Ally_Nguyen
@AllyNguyen9
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Assistant Prof. @CUAnschutz. Interested in genome integrity and how core cellular processes are rewired in disease, development, and evolution. views are my own
Joined July 2018
Thrilled to join the amazing Boettcher community and be named a 2025 Boettcher Webb-Waring Investigator! @BoettcherFdn @CUAnschutz
These seven outstanding early-career scientists represent the next generation of scientific excellence in Colorado, marking another milestone in our 16-year commitment to strengthening the state’s biomedical research ecosystem. Welcome, Investigators!
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Really nice write-up on mine and @JustinKOHare research that was recently awarded the highly competitive @klingensteinorg neuroscience awards. Thank you @CUMedicalSchool for the shout out! And @CUPharmacology for providing such an exciting scientific environment for #newPI
Debosmita Sardar, PhD, and Justin O’Hare (@JustinKOHare), PhD, two pharmacology researchers from the CU School of Medicine, through the Klingenstein Fellowship Awards in Neuroscience, were awarded $450,000 for their projects ⬇️ https://t.co/w5yswNBTfI
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New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? https://t.co/2CCq7AgYWS
biorxiv.org
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These...
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Debosmita Sardar, PhD, and Justin O’Hare, PhD, Assistant Professors in the Department of Pharmacology, have received Klingenstein Fellowships in Neuroscience, one of the nation’s most prestigious awards for early career scientists. Their high-risk, high-reward research explores
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1/ I'd like to share a major part of my postdoctoral work, co-mentored by Rudolf Jaenisch and @youngricka, and a major collaboration with @MeWantData @CorradinLab, all at @MIT @MITBiology and @WhiteheadInst.
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New pre-print! Ryan Kim et al distinguish the roles of the Spindle Assembly Checkpoint as a surveillance pathway only triggered by mitotic errors vs a mitotic timer that is required in every cell division. https://t.co/Rj8mfBx8Hd
biorxiv.org
The Spindle Assembly Checkpoint (SAC) plays critical roles in regulating mitotic fidelity and progression. Here, we utilized a SAC-deficient cell line lacking the full-length Cdc20 translational...
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Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a tweetorial today, but enjoy and happy to get any feedback on this story. https://t.co/vkbL8m7YFG
biorxiv.org
Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote...
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Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10_d): Brieflow. A game changer for OPS + new biological insights https://t.co/H3BATSipjF
biorxiv.org
Optical pooled screening (OPS) has emerged as a powerful technique for functional genomics, enabling researchers to link genetic perturbations with complex cellular morphological phenotypes at...
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Optical pooled screening is revolutionizing functional genomics by linking genetic perturbations to complex cellular phenotypes at unprecedented scale. But analyzing these massive datasets has been a major bottleneck - researchers face fragmented tools, multiple format
Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10_d): Brieflow. A game changer for OPS + new biological insights https://t.co/H3BATSipjF
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Delighted to share our updated work, led by postdoctoral fellow Dr. Maria Campaña, published in @NatureComms: https://t.co/pX0ebHhkiM, PDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation
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My lab is hiring a research assistant to work on 3D genome architecture in frog embryos. Please spread the word! #xenopus #chromatin 🐸 🧬🔬
employment.ku.edu
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First official Nguyen Lab photo! Welcome to the team Molly and Michael! 🔬Check out what we are working on at https://t.co/ZeBbETGwgo
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🚀 Exciting news for early-career researchers! The new Max Planck #Postdoc Program offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. Applications are open now! https://t.co/mU5NBXMsDU
#ScienceCareer #PostdocProgram
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New preprint countdown! Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected strategy with ancient origins. Stay tuned!
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We are hiring! Looking for a Research Assistant to join our group at CU Anschutz in Denver studying genome integrity https://t.co/qbLhP5bNcY. Individuals will lead their own project as well as help support basic lab function!
nguyenlab.org
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Trying to focus on the small positives given all the chaos. For example, today the Nguyen lab got our first package! Ready to do some kick ass science 💪
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The unprecedented cuts that have taken place to research will cripple science in America. This affects ALL Americans, risking our collective health, safety, and national security. Please reach out to your local gov. Representatives and stress the importance of STEM in the USA!!
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Researchers in the Cheeseman lab have identified an important molecular switch that induces a distinct pattern of protein variant production during mitosis. #ResearchHighlights
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Pavana Rotti, who studies the neurobiology of opioid use disorder, discusses her work-life balance as both a parent and a postdoc. https://t.co/iYcJT6mvtg
#WhiteheadPostdocProfiles
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