Jacqueline Tabler
@tablerlab
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Developmental biologist using live imaging to understand how the skull grows around the brain. @mpicbg
Dresden Germany
Joined June 2018
Fundamentally, our work demonstrates that mechanisms driving motion in other physical contexts such as gasses, also extend to dynamics generated at the scale of tissues.
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Our work suggests that the slope of a stiffness gradient, not just the absolute tissue stiffnesses, can tune the rate of morphogenesis in vivo.
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We developed a novel biophysical model that provides a simple framework to understand how feedback between stiffness-induced differentiation and cell motility generates can self-propagating wave that expands at a speed set by the stiffness gradient across the tissue.
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Our main findings: - We find a novel mechanism to drive collective motion DOWN a stiffness gradient. Therefore, our work demonstrates an entirely new alternate mechanism for stiffness-mediated collective mesenchymal motility in vivo.
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Super excited to share with y'all a new mechanism for collective motility in living tissues which can learn about in our latest preprint.🎉 Check it out! https://t.co/CO3Cyt2eBi
biorxiv.org
Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply...
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New collaboration with the @tablerlab & @florianjug out on Biorxiv https://t.co/K5tK1Ah2by Check out @Diana_Afonso_ & @allyQryan ‘s remarkable work demonstrating the need for higher order shape and topology descriptors in a mesoscale tissue niche - the suture @mpicbg @csbdresden
biorxiv.org
Balancing self-renewal and differentiation is a key feature of every stem cell niche and one that is tuned by mechanical interactions of cells with their neighbors and surrounding extracellular...
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Don't forget to register https://t.co/GR3GBsIBdA for the 2nd "Advances in Craniosynostosis" conference, next Friday. Great programme, including @jtr505 @rkraftComputes @kilcoyne_sarah @Wilkie_Lab @tablerlab @moazenlab - @HeadlinesCranio @uclmecheng @Health_Eng #craniosynostosis
Don't forget to register https://t.co/559iA1wbLQ for the 2nd "Advances in Craniosynostosis" conference, next Friday. Great programme, including @jtr505 @mehran_moazen @Wilkie_Lab @OxfordCranio @rkraftComputes Optional donations to Headlines: https://t.co/WXny8W5vU1
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So good to science with these guys
#lockdown has slowed time so much I went backwards six years! Zoom lab meeting with postdoc alums @ksedzinski, @tablerlab, and @Asakos01. More, more, morphogenesis! Thanks, guys, for the lovely chat.
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The call for a joint @mpicbg & @PoLDresden @tudresden_de junior research group leader on tissue organization and dynamics is still open until January 31. Apply now! We are looking forward to your application!
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New on the Node: Understanding Birth Defects in the Genomic Age @ashishdeshwar & @nicoleedwds give an early career perspective on the recent @Co_Biologists Workshop https://t.co/JQESdhkd5i
thenode.biologists.com
By Ashish Deshwar and Nicole Edwards Two weeks ago, we had the opportunity to attend the Company of Biologists Workshop, “Understanding Birth Defects in
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Check out our work on how to facilitate optical access to apical and lateral membranes of polarized tissue in 2D and 3D cell culture with super-resolution #STED. https://t.co/63T4XHMwbE Movie shows 3D render of apical microvilli on MDCK cells #Polarity #Microscopy
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Our latest preprint: Self-organised symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation by @viktri08 @TimFulton_1 @andattardi Kerim Anlas @dd_chaitanya @AMartinezArias @BenSteventon2 @GeneticsCam @emblbarcelona
https://t.co/V8vXorSfwH
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So cute
This beauty, phyllium philippinicum reached Adult last week, look at those beautiful wings and how they mimic a leaf to such detail. Despite the wings this species can’t fly. The wings lack underwings which are essential for flight.
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A fantastic opportunity for those looking for an interdisciplinary postdoc !
One more week to apply! Deadline to join the interdisciplinary #ELBE Postdoctoral Fellows Program @csbdresden is 12 September. Work with us at the intersection of computer science, physics, and biology! 💻📚🔬 @mpicbg @tudresden_de #MPIPKS
https://t.co/bbYrAcdcGH
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Spotted outside a hospital in Qatar! An incredible architecture
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Woot woot woot! It works!
The moment of truth - first explant #CRISPR results with @tablerlab @Diana_Afonso_ @andattardi #EMBOmousegenome
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Excited about this week's experiments..!
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John Wallingford...The 200-year effort to see the embryo
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