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@simon_sprecher

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Professor in Neurobiology at University of Fribourg @unifr @unifrBiology bringing #neurogenetics from #Drosophila to #Cephalopods and #Cnidaria -View are my own

Fribourg, Switzerland
Joined May 2012
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@simon_sprecher
simon-sprecher.bsky.social
1 month
Now published: .
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elifesciences.org
The dopamine receptor Dop1R2 plays a crucial role in the formation of longer-lasting memories, while it is dispensable for short-term memories.
@simon_sprecher
simon-sprecher.bsky.social
1 year
Dopamine is doing many jobs in our brains! .One way that neurons can can distinguish what Dopamine as "signal" means are the Receptor proteins that detect Dopamine- .
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@simon_sprecher
simon-sprecher.bsky.social
2 months
Excited to announce that the preliminary program for the Cephalopod Neuroscience GRC is now online! .Applications are now open! Attendance is limited so be sure to register early in case space fills up!.
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@simon_sprecher
simon-sprecher.bsky.social
2 months
RT @thecocodium: I am looking for a new postdoc to join the lab. Interested in pluripotency, germ cells, and in investigating these in a ge….
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@simon_sprecher
simon-sprecher.bsky.social
2 months
Officially starting a joint project with @SeuntjensLab and Oleg Simakov lab- studying the link between genomes, gene expression and cell type diversity in #Cephalopod brains! .Open positions to apply-.Please RT!
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@simon_sprecher
simon-sprecher.bsky.social
5 months
We have open PhD positions in the lab to work in the Neuroscience of #Cephalopods and #Drosophila-.please RT
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@simon_sprecher
simon-sprecher.bsky.social
7 months
RT @SwissDementia: Welcome @simon_sprecher to our association!🧠 At @unifr, Simon’s lab uses genomics & AI to uncover dementia's genetic roo….
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@simon_sprecher
simon-sprecher.bsky.social
9 months
One day on Bluesky and the feed is busy- you’ll find virtually everything you get on Twitter/X see you on the other side .
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@simon_sprecher
simon-sprecher.bsky.social
9 months
RT @JM_Gahan: Happy to share that the Gahan lab will be branching out (or more like returning) to working on Nematostella in the near futur….
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@simon_sprecher
simon-sprecher.bsky.social
11 months
Yep!!! One of these weeks….
@whataweekhuh
What a week, huh? all Wednesdays
11 months
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@simon_sprecher
simon-sprecher.bsky.social
1 year
RT @unifrBiology: This year, the Department of Biology @unifrBiology will support outstanding young scientists who.aim to apply for the S….
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@simon_sprecher
simon-sprecher.bsky.social
1 year
never doubt the capacity of molecular reagents!!! ;-).
@alon_douek
Dr Alon Douek
1 year
@ATinyGreenCell Used this bad boy today, worked perfectly (even in ‘adverse’ reaction conditions!). Honestly not sure what the basis for these expiry dates are but NEB enzymes are unquestionably stupidly good quality 😂
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Wow- blows my mind… very cool!.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Lead by @Neuro_komarov in collaboration with @BartDeplancke and Jae Young Kwon.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Investigating the role of sensory receptor genes, we show that C7 depends on Gr21a/Gr63a for CO2 sensing, while these receptors are dispensable for sucrose or mechanical perception. Thus the gustatory neurons already integrate the breadth of sensory experience during eating.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
- Using genetically encoded Calcium sensors we show that certain gustatory neurons are in fact responding to both chemical as well as mechanical stimulation. -We identify one a sucrose-sensitive / mechanosensitve neuron as the previously described C7- neuron.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
The gustatory organ-specific split-Gal4 showed that beside taste coding, also mechanical cues are sensed by the gustatory organs. Indeed, in the single-cell data we observe expression of genes involved in mechanosensation.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Using a custom-made single-cell transcriptomics approach we characterize the taste and olfactory organs;.- Based on the single-cell data we created a genetic tool (Split-Gal4) that uniquely covers gustatory- organs in the fruit fly (comparable to Orco for the study of olfaction).
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Here we show that there are sensory neurons that perceive both chemical and mechanical stimulation. We use the fruit fly larva as genetic model and identify multisensory "gustatory receptor" neurons- a completely novel and suprising tuning of sensory cells.
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@simon_sprecher
simon-sprecher.bsky.social
1 year
Eating is a multisensory experience- we do not simply "taste" the food we enjoy, we also take into account its texture and visual appeal!.What about the food texture? We know very little about this part of the eating experience- .
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biorxiv.org
Food presents a multisensory experience, with visual, taste, and olfactory cues being important in allowing an animal to determine the safety and nutritional value of a given substance[1][1]....
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@simon_sprecher
simon-sprecher.bsky.social
1 year
How did brains/CNS evolve and how do they compare in early diverging bilaterians?.The nervous system of Xenacoelomorpha are an important proxy, to understand neurogenesis to behavior! .Here an update on recent advances, thanks to Pedro to pushing this forward!!!.
@martinezserrap1
Pedro Martinez
1 year
Here our latest, a thorough description of the state of the (key) field of “Acoel Neurobiology” With @simon_sprecher , @bailly43410630 and Volker Hartenstein.
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