Adrianna San Roman
@AKSanRoman
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Scientist studying mechanisms of sex differences in human biology | Assistant Professor @DukeMGM @DukeCAGT | 🧀 & 🪴 enthusiast | she/her
Joined April 2013
1/ After residency at Mass General Hospital, I reported to Atlanta to meet my fellow CDC Epidemic Intelligence Service Officers. I have never felt so intimidated by my peers The best and the brightest, they were star clinicians, had served in disaster zones; MD/PhDs and MSF.
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Distilling the potential impact of science based on a title is so dangerous. Some of the biggest biomedical breakthroughs came from research that, at first glance, seemed ‘pointless or unrelated. Here are a few that I'm sure might have caused an uproar in the headlines:
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So excited to share some of our work TOMORROW on sex differences in gene expression and disease at #ASHG24! 🧬 👩🔬
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🚨 Online now!! 🚨 @PageLabXY asks: Where is the boundary of the human pseudoautosomal region? https://t.co/JFvPduQ3kN
cell.com
Controversy has arisen regarding a landmark on the human sex chromosomes—the pseudoautosomal boundary—with recent analyses suggesting a location 500 kb distal to that reported in 1989. Our multifac...
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Check out this exciting story from @denniskoHiHOST & @_AngelaJones using the innovative scHi-HOST system to reveal cell-intrinsic mechanisms of sex-biased gene expression. It's been fun thinking about this project together and I'm looking forward to what's next from this team!
What causes differences in biological sex? In our latest preprint, @_AngelaJones takes our lab in a new direction, revealing mechanisms of sex-biased gene expression and identifying abundant sex-biased eQTL throughout the genome (1/6)
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Congratulations @AllyNguyen9!! I am so excited to follow your lab and awesome science!
Thrilled to share I will be joining the Department of Cell and Dev. Bio. @CUAnschutz as an Assistant Professor starting Jan 2025! My lab will investigate the mechanisms that regulate genome integrity and how these processes are rewired across disease, development, and evolution
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My daughter borrowed my "Let's talk preprints" @ASAPbio shirt to wear to sleep at summer camp. She wrote me that her friends are asking about preprints. As my favorite things (my daughters and awesome science) have converged, I wanted to share "what a preprint actually is".
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The "inactive" X chromosome is not so inactive after all — a discovery made by @PageLabXY featured in #STATMadness. We're neck and neck with @UMassChan with 12 hours to go before the first round ends. Consider voting for the Page lab:
statnews.com
Who will be the 2026 MVP of health and medicine? STAT Madness is a bracket-style tournament to find the best innovations in science and medicine from
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Our @CellGenomics paper on the not-so-inactive X chromosome is in the running for #STATMadness! Please vote!
There's still time to vote for @PageLabXY in the first round of #STATmadness, @statnews's competition to find the country's most innovative research institution:
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Our latest paper on the genome-wide impacts of the inactive X and Y chromosomes is now published in @CellGenomics! Thanks to @PageLabXY, collaborators, editors, and reviewers for all of your input along the way! https://t.co/Yk8DTlyelV
cell.com
Using human cells with variation in sex chromosome copy number, San Roman et al. find widespread transcriptomic impacts of the inactive X (Xi) and Y chromosome on autosomes. While Xi elicited larger...
I'm excited to share that a new preprint on work from my postdoc in @PageLabXY is out! I would love to hear your comments, feedback, and questions about this work! 🧵 https://t.co/zt2nYDd1br
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The human Y and inactive X chromosomes similarly modulate autosomal gene expression
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Genes expressed from the X and Y chromosomes impact cells throughout the body—not just in the reproductive system—by dialing up or down the expression of thousands of genes found on other chromosomes. New findings from @PageLabXY: https://t.co/FDV6tcaEsI
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Time is running out to get your applications in for CO-OPT, our #postdoc recruitment event where you get to showcase your #research, explore projects in CAGT and connect with faculty, staff, and current trainees. Learn more and apply today! https://t.co/ges8suzFkI
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I am hiring a research technician for my new lab at Stony Brook University! The lab is new, but we share space with others, allowing to work directly with the PI (me) while having a great larger community in lab. Please share! https://t.co/vcWE6KhnrM
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Thanks @CellGenomics for this shout-out of our recent paper from @PageLabXY! The X chromosome never goes out of style! Using cells with natural variation in X chromosome copy number, we revealed that the not-so-"inactive" X affects expression of the active X.
The human inactive X chromosome modulates expression of the active X chromosome Freely available top-read @CellGenomics paper @AKSanRoman @WhiteheadInst
https://t.co/yO4Vimh8Od
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The human inactive X chromosome modulates expression of the active X chromosome Freely available top-read @CellGenomics paper @AKSanRoman @WhiteheadInst
https://t.co/z7pcMdwjGw
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Come join us in the Maldonado lab! I'm recruiting a postdoc to work on structure/function of electron transport chain complexes of under-studied photosynthetic organisms using cryoEM and biochemistry. Ad below, happy to answer informal questions! https://t.co/tFZYun2Rha
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