SilcsBio
@silcsbio
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SilcsBio provides software and services for unlocking the full potential of computer-driven drug design.
Baltimore, MD
Joined April 2018
Run CGenFF for Just $1 per Molecule (July Only). Industry users can now generate topology and parameters for small molecules for just $1 each. Explore #CGenFF with minimal commitment and maximum flexibility. #CompChem #MolecularModeling.
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RT @ML_Chem: Harnessing computational technologies to facilitate antibody–drug conjugate development #machinelearning #compchem
https://t.c….
nature.com
Nature Chemical Biology - The development of antibody–drug conjugates remains a challenge in part due to the lack of three-dimensional structural information that must account for the...
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RT @alex_mackerell: Beyond on overview of physics and ML-based methods applied to antibody-drug conjugates (ADCs) the paper presents calcul….
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New Perspective in Nature Chemical Biology: physics-based computational methods like MD and SILCS enable predictive, rapid design of ADCs—optimizing linker–site–DAR choices & payload–antibody interactions. #ADC #Biologics #CompChem #SILCS @alex_mackerell
nature.com
Nature Chemical Biology - The development of antibody–drug conjugates remains a challenge in part due to the lack of three-dimensional structural information that must account for the...
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KRAS G12D: Once Undruggable, Now Predictable with SILCS. See how our platform delivers:.🔹 Binding site ID from apo structures.🔹 Accurate pose refinement + LGFE scoring.🔹 Atom-level SAR insights. #CompChem #DrugDesign #SILCS .
silcsbio.com
High-throughput, physics-based simulations delivering near-FEP accuracy, interpretability, and speed — a retrospective study on the challenging KRAS G12D target. KRAS mutations—especially the G12D...
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SilcsBio Team will be at #ACSSpring2025. 🎤 #Talk by @AsukaOrr : SILCS for ADC development.📅 Sun, Mar 23 | ⏰ 4:30 - 4:55 PM. 📜 #Poster by @aakognole : Speed vs. Accuracy in CADD.📅 Tue, Mar 25 | ⏰ 7:00 - 9:00 PM |📌# 865 . 📍Booth at #ACSExpo # 3951. #CompChem #DrugDesign.
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ACS Spring 2025 is just two weeks away! The SilcsBio team will be in San Diego!. We’ll be at the ✅ Expo with a booth, plus we have a✅ talk and a ✅ poster session lined up. Stay tuned for details on our schedule. If you’re attending, let’s connect! 👥 #CompChem #ACSSpring2025.
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SILCS v2025 Release Webinar Recording is Now Available! 🎬. Missed the live session? Catch up now to explore📺:. 📄 Read full release notes: #CompChem #drugdesign.
silcsbio.com
We recently hosted our SILCS v2025 Release Webinar, showcasing the latest advancements in our cutting-edge molecular modeling platform. If you missed it, now’s your chance to catch up! SILCS v2025...
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Reminder to register! SILCS v2025 will be available starting next week. Join us to take an in-depth look.
🌟 Join Us for the SILCS v2025 Release Webinar! 🌟. Key Highlights being coverd:.- Precise docking w/ water inclusion.- Improved ML-based hotspot ranking.- Streamlined multi-cofactor simulations. 📅 Feb 13, 2025, 12 PM ET.Register: . #compchem #drugdesign.
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🌟 Join Us for the SILCS v2025 Release Webinar! 🌟. Key Highlights being coverd:.- Precise docking w/ water inclusion.- Improved ML-based hotspot ranking.- Streamlined multi-cofactor simulations. 📅 Feb 13, 2025, 12 PM ET.Register: . #compchem #drugdesign.
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🎥 Missed the SILCS-WATER webinar? Watch the recording now!. Learn how SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions. 📽️ . Thanks to @anmol_aaryan and @alex_mackerell . #CompChem #DrugDesign.
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🚀 Beta Testers Wanted for SILCS-Covalent!. We've developed a new covalent workflow module to enhance drug discovery. Check out our publication: Interested? Reach out at info@silcsbio.com for details and incentives!.
lnkd.in
This link will take you to a page that’s not on LinkedIn
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Covalent drug design paper. Reactive Site Detection: SILCS-Monte Carlo for accurate cysteine identification. Warhead Optimization: ML models to rank warhead effectiveness. Integrated Workflow: SILCS-Covalent for comprehensive insights.
pubmed.ncbi.nlm.nih.gov
Covalent drug design is an important component in drug discovery. Traditional drugs interact with their target in a reversible equilibrium, while irreversible covalent drugs increase the drug-target...
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SilcsBio 2024.2 Version is officially released. Check out the new features here: .
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Our team is going to be in Montreal for a conference hosted by Chemical Computing Group from June 25th-June 28th. Let us know if you'll be in the area during that time! . #pharameuticalresearch #drugdiscovery.
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#ThrowbackThursday to our study on extending SILCS to RNA targets! 🧬📄 Read more: . #ComputationalChemistry #MolecularModeling #ComputationalDrugDesign #ChemicalInformatics #RNADrugDesign.
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Take a look at an interactive demo of the SILCS technology in use for ligand optimization. See the step by step process in action including the information our FragMaps give you. #pharmaceuticaldrugdesign #CADD #Bioinformatics #ComputationalChemistry.
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