Dear @sethmoulton, please fund global vaccine programs at the highest levels for FY23. #COVID19 has shown us how critical it is to invest in vaccines that protect against diseases and to strengthen global health systems so that children everywhere can get a @ShotAtLife.

Dear @senwarren, please fund global vaccine programs at the highest levels for FY23. #COVID19 has shown us how critical it is to invest in vaccines that protect against diseases and to strengthen global health systems so that children everywhere can get a @ShotAtLife.

Dear @SenMarkey, please fund global vaccine programs at the highest levels for FY23. #COVID19 has shown us how critical it is to invest in vaccines that protect against diseases and to strengthen global health systems so that children everywhere can get a @ShotAtLife.

The first ever @RockLabTB research paper is out in @CellCellPress https://t.co/FGVQZbQ8ZL A herculean effort co-led by PhD student Barbara Bosch & bioinformatician Michael A. DeJesus. Here’s a summary of our quest to identify the (genetic) Achilles’ heel(s) of M. #tuberculosis.

In a new study, I identify and recover a deleted set of #SARSCoV2 sequences that provide additional information about viruses from the early Wuhan outbreak: https://t.co/1zdeiOQ0vo (1/n)

New Cell Resource! Single-cell atlas of human #oral #mucosa connects inflammatory signatures in #epithelial & #stromal cells w/ #neutrophil infiltration in #periodontitis & identifies cell-specific expression patterns of periodontitis susceptibility genes

The new issue is out! In this Special Issue, we explore ways in which #biological systems adapt to #uncertainties, #stress, and #change and highlight how biological #research is helping chart a path through the #unknown toward a better future for all https://t.co/0VOkegH3Sc

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

The antigenic anatomy of SARS-CoV-2 receptor binding domain: Cell

New Cell Paper: Analysis of human serum before & after the #COVID19 pandemic started show that antibodies against common seasonal hCoVs are cross-reactive against #SARSCoV2 but do not cross-protect against infection or hospitalization

New Cell Paper! Commensal #fungi in the human gut shape #antibody responses in the blood to protect the host from systemic lethal fungal infections.

New Cell resource! Single cell analysis of #COVID19 patient #immune landscape in #lung & peripheral blood. Reveals #SARSCoV2 RNAs in diverse cell types. Highlights the potential contribution of #megakaryocytes and #monocyte subsets to cytokine storms.

New #COVID19 paper at Cell! The B cell response against #SARSCov2 shows a temporal shift: (1st) an extra-follicular reaction that includes memory B cells against seasonal CoVs to >>> (2nd) a GC-dependent memory response encoding neutralizing antibodies

Now online at Cell: Public health guidance for increased surveillance and measures to reduce community transmission, as #SARSCoV2 genetic #variants quickly spread.

New Cell Paper! #N439K #SARSCoV2 spike mutation: similar viral fitness compared to wild-type, BUT resistant to some neutralizing monoclonal antibodies and reduces effect of some polyclonal antibody responses

New Cell paper! The dural sinuses are a #neuroimmune interface, where patrolling T cells survey brain- and #CSF-derived antigens to enable #CNS #immune surveillance. This niche is altered during #aging & #neuroinflammation - could be a Tx target

New Cell paper - Cell-cycle-dependent #recombinase-like activity of #EBNA1 is required for #replication termination and viral episome maintenance of oncogenic #EpsteinBarrvirus. #EBV Paul Lieberman Lab @TheWistar

Nice new Cell Perspective from @RMedzhitov: "Food allergy as a biological food quality control system" - Part of our upcoming 2021 Special Review Issue (March 18th)

New Cell paper: Wang et al. show atopic #dermatitis-associated #inflammation promotes a #basophil-leukotriene #neuroimmune axis to evoke acute #itch flares.