- or O-linked. Site-specific analysis of glycopeptides is accomplished with a variety of fragment...
Have you ever wondered how often N- 🟦and O- 🟨glycans modify the same peptide? We did too! Check out our new preprint online now, spearheaded by @joann_chong with help from @VRAdoesMS, @keira_Erol, and @TarynMLucas! 🧵👇
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Thanks to the ECR committee and #HUPO2024 for this honor! 🥂🎉🥳Also, huge congrats to the people who did the work, especially @joann_chong, @A_Steigmeyer, @keira_erol, @mia_rosenfeld! #glycotime #TeamMassSpec Check out the “highlight of the year” here:
nature.com
Nature Communications - Mucin glycoproteins are biologically relevant but are challenging to study. Here, the authors characterized the SmE enzyme and used it to glycoproteomic ally map immune...
@StacyMalaker wins the #HUPO2024 ECR manuscript competition proteomics highlight of the year with her dense mucin O-glycosylation story! Absolute win for #glycotime!
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🥳 New preprint just dropped - thank you to everyone for their help on this, especially @VRAdoesMS!
Have you ever wondered how often N- 🟦and O- 🟨glycans modify the same peptide? We did too! Check out our new preprint online now, spearheaded by @joann_chong with help from @VRAdoesMS, @keira_Erol, and @TarynMLucas! 🧵👇
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WE FINALLY MET HANDSOME DAN!!! And we introduced him to some mucinomics! #glycotime @keira_erol @VRAdoesMS @A_Steigmeyer
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🎉🎉New Malaker lab preprint online now! We improved our mucin-selective enrichment technique to achieve higher throughput, lower sample input, and a higher number of mucins and O-glycopeptides detected! #mucinome #glycotime 🧵👇 https://t.co/CxjuN493Wo
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@StacyMalaker @keira_Erol @joann_chong @A_steigmeyer @miaRosenfeld and colleagues characterize the SmE enzyme and use it to glycoproteomic ally map immune checkpoint proteins. https://t.co/MDl3f7SZIw
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🎉🎉Super excited to announce that our manuscript on T cell immunoglobulin and mucin-domain containing (TIM) proteins was published in @NatureComms! We used glycoproteomics to drive MD simulations and understand how #glycotime affects structure/function: https://t.co/L3KHftWmOb
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Huge congratulations to graduate student @VRAdoesMS on their publication "False-Positive Glycopeptide Identification via In-FAIMS Fragmentation" now out in @JACS_Au!! #TeamMassSpec #glycotime #OpenAccess Check it out here: https://t.co/i84ZtPRqLX
pubs.acs.org
High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates glycopeptides in the gas phase prior to mass spectrometry (MS) analysis, thus offering the potential to analyze glycopepti...
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Heading to #ASMS2023?! Check out Malaker lab posters on Monday and Tuesday from @keira_erol, @VRAdoesMS, @AlixBattison, and @A_Steigmeyer! I'll also be giving a talk on Thursday morning in the glycoproteomics session. 🟨It's #glycotime!!! 🟨
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Malaker Lab posters from @A_Steigmeyer and @VRAdoesMS at @YaleChem Visiting Days!! 🤩🤩Excited to host prospective #chembio grad students today!
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🚨🚨New #mucinome preprint! We used glycoproteomics and MD simulations to understand TIM-3/4 stx/fxn! Buckle up for this wild ride that involved collaborative #glycotime efforts from so many, esp @joann_chong @A_Steigmeyer @keira_erol @mia_rosenfeld 🧵👇 https://t.co/N2u6Bdvb3q
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My lab loves GalNAc, given that its the crux of the #mucinome! But the way we've depicted it is a little bit different... we call her "GlycoGal"! #glycotime
Meet GalNAc, found as the first sugar in O-glycans, you might say GalNAc is mucinous. Seriously though, this member of the #GlycoGang plays important roles from controlling bone density to supporting and controlling our microbiome. It also helps define the A blood type.
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New group photo just dropped! 😀😍 Check out these #glycotime rockstars 🤘👩🎤 @keira_erol @TarynMLucas @AlixBattison @VRAdoesMS @joann_chong @SC_Lowery @A_Steigmeyer @deniz__ince
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New group photo just dropped thanks to Catherine Kwon, summer undergrad with us! Love it so much! @keira_erol @AlixBattison @TarynMLucas @VRAdoesMS @deniz__ince @joann_chong @A_Steigmeyer
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More exciting #mucinome news this week! 🟨🥳Thrilled to share a short Curr Op review summarizing methods to characterize mucin-domain glycoproteins, written by our outstanding undergrad @deniz__ince with support from fantastic postdoc @TarynMLucas:
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THE #MUCINOME HAS FINALLY BEEN REVEALED! Huge thanks to co-first author @riley_nm1, co-authors @ShonJS, @KayvonPedram, Venkat and Oliver, and of course our fearless #glycotime leader @CarolynBertozzi. Out now in @NatComm: https://t.co/Zk9YXXnhQF
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My trainees (Joann pictured, @TarynMLucas and Lexi in the background) are loving Mass Spec Summer School! They're being converted to #TeamMassSpec by leaders in the field. Thanks to @Coon_Labs for hosting and for all of the awesome speakers in attendance!
Mass Spec Summer Schoolers learning manual peptide sequencing. Challenging. And sort of fun. #MassSpecMadison
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