Igor Esarev
@scivel_RED
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Postdoctiral researcher in @iOttGroup. Fighting bugs and cancers with a silver sword. (Un) professional traveler. Иногда пишу дичь.
Joined June 2023
Very happy to present some powerful silver antibiotics working against Gram-negative bugs! Thanks to organizers of @ISBOMC_2025 and my supervisor @iOttGroup!
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It's been more than a month since I successfully defended my thesis, and from early this week I can officially call myself a Doctor! This wouldn't have been possible without the immense support of my supervisor @iOttGroup and the team. Hope to have more updates soon!
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Happy to see group member Igor Esarev @scivel_RED presenting a talk on antibacterial silver #bioorganometallics at the Ferrocene Colloquium 2025 ! https://t.co/JMEO0QostG
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Обыкновенный трампизм
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(8/8) But that’s the end of this project. Hope you enjoy reading my work. Thesis submitted, but more work still awaits. Stay tuned!
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(7/8) Also, I recommend you to read the third part of my project, which was published in collaboration with awesome @Babaklab. This work will tell short but fascinating story about differences between mono- and biscarbenes in their biological effects. https://t.co/bj4sAHEG4U
aces.onlinelibrary.wiley.com
Silver N-heterocyclic carbene complexes in the biscarbene form represent a promising type of TrxR-inhibiting organometallic anticancer drug candidates with activity in vitro and in vivo.
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(6/8) Moreover, we got an upgrade of our lab equipment: a 100x objective lens for the fluorescence microscope. That allowed us to do deeper mechanistic studies using fluorescence and led to understand more about the mode of action of silver complexes in Gram-negative bacteria.
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(5/8) The effect of my complexes turned out to be a direct hit: iodides worked much better against TrxR in E.coli than their chloride analogues.
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(4/8) Gladly, I found a nice method developed in Holmgren group. Check their papers about the effects of Ag+ mixed with antibiotics on different bacteria. https://t.co/HPy9G9J39E
nature.com
Scientific Reports - Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production
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(3/8) Although we saw the effect clearly, we didn’t know why it happened. They seem to have no difference in activity against pure TrxR and GR, the effect of biofilm inhibition was (almost) identical. https://t.co/OWtQ7elEWn
pubs.acs.org
The antibacterial activity of silver species is well-established; however, their mechanism of action has not been adequately explored. Furthermore, issues of low-molecular silver compounds with...
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(2/8) As one of our reviewers noticed, it is necessary to read the first part of the project published in ACS Infectious diseases. Most important: change of halide (chloride to iodide) in silver NHC complex led to stronger antibacterial effect in Gram-(!) pathogenic strains.
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(1/8) Very glad to see this piece of hard work finally published. Since all three parts of my thesis are finally online, I prepared a mini-thread on the project I performed during my time (more than 4 years, wow) in @iOttGroup.
Is silver the new gold? In this paper we report on silver NHC complexes and their antibacterial mechanism of action. https://t.co/o02lpxaIrT
@scivel_RED
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Already excited about presenting my latest work at this conference. Come and see what silver can do to bacteria!
Looking forward to the @MetalBio online symposium next Monday with a talk of group member Igor Esarev @scivel_RED about antibacterial silver #bioorganometallics ! @santigomezruiz
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Your future guardian of America’s health, a short story: The outbreak of measles in Samoa starting in September 2019 created a panic. Schools closed, Christmas events were cancelled, lockdowns ensued. More…
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How to write a scientific article, template 1:
[Auswirkung] aufgrund [Ursache]
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С тем самым днем, когда, спустя целых 3,5 года жизни в Германии, у меня наконец-то спиздили велик. Компенсировано ожидание с лихвой: и тем, что это был ebike, и фактом пиздига прям с парковки института, в котором я работаю.
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Не знаю, для кого это пишу, но: Сегодня попробовал подать на #B1/B2 визу в США для участия в конференции. Ожидаемо, все кончилось запросом админпроверки. Есть среди твиттерожителей подобные случаи? Если что, не надеюсь в быстрый положительный отклик (и от консульства тоже хддд)
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Happy to see our work on antibacterial silver NHC complexes online! In this paper we report on the correlations of solution chemistry with antibacterial activity. Thanks to @BronstrupLab and Hedda Schrey at @MS_fungi for the collaboration! @scivel_RED
pubs.acs.org
The antibacterial activity of silver species is well-established; however, their mechanism of action has not been adequately explored. Furthermore, issues of low-molecular silver compounds with...
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„Graue Eminenz“ im Kanzleramt: der mächtige Mann hinter Scholz, mit zweifelhafter Nähe zum Kreml. 1//16
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