Stefani Spranger
@stefanispranger
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Torres-Mejia et al. showed that tumor cell-intrinsic SOX2 expression correlated with low T cell infiltration in NSCLC. https://t.co/TGm4xN8WCs @kochinstitute @stefanispranger
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A new Science #Immunology Review discusses the mechanisms through which #DendriticCells influence cytotoxic CD8+ #TCell responses against cancer. @viditbhandarkar @stefanispranger
https://t.co/NYhIEnOOMv
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Review @SciImmunology @viditbhandarkar @stefanispranger DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer https://t.co/CoMnWn1WiC
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@SciImmunology @kochinstitute @MITBiology This was written by two talented grad students @viditbhandarkar and Teresa Dinter, both will be graduating this year and looking for new adventures!
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Check out the new review from the groups on how DC shape anti-tumor immunity. We focus on the lymph node interaction as well as the restimulation of T cells in the tumor! https://t.co/IL3hIa2IIM
science.org
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.
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Meet the Author: Malte Roerden (@RoerdenM), a physician-scientist from @kochinstitute, is 1st author of “Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression,” recently published in #JITC! 1/6
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Looking forward to the visit!
The Program in Immunology welcomes Dr. Stefani Spranger @stefanispranger from @MITBiology and @kochinstitute. Please join us for her seminar on Monday January 13!
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Would love to see many of you at #KSCancerImmune25 at Fairmont Banff Springs, I am co-organizing together with @stefanispranger & Christian Blank, held jointly with Immune Cell Therapies. https://t.co/eYpswxludN
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How different immune evasion mechanisms interfere with immunoediting of evolving tumors - @RoerdenM
@stefanispranger @NatRevImmunol
https://t.co/43Lj5IGoB6
#Cancer #ImmuneOnc #IO #ImmunoOncology #Immunotherapy #MedEd #MedX #MedNews #Health #Medicine #OncoDaily #Oncology
oncodaily.com
Malte Roerden: How different immune evasion mechanisms interfere with immunoediting of evolving tumors / cancer, cancer immune evasion, immunoediting,
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Very excited to share our recent work now published in @NatRevImmunol! We reviewed how immune evasion mechanisms interfere with immunoediting to fosters intratumor heterogeneity (ITH) and discuss data on the role of ITH itself in blunting anti-tumor immunity. @stefanispranger
Cancer immune evasion, immunoediting and intratumour heterogeneity
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This is followed by a review written together with @RoerdenM on immune evasion mechanism published in @NatRevImmunol
nature.com
Nature Reviews Immunology - Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour clonality. They suggest...
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In short she showed how tumor cell-intrinsic Sox2 expression mediates T cell exclusion by recruiting regulatory T cells to the tumor margin
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Way to start the new year! Read here the latest story from the lab by postdoc Elen Torres.
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Thank you @jitcancer for the nice summary! It shows nicely how different combinations of cross-presented antigens affect anti-tumor immunity and immune evasion.
Here’s a closer look at #JITC article: “Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression” by authors @RoerdenM @stefanispranger from @kochinstitute 1/11
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So fun to have Scott Lowe @LoweLabMSKCC visit @kochinstitute for our 50th anniversary seminar series.
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New #JITC article: Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression https://t.co/6wpiAZEsVT
@RoerdenM @kevlitchfield @stefanispranger #SITC24
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It was great to have Kay MacLeod here at the @kochinstitute and @ScienceMIT today as part of our 50th anniversary of the cancer center! Kay was @LabJacks first postdoc in 1993 and is now professor @UofC Cancer center!
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👏Congrats to @RSNA resident grant awardees 🔥@AmyWisdom8 for novel #glioblastoma mouse models @stefanispranger @kochinstitute @MIT 🔥@BanlaIsmael for novel radiation induced payload releases @DrWilliamHwang @MGH_RI @broadinstitute Excited for what you will accomplish‼️
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BSG-MSRP-Bio student Yeongseo Son breathed new life into her love of science over a summer of studying immune responses in the lungs in the Spranger Lab @stefanispranger
biology.mit.edu
BSG-MSRP-Bio student Yeongseo Son breathed new life into her love of science over the summer in the Spranger Lab studying immune responses in the lung in the Department of Biology at MIT. When...
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