Vennetilab
@vennetilab
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The Venneti lab's goal is to develop cures for DIPGs and childhood ependymomas.
Ann Arbor, MI
Joined August 2020
Very excited to share our work on metabolic and epigenetic treatments for DIPG. https://t.co/Kvj3sL61b8
@chadtough
#dipg @chadtough @sontagfoundation #defeatDIPG @AlexsLemonade @tamcarr21
cell.com
Chung et al. show that H3.3K27M mutation in DIPGs enhances glycolysis and TCA cycle metabolism to produce α-KG that is required to maintain a preferred epigenetic state of low H3K27me3. Inhibiting...
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I’m a western blot ladder for Halloween! Can’t get more nerdy than this!!
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Online Now: Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis
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Amazing talk on mechanical stresses on medulloblastoma metastasis by @XiHuang18 at #pedsno2025
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We are delighted to share our new study on metabolic dependencies in group-3 medulloblastoma! Thanks to an awesome team of collaborators who made this possible! @LyssiotisLab @YatrikShahLab @sontagfdn @CarlKoschmann @SophiaLunt @UMRogelCancer @UMichPath
https://t.co/DJRA6U7jP6
cell.com
Dang et al. report that group-3 medulloblastomas (MBs) show c-MYC-driven high DLAT expression. In these tumors, wild-type IDH1 epigenetically regulates c-MYC, and inhibiting IDH1 lowers c-MYC and...
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Very proud of @_JoannaLum talking about her @chadtough funded work on #DIPG at our annual @UMichPath symposium.
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Sharing Amazing work on metabolic targeting of OPC and AC-like H3K27M DMG cells from former postdoc @mbah_nneka from @LyssiotisLab in collaboration with @vennetilab and many other labs! https://t.co/4nYtyLjoyx
nature.com
Nature Communications - Pediatric brain cancers are lethal malignancies driven by less-differentiated stem-like cells. Here the authors show that these cells exhibit distinct mitochondrial...
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Star graduate student @DanaDoesScience from @KoschmannLab presenting at the cancer bio retreat! @CarlKoschmann @lyssiotis
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Help us turn the map orange in honor of Chad’s 14th bday. 3 registrations per state turns the state orange! Sign up to run, walk or just wear the shirt & help us to defeat DIPG. Love seeing the awareness about ChadTough growing. Thank you! 🧡 Register at https://t.co/QktTw2Jgs0.
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Beautiful work discovering neuronal regulation of #ependymoma through histone serotonylation by the Twitter-less Ben Deneen! #CancerNeuroscience
https://t.co/kknjv6UcdE
nature.com
Nature - Serotonin has a role in ependymoma tumorigenesis through modifying histones and thereby regulating key transcription factors and activating specific oncogenic transcriptional networks in...
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Stellar presentation from the star undergraduate student of @vennetilab, Ruhi Gulati at the CARSIP symposium today! #proudmentor 🥹😊Huge thanks to the @UMRogelCancer for the support and in nurturing such brilliant minds 🙌🏼
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Members of our Neuropathology team attended & presented on numerous topics at the 100th annual meeting of @neuropathology last week. #AANP100 Virginia Man-Yee Lee, PhD also received the Award for Meritorious Contributions to Neuropathology, congrats!! @MacNasrallah @TNRLab
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Penn Neuropath alumni and current folks respresenting at #AANP100 with the amazing @TNRLab and @jasonhuse! Such an honor to be a part of the 100th anniversary of @neuropathology!!
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Day 3 of our lab retreat! So grateful to work with amazingly smart and dedicated team!!
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