vosslab
@voss_lab
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Biochemistry/cell biology research group @kieluni | proteolytic processing of Golgi enzymes and Golgi organisation | PI tweeting | now mainly at bsky
Kiel, Germany
Joined February 2022
RT @_WolfLab: Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Ch….
academic.oup.com
Abstract. Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses to environmental changes. It is therefore no surprise t
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RT @DammeMarkus: Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! h….
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RT @J_Cell_Sci: Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology sur….
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RT @embojournal: Our final 2024 issue!.Highlight: New players in lysosomal sorting via mannose-6-phosphate.mRNA deadenylation & decay relat….
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Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion.
onlinelibrary.wiley.com
Tumor and immune cells interact through receptor–ligand interactions. B3GNT5 produces nsGSL on tumor cells which is regulated by SPPL3. When SPPL3 is absent, elevated nsGSL levels hinder receptor–l...
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RT @LysoProteomics: Great collaboration with the @voss_lab out now in EMBO Journal! Congratulations Matthias for this nice work!.
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RT @_WolfLab: Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Man….
pubmed.ncbi.nlm.nih.gov
The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized...
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RT @embojournal: GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway.Sabrina Jab….
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RT @cell_club: GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Jo….
embopress.org
imageimageLYSET, a Golgi protein essential for mannose 6-phosphate (M6P) tagging, is destabilized in cells lacking the COPI adapters GOLPH3/3 L. This study shows that the LYSET-GOLPH3/3 L interaction...
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Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging.
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New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3
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RT @DammeMarkus: I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD studen….
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RT @SekineTak: Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣️.
ki.varbi.com
Vill du bidra till en bättre hälsa för alla? Sekine-gruppen söker en motiverad forskningsassistent för laborativ- och teknisk support. Vår forskning fokuserar på att karakterisera mekanismerna
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Exciting and comprehensive paper - and notably another study that underscores the physiological relevance of SPPL3.
Our resource on NK cell - cancer interactions is now out in @ImmunityCP. We identify tumor-induced NK cell states at single-cell resolution and tumor-intrinsic resistance mechanisms using CRISPR functional genomics. Explore: 1/
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Congratulations to Neele and Stefan on their recent paper in BBA Mol Cell Res, glad we could contribute
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Preprint with exciting #SPPL3 #glycotime results from Eric Long’s lab (glad we could contribute to this): Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
biorxiv.org
Somatic mutations can lead to the transformation of healthy cells into malignant cells and allow their evasion from immune surveillance. To uncover genes that play a role in the detection and lysis...
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