Excited to share the first article from our lab @NatImmunol Kudos to Drs. Abraham and Samaniego-Castruita for leading the studies. This work wouldn’t be possible without our amazing colleagues @NU_CDB, @immunology_nu, @LurieCancer, @NUFeinbergMed 1/n 🧵

Thank you @immunology_nu for highlighting this. This wouldn't have been possible without the generous support of my amazing colleagues @NUFeinbergMed @immunology_nu and @NU_CDB and importantly, all members of our young and curious lab!.

Our Department is Hiring for a Tenure-track Faculty position. Outstanding interdisciplinary science, great colleagues, and an amazing city. Look no further! And please reach out if you have any questions.

RT @PengJi_lab: Interested in the mechanisms of DDX41 in the pathogenesis of myeloid neoplasm? Read our preprint at .

Thank you @ImmunoSketch, for this super cool illustration of our work! For those interested, our full story can be accessed here: @LurieCancer @NU_CDB @NUFeinbergMed @NatImmunol @immunology_nu.

If you are looking for a terrific work environment, look no further!.

Thank you, @NCICancerBio, for supporting this work. As a trainee, it was an amazing feeling and an important milestone to get my ideas validated through a K99/R00 award. Looking forward to where the science takes us next. Support #Science.

We also want to congratulate @edeon, @LabMelnick and @GreenLymphoLab for their amazing work in understanding the the tumor suppressive roles of BAF complexes in B cell lymphomas which was published just few months ago. science builds on science!.

A press release about our work from Olivia Dimmer @NUFeinbergMed. Here, Drs. @ajayabrams and Daniela Samaniego-Castruita share their thoughts on the key findings from the work. Thank you @LurieCancer @NU_CDB @immunology_nu for supporting our trainees!.

Thank you @LurieCancer for supporting our work. Our full article can be accessed here:

@AshimaBhakri @AnjanaRaoLab @mliarispe @StephanieEisen @basulabcolumbia Lastly, as a new PI, I had to overcome a lot of “self-inflicted (self-)doubt” every single day. I never expected this to be the first paper from our lab. I guess science plays out in its own mysterious ways and my two cents are to remember that you are not doing this alone!! 10/n.

Thank you @AshimaBhakri for collaborating on this project. Thank you @AnjanaRaoLab @mliarispe @StephanieEisen @basulabcolumbia and Dr. David Schatz for your mentorship through the years. Special mention to all members of our relatively new lab to keep inspiring me every day 9/n.

Since several subunits of different BAF complexes are frequently mutated in cancers, the inflammatory signatures uncovered by our studies here may be relevant to pathogenesis of cancers with BAF loss-of-function mutations. Surely more to come, as we follow up on this work 8/n.

Our studies add to an emerging paradigm, where unrestrained inflammation appears to dictate the quality of the adaptive immune response. Such a feedback mechanism might be useful to prevent the breakdown of immune tolerance and autoimmunity in highly inflamed tissues 7/n.

Importantly, dampening of the inflammatory signals either by IL1b blockade or treatment with Dexamethasone, an anti-inflammatory glucocorticoid receptor agonist, led to a partial but clear rescue of germinal center responses in Arid1a-deficient mice 6/n.

A fascinating vignette: the inflammatory programs turned on in absence of Arid1a is associated with loose nucleosomal packing near transcription start sites, suggestive of changes in nucleosomal positioning potentially driven by altered histone modifications 5/n.

A surprising finding was a strong induction of inflammatory signals in B cells lacking Arid1a. Unlike the well-known functions of BAFs as positive regulators of gene expression, this suggested a role of Arid1a-BAF complex in suppressing inflammatory gene programs 4/n.

Similar to known functions of BAF in creating open chromatin landscapes, we noted that the Arid1a-BAF complex collaborates with several transcription factors of ETS, EBF and E2A family to establish chromatin accessibility at thousands of regions during B cell activation 3/n.

In this work we investigated the role of the canonical BAF complex (a.k.a. SWI/SNF @swisnf) in generation of humoral immune responses. We discovered that the Arid1a-dependent BAF complex is indispensable for production of high-quality antibodies in the germinal centers 2/n

Congratulations, @StephanieEisen, for this honor from AAI. Thank you for all the amazing discoveries that are moving the field forward in a profound way. You are such an inspiration, an integral part of the research community and an awesome mentor to me and many others.